Sebastien Lacroix-Desmazes

Affiliations

Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.

Publications (33)

Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII-encoding mRNA.

Haematologica

Avec: Jules Russick , Sandrine Delignat , Peter Milanov , Olivier Christophe , Gábor Boros , Cécile V Denis , Peter J Lenting , Srinivas V Kaveri , Sébastien Lacroix-Desmazes

Prevention of the anti-factor VIII memory B-cell response by inhibition of Bruton tyrosine kinase in experimental hemophilia A.

Haematologica

Avec: Sandrine Delignat , Jules Russick , Bagirath Gangadharan , Julie Rayes , Mathieu Ing , Jan Voorberg , Srinivas V Kaveri , Sébastien Lacroix-Desmazes

IVIg increases interleukin-11 levels, which in turn contribute to increased platelets, VWF and FVIII in mice and humans.

Clinical and experimental immunology

Avec: A Nguyen , Y Repesse , M Ebbo , Y Allenbach , O Benveniste , J M Vallat , L Magy , S Deshayes , G Maigné , H de Boysson , A Karnam , S Delignat , S Lacroix-Desmazes , J Bayry , A Aouba

Japanese Encephalitis Virus Infected Human Monocyte-Derived Dendritic Cells Activate a Transcriptional Network Leading to an Antiviral Inflammatory Response.

Frontiers in immunology

Avec: Shailendra Chauhan , Deepak Kumar Rathore , Shilpa Sachan , Sebastien Lacroix-Desmazes , Nimesh Gupta , Amit Awasthi , Sudhanshu Vrati , Manjula Kalia

Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme.

Communications biology

Avec: Cyril Planchais , Remi Noe , Marie Gilbert , Maxime Lecerf , Srini V Kaveri , Sébastien Lacroix-Desmazes , Lubka T Roumenina , Jordan D Dimitrov

Inhibitors-Recent insights.

Haemophilia : the official journal of the World Federation of Hemophilia

Avec: Kathleen P Pratt , Valder R Arruda , Sébastien Lacroix-Desmazes

Emergence of antibodies endowed with proteolytic activity against High-mobility group box 1 protein (HMGB1) in patients surviving septic shock.

Cellular immunology

Avec: Stéphanie Barnay-Verdier , Chloé Borde , Lakhdar Fattoum , Bharath Wootla , Sébastien Lacroix-Desmazes , Srini Kaveri , Sébastien Gibot , Vincent Maréchal

Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia A.

PloS one

Avec: Delphine Bachelet , Thilo Albert , Cyprien Mbogning , Signe Hässler , Yuan Zhang , Stephan Schultze-Strasser , Yohann Repessé , Julie Rayes , Anna Pavlova , Behnaz Pezeshkpoor , Kerstin Liphardt , Julie E Davidson , Agnès Hincelin-Méry , Pierre Dönnes , Sébastien Lacroix-Desmazes , Christoph Königs , Johannes Oldenburg , Philippe Broët , Auteur inconnu

Efanesoctocog alfa: the renaissance of Factor VIII replacement therapy.

Haematologica

Avec: Yesim Dargaud , Alexandre Leuci , Alejandra Reyes Ruiz , Sebastien Lacroix-Desmazes

Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies.

Molecular immunology

Avec: Maxime Lecerf , Alexia Kanyavuz , Sébastien Lacroix-Desmazes , Jordan D Dimitrov

The nitrone spin trap 5,5‑dimethyl‑1‑pyrroline N‑oxide binds to toll-like receptor-2-TIR-BB-loop domain and dampens downstream inflammatory signaling.

Biochimica et biophysica acta. Molecular basis of disease

Avec: Marcos D Muñoz , Lucas J Gutierrez , Sandrine Delignat , Jules Russick , Sandra E Gomez Mejiba , Sebastien Lacroix-Desmazes , Ricardo D Enriz , Dario C Ramirez

Tolerating Factor VIII: Recent Progress.

Frontiers in immunology

Avec: Sebastien Lacroix-Desmazes , Jan Voorberg , David Lillicrap , David W Scott , Kathleen P Pratt

Noncanonical Functions of Antibodies.

Trends in immunology

Avec: Jordan D Dimitrov , Sébastien Lacroix-Desmazes

Removal of Mannose-Ending Glycan at Asn

Frontiers in immunology

Avec: Sandrine Delignat , Julie Rayes , Suryasarathi Dasgupta , Bagirath Gangadharan , Cécile V Denis , Olivier D Christophe , Jagadeesh Bayry , Srinivas V Kaveri , Sébastien Lacroix-Desmazes

Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies.

