Zinc

Zinc / chemistry Peptide Nucleic Acids / chemistry Chelating Agents / chemistry RNA / chemistry Catalysis Amines / chemistry Kinetics Organophosphates
PNAzyme RNA bulge RNA substrate metal chelate phosphodiester cleavage

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
03 May 2024
Historique:
received: 01 03 2024
revised: 20 04 2024
accepted: 24 04 2024
medline: 11 5 2024
pubmed: 11 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

PNAzymes are a group of artificial enzymes which show promising results in selective and efficient cleavage of RNA targets. In the present study, we introduce a series of metal chelating groups based on

Identifiants

DOI: 10.3390/molecules29092123 PMID: 38731616
pubmed: 38731616
pii: molecules29092123
doi: 10.3390/molecules29092123
pii:
doi:

Substances chimiques

Zinc J41CSQ7QDS
Peptide Nucleic Acids 0
Chelating Agents 0
RNA 63231-63-0
2-(hydroxypropyl)-4-nitrophenyl phosphate 0
Amines 0
Organophosphates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Marie Curie
ID : 721613
Pays : United Kingdom

Auteurs

Søren W Svenningsen (SW)

Department of Chemistry, University of Sheffield, Richard Roberts Building, Sheffield S3 7HF, UK.

Olivia Luige (O)

Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Halsovagen 9, 14157 Huddinge, Sweden.
ORCID: 0000-0002-1448-5630

Zeyed Abdulkarim (Z)

Department of Chemistry, University of Sheffield, Richard Roberts Building, Sheffield S3 7HF, UK.
ORCID: 0000-0003-3868-8253

Roger Strömberg (R)

Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Halsovagen 9, 14157 Huddinge, Sweden.
Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Nobels alle 8 B, 14152 Huddinge, Sweden.
ORCID: 0000-0002-7902-2688

Nicholas H Williams (NH)

Department of Chemistry, University of Sheffield, Richard Roberts Building, Sheffield S3 7HF, UK.
ORCID: 0000-0002-4457-4220

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › Zinc
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Acides nucléiques peptidiques › Zinc
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents séquestrants › Chélateurs › Zinc
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Zinc
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Zinc
questionsmedicales.fr › Composés chimiques organiques › Amines › Zinc
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Zinc
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Organophosphates › Zinc