Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins.
B complex
Cryo-EM
Higher Order Spliceosomal Complexes
Spliceosome
pre-mRNA Splicing
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
27
09
2023
accepted:
26
01
2024
revised:
25
01
2024
medline:
18
3
2024
pubmed:
22
2
2024
entrez:
22
2
2024
Statut:
ppublish
Résumé
The B complex is a key intermediate stage of spliceosome assembly. To improve the structural resolution of monomeric, human spliceosomal B (hB) complexes and thereby generate a more comprehensive hB molecular model, we determined the cryo-EM structure of B complex dimers formed in the presence of ATP
Identifiants
pubmed: 38383864
doi: 10.1038/s44318-024-00052-1
pii: 10.1038/s44318-024-00052-1
pmc: PMC10943123
doi:
Substances chimiques
RNA Splice Sites
0
RNA Precursors
0
TCERG1 protein, human
0
Transcriptional Elongation Factors
0
BUD31 protein, human
0
Nuclear Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1065-1088Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : SFB860
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : SFB1565
Informations de copyright
© 2024. The Author(s).
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