International journal of molecular sciences

Avec: Marie Wiatr , Maya Hadzhieva , Maxime Lecerf , Rémi Noé , Sune Justesen , Sébastien Lacroix-Desmazes , Marie-Agnès Dragon-Durey , Jordan D Dimitrov

Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme.

Molecular immunology

Avec: Marie Wiatr , Nicolas S Merle , Idris Boudhabhay , Victoria Poillerat , Sofia Rossini , Maxime Lecerf , Srini V Kaveri , Sébastian Lacroix-Desmazes , Lubka T Roumenina , Jordan D Dimitrov

Breaking the law: unconventional strategies for antibody diversification.

Nature reviews. Immunology

Avec: Alexia Kanyavuz , Annaelle Marey-Jarossay , Sébastien Lacroix-Desmazes , Jordan D Dimitrov

Natural Antibodies: from First-Line Defense Against Pathogens to Perpetual Immune Homeostasis.

Clinical reviews in allergy & immunology

Avec: Mohan S Maddur , Sébastien Lacroix-Desmazes , Jordan D Dimitrov , Michel D Kazatchkine , Jagadeesh Bayry , Srini V Kaveri

Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance.

Frontiers in immunology

Avec: Angelina Mimoun , Sandrine Delignat , Ivan Peyron , Victoria Daventure , Maxime Lecerf , Jordan D Dimitrov , Srinivas V Kaveri , Jagadeesh Bayry , Sébastien Lacroix-Desmazes

The IgG-degrading enzyme, Imlifidase, restores the therapeutic activity of FVIII in inhibitor-positive hemophilia A mice.

Haematologica

Avec: Melissa Bou-Jaoudeh , Sandrine Delignat , Victoria Daventure , Jan Astermark , Hervé Lévesque , Jordan D Dimitrov , Claire Deligne , Valérie Proulle , Sébastien Lacroix-Desmazes

Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy.

Journal of thrombosis and haemostasis : JTH

Avec: Angelina Mimoun , Melissa Bou-Jaoudeh , Sandrine Delignat , Victoria Daventure , Alejandra Reyes Ruiz , Maxime Lecerf , Aurélien Azam , Remi Noe , Ivan Peyron , Olivier D Christophe , Peter J Lenting , Valérie Proulle , Jenny McIntosh , Amit C Nathwani , Jordan D Dimitrov , Cécile V Denis , Sébastien Lacroix-Desmazes

Imlifidase, a new option to optimize the management of patients with hemophilia A on emicizumab.

Journal of thrombosis and haemostasis : JTH

Avec: Melissa Bou-Jaoudeh , Angelina Mimoun , Sandrine Delignat , Ivan Peyron , Ladislas Capdevila , Victoria Daventure , Claire Deligne , Jordan D Dimitrov , Olivier D Christophe , Cécile V Denis , Peter J Lenting , Valérie Proulle , Sébastien Lacroix-Desmazes

[Origin and nature of the neutralizing immune response against therapeutic factor VIII].

Medecine sciences : M/S

Avec: Mélissa Bou Jaoudeh , Sandrine Delignat , Aditi Varthaman , Sébastien Lacroix-Desmazes

IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies.

Nature medicine

Avec: Christian Leborgne , Elena Barbon , Jeffrey M Alexander , Hayley Hanby , Sandrine Delignat , Daniel M Cohen , Fanny Collaud , Saghana Muraleetharan , Dan Lupo , Joseph Silverberg , Karen Huang , Laetitia van Wittengerghe , Béatrice Marolleau , Adeline Miranda , Anna Fabiano , Victoria Daventure , Heena Beck , Xavier M Anguela , Giuseppe Ronzitti , Sean M Armour , Sebastien Lacroix-Desmazes , Federico Mingozzi

Stimulation with FITC-labeled antigens confers B cells with regulatory properties.

Cellular immunology

Avec: Cyril Planchais , Julie Rayes , Sandrine Delignat , Shina Pashova , Aditi Varthaman , Anastas Pashov , Jagadeesh Bayry , Srinivas V Kaveri , Jordan D Dimitrov , Sebastien Lacroix-Desmazes

Emerging benefits of Fc fusion technology in the context of recombinant factor VIII replacement therapy.

Haemophilia : the official journal of the World Federation of Hemophilia

Avec: Shannon L Meeks , Sébastien Lacroix-Desmazes

Therapeutic normal IgG intravenous immunoglobulin activates Wnt-β-catenin pathway in dendritic cells.

