Eric S Goetzman

Affiliations

Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.. Electronic address: eric.goetzman@chp.edu.

Publications (26)

GM3 synthase deficiency increases brain glucose metabolism in mice.

Molecular genetics and metabolism

Avec: Sivakama S Bharathi , Bob B Zhang , Eli Paul , Yuxun Zhang , Alexandra V Schmidt , Benjamin Fowler , Yijen Wu , Michael Tiemeyer , Kei-Ichiro Inamori , Jin-Ichi Inokuchi , Eric S Goetzman

Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.

Journal of the American Society of Nephrology : JASN

Avec: Kasey Cargill , Shelby L Hemker , Andrew Clugston , Anjana Murali , Elina Mukherjee , Jiao Liu , Daniel Bushnell , Andrew J Bodnar , Zubaida Saifudeen , Jacqueline Ho , Carlton M Bates , Dennis Kostka , Eric S Goetzman , Sunder Sims-Lucas

The common K333Q polymorphism in long-chain acyl-CoA dehydrogenase (LCAD) reduces enzyme stability and function.

Molecular genetics and metabolism

Avec: Megan E Beck , Yuxun Zhang , Sivakama S Bharathi , Beata Kosmider , Karim Bahmed , Mary K Dahmer , Lawrence M Nogee , Eric S Goetzman

The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide.

Redox biology

Avec: Yuxun Zhang , Sivakama S Bharathi , Megan E Beck , Eric S Goetzman

Lysine acylation causes collateral damage in inborn errors of metabolism.

Science translational medicine

Avec: Eric S Goetzman , Jerry Vockley

Substantial Downregulation of Mitochondrial and Peroxisomal Proteins during Acute Kidney Injury revealed by Data-Independent Acquisition Proteomics.

bioRxiv : the preprint server for biology

Avec: Jordan B Burton , Anne Silva-Barbosa , Joanna Bons , Jacob Rose , Katherine Pfister , Fabia Simona , Tejas Gandhi , Lukas Reiter , Oliver Bernhardt , Christie L Hunter , Eric S Goetzman , Sunder Sims-Lucas , Birgit Schilling

A Novel Transgenic Mouse Model Implicates

International journal of molecular sciences

Avec: Alexandra V Schmidt , Satdarshan P Monga , Edward V Prochownik , Eric S Goetzman

Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance.

Diabetologia

Avec: Zhenwei Gong , Xinyi Zhang , Kai Su , Ruihua Jiang , Zhe Sun , Wei Chen , Erick Forno , Eric S Goetzman , Jieru Wang , H Henry Dong , Partha Dutta , Radhika Muzumdar

Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency.

Journal of lipid research

Avec: Andrea S Pereyra , Kate L Harris , Arvin H Soepriatna , Quin A Waterbury , Sivakama S Bharathi , Yuxun Zhang , Kelsey H Fisher-Wellman , Craig J Goergen , Eric S Goetzman , Jessica M Ellis

Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial function.

bioRxiv : the preprint server for biology

Avec: Shubhnita Singh , Ariane Bruder-Nascimento , Rafael M Costa , Juliano V Alves , Sivakama Bharathi , Eric S Goetzman , Thiago Bruder-Nascimento

Dicarboxylic Acid Dietary Supplementation Protects Against Acute Kidney Injury.

Journal of the American Society of Nephrology : JASN

Avec: Anne C S Barbosa , Katherine E Pfister , Takuto Chiba , Joanna Bons , Jacob P Rose , Jordan B Burton , Christina D King , Amy O'Broin , Victoria Young , Bob Zhang , Bharathi Sivakama , Alexandra V Schmidt , Rebecca Uhlean , Akira Oda , Birgit Schilling , Eric S Goetzman , Sunder Sims-Lucas

Dietary dicarboxylic acids provide a non-storable alternative fat source that protects mice against obesity.

