questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Globulines
Sérum-globulines
Immunoglobulines
Anticorps
Anticorps : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Anticorps
Tests sérologiques
Anticorps
Immunofluorescence
Symptômes
5
Réponse immunitaire
Symptômes
Anticorps
Maladies infectieuses
Anticorps
Maladies auto-immunes
Anticorps
Infections virales
Prévention
5
Système immunitaire
Prévention
COVID-19
Anticorps monoclonaux
Traitements
5
Anticorps monoclonaux
Thérapie
Anticorps
Prévention des maladies
Anticorps
Effets secondaires
Complications
5
Anticorps
Maladies auto-immunes
Anticorps
Réactions allergiques
Anticorps monoclonaux
Complications
Anticorps
Interactions médicamenteuses
Maladies auto-immunes
Complications
Facteurs de risque
5
Facteurs de risque
Maladies auto-immunes
Habitudes alimentaires
Anticorps
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"name": "Traitements",
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"description": "Comment les anticorps sont-ils utilisés en thérapie ?\nLes anticorps peuvent-ils être administrés par injection ?\nQu'est-ce que l'immunothérapie par anticorps ?\nLes anticorps peuvent-ils être utilisés pour prévenir des maladies ?\nQuels sont les effets secondaires des traitements par anticorps ?",
"url": "https://questionsmedicales.fr/mesh/D000906?mesh_terms=Linear+Energy+Transfer#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Anticorps",
"description": "Quels sont les risques d'une surproduction d'anticorps ?\nLes anticorps peuvent-ils causer des réactions allergiques ?\nQuelles complications peuvent survenir avec des anticorps monoclonaux ?\nLes anticorps peuvent-ils interférer avec d'autres traitements ?\nQuelles sont les complications des maladies auto-immunes ?",
"url": "https://questionsmedicales.fr/mesh/D000906?mesh_terms=Linear+Energy+Transfer#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Anticorps",
"description": "Quels facteurs augmentent le risque de maladies auto-immunes ?\nLe stress influence-t-il la production d'anticorps ?\nL'âge influence-t-il la réponse des anticorps ?\nLes infections antérieures affectent-elles la production d'anticorps ?\nLes habitudes alimentaires influencent-elles les anticorps ?",
"url": "https://questionsmedicales.fr/mesh/D000906?mesh_terms=Linear+Energy+Transfer#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment détecte-t-on les anticorps dans le sang ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "On utilise des tests sérologiques comme l'ELISA pour mesurer les anticorps."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour les anticorps spécifiques ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests comme l'immunofluorescence ou les tests d'agglutination sont utilisés."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils indiquer une infection ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la présence d'anticorps spécifiques peut indiquer une infection antérieure."
}
},
{
"@type": "Question",
"name": "Qu'est-ce qu'un titre d'anticorps ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "C'est une mesure de la concentration d'anticorps dans le sang, indiquant l'immunité."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils être détectés chez les nouveau-nés ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les anticorps maternels peuvent être détectés chez les nouveau-nés."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une réponse immunitaire ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, fatigue, et inflammation peuvent indiquer une réponse immunitaire active."
}
},
{
"@type": "Question",
"name": "Les anticorps causent-ils des symptômes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ce sont les maladies ou infections que les anticorps combattent qui causent des symptômes."
}
},
{
"@type": "Question",
"name": "Comment les anticorps affectent-ils les allergies ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les anticorps IgE sont impliqués dans les réactions allergiques, provoquant des symptômes."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils causer des maladies auto-immunes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anticorps peuvent attaquer les tissus sains, entraînant des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Quels anticorps sont liés aux infections virales ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les anticorps IgM et IgG sont souvent associés aux infections virales."
}
},
{
"@type": "Question",
"name": "Comment les vaccins stimulent-ils la production d'anticorps ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccins introduisent des antigènes, entraînant la production d'anticorps spécifiques."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils être transférés par le lait maternel ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les anticorps maternels sont transférés au bébé par le lait maternel, offrant une protection."
}
},
{
"@type": "Question",
"name": "Comment maintenir un système immunitaire fort ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée, l'exercice et le sommeil aident à maintenir un système immunitaire fort."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils être utilisés pour prévenir le COVID-19 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements par anticorps monoclonaux sont utilisés pour prévenir les formes graves du COVID-19."
}
},
{
"@type": "Question",
"name": "Les anticorps sont-ils efficaces contre toutes les infections ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, leur efficacité dépend du type d'infection et de la réponse immunitaire individuelle."
}
},
{
"@type": "Question",
"name": "Comment les anticorps sont-ils utilisés en thérapie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anticorps monoclonaux sont utilisés pour traiter diverses maladies, y compris le cancer."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils être administrés par injection ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les anticorps peuvent être administrés par injection pour traiter certaines maladies."
