Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Humans
Stevens-Johnson Syndrome
/ immunology
Single-Cell Analysis
/ methods
Keratinocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Receptors, Antigen, T-Cell
/ immunology
Skin
/ immunology
T-Lymphocytes, Cytotoxic
/ immunology
Granzymes
/ metabolism
Transcriptome
Male
Perforin
/ metabolism
Female
Histocompatibility Antigens Class I
/ genetics
Antigens, Differentiation, T-Lymphocyte
/ genetics
Macrophages
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 Oct 2024
08 Oct 2024
Historique:
received:
12
12
2023
accepted:
27
09
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
8
10
2024
Statut:
epublish
Résumé
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening cutaneous drug reaction mediated by human leukocyte antigen (HLA) class I-restricted CD8
Identifiants
pubmed: 39379371
doi: 10.1038/s41467-024-52990-3
pii: 10.1038/s41467-024-52990-3
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Granzymes
EC 3.4.21.-
GNLY protein, human
0
Perforin
126465-35-8
Histocompatibility Antigens Class I
0
Antigens, Differentiation, T-Lymphocyte
0
GZMB protein, human
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8722Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : U01AI154659
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : P50GM115305
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01HG010863
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R21AI139021
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01AI152183
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 2 D43 TW010559
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 2 D43 TW010559
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : K43 TW011178-01
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01AI152183
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 2 D43 TW010559
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : P50GM115305
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT1123499
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT2028952
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT2028952
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT2028952
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT2028952
Investigateurs
Jason Trubiano
(J)
Informations de copyright
© 2024. The Author(s).
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