The Journal of clinical investigation

Avec: Eric S Goetzman , Bob B Zhang , Yuxun Zhang , Sivakama S Bharathi , Joanna Bons , Jacob Rose , Samah Shah , Keaton J Solo , Alexandra V Schmidt , Adam C Richert , Steven J Mullett , Stacy L Gelhaus , Krithika S Rao , Sruti S Shiva , Katherine E Pfister , Anne Silva Barbosa , Sunder Sims-Lucas , Steven F Dobrowolski , Birgit Schilling

Cystic fibrosis-related metabolic defects: crosstalk between ion channels and organs.

The Journal of clinical investigation

Avec: Sunder Sims-Lucas , Eric S Goetzman , Thomas R Kleyman

Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner.

Biomolecules

Avec: Alexandra V Schmidt , Sivakama S Bharathi , Keaton J Solo , Joanna Bons , Jacob P Rose , Birgit Schilling , Eric S Goetzman

Loss of long-chain acyl-CoA dehydrogenase protects against acute kidney injury.

bioRxiv : the preprint server for biology

Avec: Takuto Chiba , Akira Oda , Yuxun Zhang , Joanna Bons , Sivakama S Bharathi , Katherine E Pfister , Bob B Zhang , Adam C Richert , Birgit Schilling , Eric S Goetzman , Sunder Sims-Lucas

Acquired deficiency of peroxisomal dicarboxylic acid catabolism is a metabolic vulnerability in hepatoblastoma.

The Journal of biological chemistry

Avec: Huabo Wang , Jie Lu , Xiaoguang Chen , Marie Schwalbe , Joanna E Gorka , Jordan A Mandel , Jinglin Wang , Eric S Goetzman , Sarangarajan Ranganathan , Steven F Dobrowolski , Edward V Prochownik

Mesenchymal stem cell energy deficit and oxidative stress contribute to osteopenia in the Pah

Molecular genetics and metabolism

Avec: Steven F Dobrowolski , Cayla Sudano , Yu Leng Phua , Irina L Tourkova , Kayla Spridik , Eric S Goetzman , Jerry Vockley , Harry C Blair

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD.

Nature communications

Avec: Sayan Ghosh , Ruchi Sharma , Sridhar Bammidi , Victoria Koontz , Mihir Nemani , Meysam Yazdankhah , Katarzyna M Kedziora , Donna Beer Stolz , Callen T Wallace , Cheng Yu-Wei , Jonathan Franks , Devika Bose , Peng Shang , Helena M Ambrosino , James R Dutton , Zhaohui Geng , Jair Montford , Jiwon Ryu , Dhivyaa Rajasundaram , Stacey Hose , José-Alain Sahel , Rosa Puertollano , Toren Finkel , J Samuel Zigler , Yuri Sergeev , Simon C Watkins , Eric S Goetzman , Deborah A Ferrington , Miguel Flores-Bellver , Kai Kaarniranta , Akrit Sodhi , Kapil Bharti , James T Handa , Debasish Sinha

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD.

bioRxiv : the preprint server for biology

Avec: Sayan Ghosh , Ruchi Sharma , Sridhar Bammidi , Victoria Koontz , Mihir Nemani , Meysam Yazdankhah , Katarzyna M Kedziora , Callen T Wallace , Cheng Yu-Wei , Jonathan Franks , Devika Bose , Dhivyaa Rajasundaram , Stacey Hose , José-Alain Sahel , Rosa Puertollano , Toren Finkel , J Samuel Zigler , Yuri Sergeev , Simon C Watkins , Eric S Goetzman , Miguel Flores-Bellver , Kai Kaarniranta , Akrit Sodhi , Kapil Bharti , James T Handa , Debasish Sinha

Substantial downregulation of mitochondrial and peroxisomal proteins during acute kidney injury revealed by data-independent acquisition proteomics.

Proteomics

Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.

JACC. Basic to translational science

Avec: Thomas E Sharp , Zhenwei Gong , Amy Scarborough , Eric S Goetzman , Murtuza J Ali , Pablo Spaletra , David J Lefer , Radhika H Muzumdar , Traci T Goodchild

Role of mitochondrial acyl-CoA dehydrogenases in the metabolism of dicarboxylic fatty acids.