}
},
{
"@type": "Question",
"name": "Qu'est-ce que l'immunothérapie par anticorps ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "C'est un traitement qui utilise des anticorps pour renforcer la réponse immunitaire contre le cancer."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils être utilisés pour prévenir des maladies ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anticorps spécifiques peuvent être administrés pour prévenir certaines infections."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires des traitements par anticorps ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure des réactions allergiques et des infections."
}
},
{
"@type": "Question",
"name": "Quels sont les risques d'une surproduction d'anticorps ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surproduction peut entraîner des maladies auto-immunes ou des allergies graves."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils causer des réactions allergiques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains anticorps peuvent provoquer des réactions allergiques en réponse à des allergènes."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anticorps monoclonaux ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des infections, des réactions allergiques et des effets secondaires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les anticorps peuvent-ils interférer avec d'autres traitements ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains anticorps peuvent interagir avec d'autres médicaments, affectant leur efficacité."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications des maladies auto-immunes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des dommages aux organes, des infections et une qualité de vie réduite."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de maladies auto-immunes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et hormonaux peuvent augmenter ce risque."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il la production d'anticorps ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la réponse immunitaire et la production d'anticorps."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la réponse des anticorps ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la réponse des anticorps peut diminuer avec l'âge, rendant les personnes âgées plus vulnérables."
}
},
{
"@type": "Question",
"name": "Les infections antérieures affectent-elles la production d'anticorps ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections antérieures peuvent influencer la mémoire immunitaire et la production d'anticorps."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles les anticorps ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en nutriments peut soutenir la production d'anticorps et la santé immunitaire."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 25/04/2025
Contenu vérifié selon les dernières recommandations médicales
└─
Anticorps anti-idiotypiques
Antibodies, Anti-Idiotypic
D000888
-
D12.776.377.715.548.114.071
└─
Anticorps anti-archéens
Antibodies, Archaeal
D019844
-
D12.776.377.715.548.114.107
└─
Anticorps antibactériens
Antibodies, Bacterial
D000907
-
D12.776.377.715.548.114.125
└─
Anticorps bispécifiques
Antibodies, Bispecific
D018033
-
D12.776.377.715.548.114.134
└─
Anticorps bloquants
Antibodies, Blocking
D019138
-
D12.776.377.715.548.114.143
└─
Anticorps catalytiques
Antibodies, Catalytic
D017151
-
D12.776.377.715.548.114.167
└─
Anticorps antifongiques
Antibodies, Fungal
D000908
-
D12.776.377.715.548.114.179
└─
Anticorps antihelminthe
Antibodies, Helminth
D000909
-
D12.776.377.715.548.114.185
└─
Anticorps hétérophiles
Antibodies, Heterophile
D000910
-
D12.776.377.715.548.114.191
└─
Anticorps monoclonaux
Antibodies, Monoclonal
D000911
-
D12.776.377.715.548.114.224
└─
Anticorps antitumoraux
Antibodies, Neoplasm
D000912
-
D12.776.377.715.548.114.240
└─
Anticorps neutralisants
Antibodies, Neutralizing
D057134
-
D12.776.377.715.548.114.244
└─
Anticorps phospho-spécifiques
Antibodies, Phospho-Specific
D045163
-
D12.776.377.715.548.114.248
└─
Anticorps antiprotozoaires
Antibodies, Protozoan
D000913
-
D12.776.377.715.548.114.252
└─
Anticorps antiviraux
Antibodies, Viral
D000914
-
D12.776.377.715.548.114.254
└─
Autoanticorps
Autoantibodies
D001323
-
D12.776.377.715.548.114.323
