The association of pre-operative biomarkers of endothelial dysfunction with the risk of post-operative neurocognitive disorders: results from the BioCog study.
Humans
Male
Female
Biomarkers
/ blood
Aged
Postoperative Complications
/ blood
Vascular Cell Adhesion Molecule-1
/ blood
Endothelium, Vascular
/ physiopathology
Arginine
/ analogs & derivatives
Prospective Studies
Follow-Up Studies
Aged, 80 and over
Postoperative Cognitive Complications
/ blood
Risk Factors
Neuropsychological Tests
Elective Surgical Procedures
/ adverse effects
Delirium
/ blood
von Willebrand Factor
/ metabolism
Intercellular Adhesion Molecule-1
/ blood
Ageing
Biomarkers
Cognitive dysfunction
Endothelial dysfunction
Endothelial function
Neuropsychological tests
Postoperative cognitive complications
Postoperative cognitive dysfunction
Postoperative delirium
Surgery
Journal
BMC anesthesiology
ISSN: 1471-2253
Titre abrégé: BMC Anesthesiol
Pays: England
ID NLM: 100968535
Informations de publication
Date de publication:
08 Oct 2024
08 Oct 2024
Historique:
received:
22
04
2024
accepted:
09
09
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
8
10
2024
Statut:
epublish
Résumé
Endothelial dysfunction (ED) promotes the development of atherosclerosis, and studies suggest an association with age-related neurocognitive disorders. It is currently unclear whether ED is also associated with the risk of perioperative neurocognitive disorders. We included 788 participants aged ≥ 65 years of the BioCog study. Patients were scheduled to undergo elective surgery with expected duration > 60 min. Blood was collected before surgery for measurement of 5 biomarkers of ED: asymmetric and symmetric dimethylarginine (ADMA; SDMA), intercellular and vascular adhesion molecule (ICAM-1, VCAM-1), and von Willebrand factor (vWF). Patients were monitored for the occurrence of postoperative delirium (POD) daily until the 7th postoperative day. 537 (68.1%) patients returned for a 3-month follow-up. Post-operative cognitive dysfunction (POCD) was defined from the change in results on a battery of 6 neuropsychological tests between baseline and 3 months, compared to the change in results of a control group during the 3-month interval. The associations of each of the 5 ED biomarkers with POD and POCD respectively were determined using multiple logistic regression analyses with adjustment for age, sex, surgery type, pre-morbid IQ, body mass index, hypertension, diabetes, HbA1C, triglyceride, total and HDL cholesterol. 19.8% of 788 patients developed POD; 10.1% of 537 patients had POCD at 3 months. Concentrations of ED biomarkers were not significantly associated with a POD. A higher VCAM-1 concentration was associated with a reduced POCD risk (adjusted odds ratio 0.55; 95% CI: 0.35-0.86). No further statistically significant results were found. Pre-operative concentrations of ED biomarkers were not associated with POD risk. We unexpectedly found higher VCAM-1 to be associated with a reduced POCD risk. Further studies are needed to evaluate these findings.
Identifiants
pubmed: 39379830
doi: 10.1186/s12871-024-02722-3
pii: 10.1186/s12871-024-02722-3
doi:
Substances chimiques
Biomarkers
0
Vascular Cell Adhesion Molecule-1
0
Arginine
94ZLA3W45F
von Willebrand Factor
0
N,N-dimethylarginine
63CV1GEK3Y
Intercellular Adhesion Molecule-1
126547-89-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
358Informations de copyright
© 2024. The Author(s).
Références
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