Biochemical and biophysical research communications

Avec: Sivakama S Bharathi , Yuxun Zhang , Zhenwei Gong , Radhika Muzumdar , Eric S Goetzman

Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.

The Journal of biological chemistry

Avec: Huabo Wang , Jie Lu , Sucheta Kulkarni , Weiqi Zhang , Joanna E Gorka , Jordan A Mandel , Eric S Goetzman , Edward V Prochownik

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.

Journal of the American Society of Nephrology : JASN

Avec: Takuto Chiba , Kevin D Peasley , Kasey R Cargill , Katherine V Maringer , Sivakama S Bharathi , Elina Mukherjee , Yuxun Zhang , Anja Holtz , Nathan Basisty , Shiva D Yagobian , Birgit Schilling , Eric S Goetzman , Sunder Sims-Lucas

An acyl-CoA dehydrogenase microplate activity assay using recombinant porcine electron transfer flavoprotein.

Analytical biochemistry

Avec: Yuxun Zhang , Al-Walid Mohsen , Catherine Kochersperger , Keaton Solo , Alexandra V Schmidt , Jerry Vockley , Eric S Goetzman

Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.

Scientific reports

Avec: Eric S Goetzman , Sivakama S Bharathi , Yuxun Zhang , Xue-Jun Zhao , Steven F Dobrowolski , Kevin Peasley , Sunder Sims-Lucas , Satdarshan P Monga

