Kinetoplastid kinetochore proteins KKT14-KKT15 are divergent Bub1/BubR1-Bub3 proteins.

Kinetochores / metabolism Protozoan Proteins / metabolism Trypanosoma brucei brucei / metabolism Protein Serine-Threonine Kinases / metabolism Models, Molecular Amino Acid Sequence Phylogeny Protein Binding Crystallography, X-Ray Chromosome Segregation Cell Cycle Proteins / metabolism
Trypanosoma brucei chromosome segregation kinetochore kinetoplastid spindle checkpoint

Journal

Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419

Informations de publication

Date de publication:
Jun 2024
Historique:
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 11 6 2024
Statut: ppublish

Résumé

Faithful transmission of genetic material is crucial for the survival of all organisms. In many eukaryotes, a feedback control mechanism called the spindle checkpoint ensures chromosome segregation fidelity by delaying cell cycle progression until all chromosomes achieve proper attachment to the mitotic spindle. Kinetochores are the macromolecular complexes that act as the interface between chromosomes and spindle microtubules. While most eukaryotes have canonical kinetochore proteins that are widely conserved, kinetoplastids such as

Identifiants

DOI: 10.1098/rsob.240025 PMID: 38862021
pubmed: 38862021
doi: 10.1098/rsob.240025
doi:

Substances chimiques

Protozoan Proteins 0
Protein Serine-Threonine Kinases EC 2.7.11.1
Cell Cycle Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

240025

Subventions

Organisme : Wellcome / EPSRC Centre for Interventional and Surgical Sciences
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Auteurs

Daniel Ballmer (D)

Department of Biochemistry, University of Oxford , Oxford OX1 3QU, UK.
The Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh , Edinburgh EH9 3BF, UK.
ORCID: 0000-0002-1966-0960

William Carter (W)

Department of Biochemistry, University of Oxford , Oxford OX1 3QU, UK.

Jolien J E van Hooff (JJE)

Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University and Research , 6708 HB Wageningen, The Netherlands.
ORCID: 0000-0001-8754-1894

Eelco C Tromer (EC)

Cell Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Faculty of Science and Engineering, University of Groningen , 9747 AG Groningen, The Netherlands.
ORCID: 0000-0003-3540-7727

Midori Ishii (M)

Department of Biochemistry, University of Oxford , Oxford OX1 3QU, UK.
The Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh , Edinburgh EH9 3BF, UK.

Patryk Ludzia (P)

Department of Biochemistry, University of Oxford , Oxford OX1 3QU, UK.

Bungo Akiyoshi (B)

Department of Biochemistry, University of Oxford , Oxford OX1 3QU, UK.
The Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh , Edinburgh EH9 3BF, UK.
ORCID: 0000-0001-6010-394X

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Centromère › Kinétochores › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Ségrégation des chromosomes › Kinetoplastid kinetochore proteins KKT14-KKT15...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Kinetoplastid kinetochore proteins KKT14-KKT15...