Lysine-Reactive

Lysine / chemistry Agammaglobulinaemia Tyrosine Kinase / metabolism Piperidines / pharmacology Cysteine / chemistry Sulfanilamide Sulfonamides / pharmacology Protein Kinase Inhibitors / pharmacology

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
06 Dec 2023
Historique:
medline: 7 12 2023
pubmed: 21 11 2023
entrez: 21 11 2023
Statut: ppublish

Résumé

The covalent inhibition of a target protein has gained widespread attention in the field of drug discovery. Most of the current covalent drugs utilize the high reactivity of cysteines toward modest electrophiles. However, there is a growing need for warheads that can target lysine residues to expand the range of covalently druggable proteins and to deal with emerging proteins with mutations resistant to cysteine-targeted covalent drugs. We have recently developed an

Identifiants

DOI: 10.1021/jacs.3c08740 PMID: 37987622
pubmed: 37987622
doi: 10.1021/jacs.3c08740
doi:

Substances chimiques

Lysine K3Z4F929H6
Agammaglobulinaemia Tyrosine Kinase EC 2.7.10.2
ibrutinib 1X70OSD4VX
Piperidines 0
Cysteine K848JZ4886
Sulfanilamide 21240MF57M
Sulfonamides 0
Protein Kinase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26202-26212

Auteurs

Masaharu Kawano (M)

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

Syunsuke Murakawa (S)

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

Kenji Higashiguchi (K)

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
ORCID: 0000-0003-4361-4603

Kenji Matsuda (K)

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Fukui Institute for Fundamental Chemistry, Kyoto University, Sakyo-ku, Kyoto 606-8103, Japan.
ORCID: 0000-0002-2420-4214

Tomonori Tamura (T)

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
ORCID: 0000-0003-1648-9296

Itaru Hamachi (I)

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
ERATO (Exploratory Research for Advanced Technology, JST), Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.
ORCID: 0000-0002-3327-3916

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Lysine-Reactive
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Agammaglobulinaemia tyrosine kinase › Lysine-Reactive
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Lysine-Reactive
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Lysine-Reactive
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Sulfamides › Sulfanilamide › Lysine-Reactive
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Lysine-Reactive
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Lysine-Reactive