Réseau de co-auteurs

Sivakama S Bharathi 10 collaborations

Yuxun Zhang 10 collaborations

Sunder Sims-Lucas 9 collaborations

Birgit Schilling 7 collaborations

Alexandra V Schmidt 6 collaborations

Joanna Bons 6 collaborations

Steven F Dobrowolski 4 collaborations

Bob B Zhang 3 collaborations

Jerry Vockley 3 collaborations

Jordan B Burton 3 collaborations

Jacob Rose 3 collaborations

Edward V Prochownik 3 collaborations

Zhenwei Gong 3 collaborations

Katherine E Pfister 3 collaborations

Takuto Chiba 3 collaborations

Elina Mukherjee 2 collaborations

Megan E Beck 2 collaborations

Anne Silva-Barbosa 2 collaborations

Katherine Pfister 2 collaborations

Fabia Simona 2 collaborations

Tejas Gandhi 2 collaborations

Lukas Reiter 2 collaborations

Oliver Bernhardt 2 collaborations

Christie L Hunter 2 collaborations

Satdarshan P Monga 2 collaborations

Radhika Muzumdar 2 collaborations

Jacob P Rose 2 collaborations

Akira Oda 2 collaborations

Keaton J Solo 2 collaborations

Adam C Richert 2 collaborations

Huabo Wang 2 collaborations

Jie Lu 2 collaborations

Joanna E Gorka 2 collaborations

Jordan A Mandel 2 collaborations

Sayan Ghosh 2 collaborations

Ruchi Sharma 2 collaborations

Sridhar Bammidi 2 collaborations

Victoria Koontz 2 collaborations

Mihir Nemani 2 collaborations

Meysam Yazdankhah 2 collaborations

Katarzyna M Kedziora 2 collaborations

Callen T Wallace 2 collaborations

Cheng Yu-Wei 2 collaborations

Jonathan Franks 2 collaborations

Devika Bose 2 collaborations

Dhivyaa Rajasundaram 2 collaborations

Stacey Hose 2 collaborations

José-Alain Sahel 2 collaborations

Rosa Puertollano 2 collaborations

Toren Finkel 2 collaborations

J Samuel Zigler 2 collaborations

Yuri Sergeev 2 collaborations

Simon C Watkins 2 collaborations

Miguel Flores-Bellver 2 collaborations

Kai Kaarniranta 2 collaborations

Akrit Sodhi 2 collaborations

Kapil Bharti 2 collaborations

James T Handa 2 collaborations

Debasish Sinha 2 collaborations

Eli Paul 1 collaboration

Benjamin Fowler 1 collaboration

Yijen Wu 1 collaboration

Michael Tiemeyer 1 collaboration

Kei-Ichiro Inamori 1 collaboration

Jin-Ichi Inokuchi 1 collaboration

Kasey Cargill 1 collaboration

Shelby L Hemker 1 collaboration

Andrew Clugston 1 collaboration

Anjana Murali 1 collaboration

Jiao Liu 1 collaboration

Daniel Bushnell 1 collaboration

Andrew J Bodnar 1 collaboration

Zubaida Saifudeen 1 collaboration

Jacqueline Ho 1 collaboration

Carlton M Bates 1 collaboration

Dennis Kostka 1 collaboration

Beata Kosmider 1 collaboration

Karim Bahmed 1 collaboration

Mary K Dahmer 1 collaboration

Lawrence M Nogee 1 collaboration

Xinyi Zhang 1 collaboration

Kai Su 1 collaboration

Ruihua Jiang 1 collaboration

Zhe Sun 1 collaboration

Wei Chen 1 collaboration

Erick Forno 1 collaboration

Jieru Wang 1 collaboration

H Henry Dong 1 collaboration

Partha Dutta 1 collaboration

Andrea S Pereyra 1 collaboration

Kate L Harris 1 collaboration

Arvin H Soepriatna 1 collaboration

Quin A Waterbury 1 collaboration

Kelsey H Fisher-Wellman 1 collaboration

Craig J Goergen 1 collaboration

Jessica M Ellis 1 collaboration

Shubhnita Singh 1 collaboration

Ariane Bruder-Nascimento 1 collaboration

Rafael M Costa 1 collaboration

Juliano V Alves 1 collaboration

Sivakama Bharathi 1 collaboration

Thiago Bruder-Nascimento 1 collaboration

Anne C S Barbosa 1 collaboration

Christina D King 1 collaboration

Amy O'Broin 1 collaboration

Victoria Young 1 collaboration

Bob Zhang 1 collaboration

Bharathi Sivakama 1 collaboration

Rebecca Uhlean 1 collaboration

Samah Shah 1 collaboration

Steven J Mullett 1 collaboration

Stacy L Gelhaus 1 collaboration

Krithika S Rao 1 collaboration

Sruti S Shiva 1 collaboration

Anne Silva Barbosa 1 collaboration

Thomas R Kleyman 1 collaboration

Xiaoguang Chen 1 collaboration

Marie Schwalbe 1 collaboration

Jinglin Wang 1 collaboration

Sarangarajan Ranganathan 1 collaboration

Cayla Sudano 1 collaboration

Yu Leng Phua 1 collaboration

Irina L Tourkova 1 collaboration

Kayla Spridik 1 collaboration

Harry C Blair 1 collaboration

Donna Beer Stolz 1 collaboration

Peng Shang 1 collaboration

Helena M Ambrosino 1 collaboration

James R Dutton 1 collaboration

Zhaohui Geng 1 collaboration

Jair Montford 1 collaboration

Jiwon Ryu 1 collaboration

Deborah A Ferrington 1 collaboration

Thomas E Sharp 1 collaboration

Amy Scarborough 1 collaboration

Murtuza J Ali 1 collaboration

Pablo Spaletra 1 collaboration

David J Lefer 1 collaboration

Radhika H Muzumdar 1 collaboration

Traci T Goodchild 1 collaboration

Sucheta Kulkarni 1 collaboration

Weiqi Zhang 1 collaboration

Kevin D Peasley 1 collaboration

Kasey R Cargill 1 collaboration

Katherine V Maringer 1 collaboration

Anja Holtz 1 collaboration

Nathan Basisty 1 collaboration

Shiva D Yagobian 1 collaboration

Al-Walid Mohsen 1 collaboration

Catherine Kochersperger 1 collaboration

Keaton Solo 1 collaboration

Xue-Jun Zhao 1 collaboration

Kevin Peasley 1 collaboration