Communications biology

Avec: Anupama Karnam , Naresh Rambabu , Mrinmoy Das , Melissa Bou-Jaoudeh , Sandrine Delignat , Fabian Käsermann , Sébastien Lacroix-Desmazes , Srini V Kaveri , Jagadeesh Bayry

Use of cysteine as a spectroscopic probe for determination of heme-scavenging capacity of serum proteins and whole human serum.

Journal of pharmaceutical and biomedical analysis

Avec: Rémi Noé , Nina Bozinovic , Maxime Lecerf , Sébastien Lacroix-Desmazes , Jordan D Dimitrov

Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?

Haematologica

Avec: Aditi Varthaman , Sébastien Lacroix-Desmazes

Acquired Hemophilia A in IgG4-Related Disease: Case Report, Immunopathogenic Study, and Review of the Literature.

Frontiers in immunology

Avec: Sébastien Sanges , Emmanuelle Jeanpierre , Benjamin Lopez , Jules Russick , Sandrine Delignat , Benjamin Carpentier , Romain Dubois , Sylvain Dubucquoi , Thomas Guerrier , Éric Hachulla , Pierre-Yves Hatron , Camille Paris , Sophie Susen , David Launay , Sébastien Lacroix-Desmazes , Louis Terriou

High FVIII concentrations interfere with GPVI-mediated platelet activation in vitro.

Journal of thrombosis and haemostasis : JTH

Avec: Rohini Sekar , Angelina Mimoun , Melissa Bou-Jaoudeh , Stéphane Loyau , Sandrine Delignat , Victoria Daventure , Perrine Bonilla , Aishwarya Sudam Bahle , Krishnan Venkataraman , Julie Rayes , Yacine Boulaftali , Martine Jandrot-Perrus , Valérie Proulle , Sébastien Lacroix-Desmazes

Binding promiscuity of therapeutic factor VIII.

Thrombosis and haemostasis

Avec: Alejandra Reyes Ruiz , Aishwarya Sudam Bhale , Krishnan Venkataraman , Jordan D Dimitrov , Sebastien Lacroix-Desmazes

The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance.

Folia microbiologica

Avec: Vijay Elakkya Vijayakumar , Mookambeswaran A Vijayalakshmi , Sebastien Lacroix-Desmazes , Krishnan Venkataraman

