Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 Oct 2024
08 Oct 2024
Historique:
received:
20
07
2023
accepted:
12
09
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
8
10
2024
Statut:
epublish
Résumé
Hybridization and polyploidy are powerful evolutionary forces, inducing a range of phenotypic outcomes, including non-additive expression, subgenome dominance, deviations in genomic dosage, and transcriptome downsizing. The reasons for these patterns and whether they are universal adaptive responses to genome merging and doubling remain debated. To address this, we develop a thermodynamic model of gene expression based on transcription factor (TF)-promoter binding. Applied to hybridization between species with divergent gene expression levels, cell volumes, or euchromatic ratios, this model distinguishes the effects of hybridization from those of polyploidy. Our results align with empirical observations, suggesting that gene regulation patterns in hybrids and polyploids often stem from the constrained interplay between inherited diverged regulatory networks rather than from subsequent adaptive evolution. In addition, occurrence of certain phenotypic traits depend on specific assumptions about promoter-TF coevolution and their distribution within the hybrid's nucleoplasm, offering new research avenues to understand the underlying mechanisms. In summary, our model explains how the legacy of divergent species directly influences the phenotypic traits of hybrids and allopolyploids.
Identifiants
pubmed: 39379366
doi: 10.1038/s41467-024-52546-5
pii: 10.1038/s41467-024-52546-5
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8714Subventions
Organisme : Grantová Agentura České Republiky (Grant Agency of the Czech Republic)
ID : 21-25185S
Organisme : Grantová Agentura České Republiky (Grant Agency of the Czech Republic)
ID : 21-25185S
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy (Ministry of Education, Youth and Sports)
ID : e-INFRA 90254
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy (Ministry of Education, Youth and Sports)
ID : CZ.02.1.01/0.0/0.0/16_025/0007370
Informations de copyright
© 2024. The Author(s).
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