Communicating computational workflows in a regulatory environment.
BioCompute
HTS
adventitious virus detection
metagenomics
next generation sequencing
vaccine
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
31
12
2022
revised:
14
12
2023
accepted:
10
01
2024
medline:
11
3
2024
pubmed:
15
1
2024
entrez:
14
1
2024
Statut:
ppublish
Résumé
The volume of nucleic acid sequence data has exploded recently, amplifying the challenge of transforming data into meaningful information. Processing data can require an increasingly complex ecosystem of customized tools, which increases difficulty in communicating analyses in an understandable way yet is of sufficient detail to enable informed decisions or repeats. This can be of particular interest to institutions and companies communicating computations in a regulatory environment. BioCompute Objects (BCOs; an instance of pipeline documentation that conforms to the IEEE 2791-2020 standard) were developed as a standardized mechanism for analysis reporting. A suite of BCOs is presented, representing interconnected elements of a computation modeled after those that might be found in a regulatory submission but are shared publicly - in this case a pipeline designed to identify viral contaminants in biological manufacturing, such as for vaccines.
Identifiants
pubmed: 38219969
pii: S1359-6446(24)00009-6
doi: 10.1016/j.drudis.2024.103884
pii:
doi:
Substances chimiques
Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103884Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.