Réseau de co-auteurs

Sébastien Lacroix-Desmazes 23 collaborations

Sandrine Delignat 14 collaborations

Jordan D Dimitrov 14 collaborations

Maxime Lecerf 7 collaborations

Victoria Daventure 6 collaborations

Srinivas V Kaveri 5 collaborations

Julie Rayes 5 collaborations

Jagadeesh Bayry 5 collaborations

Melissa Bou-Jaoudeh 5 collaborations

Jules Russick 4 collaborations

Cécile V Denis 4 collaborations

Srini V Kaveri 4 collaborations

Angelina Mimoun 4 collaborations

Valérie Proulle 4 collaborations

Peter J Lenting 3 collaborations

Alejandra Reyes Ruiz 3 collaborations

Olivier D Christophe 3 collaborations

Ivan Peyron 3 collaborations

Aditi Varthaman 3 collaborations

Krishnan Venkataraman 3 collaborations

Bagirath Gangadharan 2 collaborations

Jan Voorberg 2 collaborations

Cyril Planchais 2 collaborations

Remi Noe 2 collaborations

Lubka T Roumenina 2 collaborations

Kathleen P Pratt 2 collaborations

Alexia Kanyavuz 2 collaborations

Marie Wiatr 2 collaborations

Rémi Noé 2 collaborations

Claire Deligne 2 collaborations

Peter Milanov 1 collaboration

Olivier Christophe 1 collaboration

Gábor Boros 1 collaboration

Mathieu Ing 1 collaboration

A Nguyen 1 collaboration

Y Repesse 1 collaboration

M Ebbo 1 collaboration

Y Allenbach 1 collaboration

O Benveniste 1 collaboration

J M Vallat 1 collaboration

L Magy 1 collaboration

S Deshayes 1 collaboration

G Maigné 1 collaboration

H de Boysson 1 collaboration

A Karnam 1 collaboration

S Delignat 1 collaboration

S Lacroix-Desmazes 1 collaboration

J Bayry 1 collaboration

A Aouba 1 collaboration

Shailendra Chauhan 1 collaboration

Deepak Kumar Rathore 1 collaboration

Shilpa Sachan 1 collaboration

Nimesh Gupta 1 collaboration

Amit Awasthi 1 collaboration

Sudhanshu Vrati 1 collaboration

Manjula Kalia 1 collaboration

Marie Gilbert 1 collaboration

Valder R Arruda 1 collaboration

Stéphanie Barnay-Verdier 1 collaboration

Chloé Borde 1 collaboration

Lakhdar Fattoum 1 collaboration

Bharath Wootla 1 collaboration

Srini Kaveri 1 collaboration

Sébastien Gibot 1 collaboration

Vincent Maréchal 1 collaboration

Delphine Bachelet 1 collaboration

Thilo Albert 1 collaboration

Cyprien Mbogning 1 collaboration

Signe Hässler 1 collaboration

Yuan Zhang 1 collaboration

Stephan Schultze-Strasser 1 collaboration

Yohann Repessé 1 collaboration

Anna Pavlova 1 collaboration

Behnaz Pezeshkpoor 1 collaboration

Kerstin Liphardt 1 collaboration

Julie E Davidson 1 collaboration

Agnès Hincelin-Méry 1 collaboration

Pierre Dönnes 1 collaboration

Christoph Königs 1 collaboration

Johannes Oldenburg 1 collaboration

Philippe Broët 1 collaboration

None None 1 collaboration

Yesim Dargaud 1 collaboration

Alexandre Leuci 1 collaboration

Marcos D Muñoz 1 collaboration

Lucas J Gutierrez 1 collaboration

Sandra E Gomez Mejiba 1 collaboration

Ricardo D Enriz 1 collaboration

Dario C Ramirez 1 collaboration

David Lillicrap 1 collaboration

David W Scott 1 collaboration

Suryasarathi Dasgupta 1 collaboration

Maya Hadzhieva 1 collaboration

Sune Justesen 1 collaboration

Marie-Agnès Dragon-Durey 1 collaboration

Nicolas S Merle 1 collaboration

Idris Boudhabhay 1 collaboration

Victoria Poillerat 1 collaboration

Sofia Rossini 1 collaboration

Sébastian Lacroix-Desmazes 1 collaboration

Annaelle Marey-Jarossay 1 collaboration

Mohan S Maddur 1 collaboration

Michel D Kazatchkine 1 collaboration

Jan Astermark 1 collaboration

Hervé Lévesque 1 collaboration

Aurélien Azam 1 collaboration

Jenny McIntosh 1 collaboration

Amit C Nathwani 1 collaboration

Ladislas Capdevila 1 collaboration

Mélissa Bou Jaoudeh 1 collaboration

Christian Leborgne 1 collaboration

Elena Barbon 1 collaboration

Jeffrey M Alexander 1 collaboration

Hayley Hanby 1 collaboration

Daniel M Cohen 1 collaboration

Fanny Collaud 1 collaboration

Saghana Muraleetharan 1 collaboration

Dan Lupo 1 collaboration

Joseph Silverberg 1 collaboration

Karen Huang 1 collaboration

Laetitia van Wittengerghe 1 collaboration

Béatrice Marolleau 1 collaboration

Adeline Miranda 1 collaboration

Anna Fabiano 1 collaboration

Heena Beck 1 collaboration

Xavier M Anguela 1 collaboration

Giuseppe Ronzitti 1 collaboration

Sean M Armour 1 collaboration

Federico Mingozzi 1 collaboration

Shina Pashova 1 collaboration

Anastas Pashov 1 collaboration

Shannon L Meeks 1 collaboration

Anupama Karnam 1 collaboration

Naresh Rambabu 1 collaboration

Mrinmoy Das 1 collaboration

Fabian Käsermann 1 collaboration

Nina Bozinovic 1 collaboration

Sébastien Sanges 1 collaboration

Emmanuelle Jeanpierre 1 collaboration

Benjamin Lopez 1 collaboration

Benjamin Carpentier 1 collaboration

Romain Dubois 1 collaboration

Sylvain Dubucquoi 1 collaboration

Thomas Guerrier 1 collaboration

Éric Hachulla 1 collaboration

Pierre-Yves Hatron 1 collaboration

Camille Paris 1 collaboration

Sophie Susen 1 collaboration

David Launay 1 collaboration

Louis Terriou 1 collaboration

Rohini Sekar 1 collaboration

Stéphane Loyau 1 collaboration

Perrine Bonilla 1 collaboration

Aishwarya Sudam Bahle 1 collaboration

Yacine Boulaftali 1 collaboration

Martine Jandrot-Perrus 1 collaboration

Aishwarya Sudam Bhale 1 collaboration

Vijay Elakkya Vijayakumar 1 collaboration

Mookambeswaran A Vijayalakshmi 1 collaboration