└─
Isotypes des immunoglobulines
Immunoglobulin Isotypes
D007132
-
D12.776.377.715.548.114.619
└─
Immunoglobulines par voie veineuse
Immunoglobulins, Intravenous
D016756
-
D12.776.377.715.548.114.632
└─
Anticorps anti-insuline
Insulin Antibodies
D007330
-
D12.776.377.715.548.114.656
└─
Alloanticorps
Isoantibodies
D007518
-
D12.776.377.715.548.114.664
└─
Planticorps
Plantibodies
D046549
-
D12.776.377.715.548.114.820
└─
Précipitines
Precipitins
D011234
-
D12.776.377.715.548.114.837
└─
Réagines
Reagins
D011935
-
D12.776.377.715.548.114.890
└─└─
Antistreptolysine
Antistreptolysin
D000989
-
D12.776.377.715.548.114.125.288
└─└─
Anticorps monoclonaux humanisés
Antibodies, Monoclonal, Humanized
D061067
-
D12.776.377.715.548.114.224.200
└─└─
Anticorps monoclonaux d'origine murine
Antibodies, Monoclonal, Murine-Derived
D058846
-
D12.776.377.715.548.114.224.284
└─└─
Infliximab
Infliximab
D000069285
-
D12.776.377.715.548.114.224.642
└─└─
Anticorps neutralisants à large spectre
Broadly Neutralizing Antibodies
D000080908
-
D12.776.377.715.548.114.244.500
└─└─
Anticorps antideltarétrovirus
Deltaretrovirus Antibodies
D015480
-
D12.776.377.715.548.114.254.150
└─└─
Anticorps de l'hépatite
Hepatitis Antibodies
D006508
-
D12.776.377.715.548.114.254.450
└─└─
Anticorps anti-protéines citrullinées
Anti-Citrullinated Protein Antibodies
D000075422
-
D12.776.377.715.548.114.323.095
└─└─
Anticorps antinucléaires
Antibodies, Antinuclear
D000974
-
D12.776.377.715.548.114.323.204
└─└─
Anticorps antiphospholipides
Antibodies, Antiphospholipid
D017152
-
D12.776.377.715.548.114.323.210
└─└─
Facteur néphritique C3
Complement C3 Nephritic Factor
D003178
-
D12.776.377.715.548.114.323.300
└─└─
Immunoconglutinines
Immunoconglutinins
D037561
-
D12.776.377.715.548.114.323.390
└─└─
Immunoglobulines thyréostimulantes
Immunoglobulins, Thyroid-Stimulating
D018828
-
D12.776.377.715.548.114.323.480
└─└─
Facteur rhumatoïde
Rheumatoid Factor
D012217
-
D12.776.377.715.548.114.323.732
└─└─
Abatacept
Abatacept
D000069594
-
D12.776.377.715.548.114.580.225
└─└─
Immunoglobuline A
Immunoglobulin A
D007070
-
D12.776.377.715.548.114.619.026
└─└─
Immunoglobuline D
Immunoglobulin D
D007072
-
D12.776.377.715.548.114.619.251
└─└─
Immunoglobuline E
Immunoglobulin E
D007073
-
D12.776.377.715.548.114.619.312
└─└─
Immunoglobuline G
Immunoglobulin G
D007074
-
D12.776.377.715.548.114.619.393
└─└─
Immunoglobuline M
Immunoglobulin M
D007075
-
D12.776.377.715.548.114.619.574
└─└─└─
Adalimumab
Adalimumab
D000068879
-
D12.776.377.715.548.114.224.200.250
└─└─└─
Alemtuzumab
Alemtuzumab
D000074323
-
D12.776.377.715.548.114.224.200.375
└─└─└─
Basiliximab
Basiliximab
D000077552
-
D12.776.377.715.548.114.224.200.407
└─└─└─
Bévacizumab
Bevacizumab
D000068258
-
D12.776.377.715.548.114.224.200.438
└─└─└─
Brentuximab védotine
Brentuximab Vedotin
D000079963
-
D12.776.377.715.548.114.224.200.469
└─└─└─
Cétuximab
Cetuximab
D000068818
-
D12.776.377.715.548.114.224.200.750
└─└─└─
Daclizumab
Daclizumab
D000077561
-
D12.776.377.715.548.114.224.200.766
└─└─└─
Dénosumab
Denosumab
D000069448
-
D12.776.377.715.548.114.224.200.782
└─└─└─
Gemtuzumab
Gemtuzumab
D000079982
-
D12.776.377.715.548.114.224.200.790
└─└─└─
Inotuzumab ozogamicine
Inotuzumab Ozogamicin
D000080045
-
D12.776.377.715.548.114.224.200.794
└─└─└─
Ipilimumab
Ipilimumab
D000074324
-
D12.776.377.715.548.114.224.200.798
└─└─└─
Natalizumab
Natalizumab
D000069442
-
D12.776.377.715.548.114.224.200.813
└─└─└─
Nivolumab
Nivolumab
D000077594
-
D12.776.377.715.548.114.224.200.829
└─└─└─
Omalizumab
Omalizumab
D000069444
-
D12.776.377.715.548.114.224.200.844
└─└─└─
Palivizumab
Palivizumab
D000069455
-
D12.776.377.715.548.114.224.200.860
└─└─└─
Panitumumab
Panitumumab
D000077544
-
D12.776.377.715.548.114.224.200.864
└─└─└─
Ranibizumab
Ranibizumab
D000069579
-
D12.776.377.715.548.114.224.200.868
└─└─└─
Trastuzumab
Trastuzumab
D000068878
-
D12.776.377.715.548.114.224.200.875
└─└─└─
Ustékinumab
Ustekinumab
D000069549
-
D12.776.377.715.548.114.224.200.937
└─└─└─
Rituximab
Rituximab
D000069283
-
D12.776.377.715.548.114.224.284.785
└─└─└─
Anticorps anti-VIH
HIV Antibodies
D015483
-
D12.776.377.715.548.114.254.150.440
└─└─└─
Anticorps anti-HTLVI
HTLV-I Antibodies
D015481
-
D12.776.377.715.548.114.254.150.500
└─└─└─
Anticorps anti-HTLVII
HTLV-II Antibodies
D015482
-
D12.776.377.715.548.114.254.150.510
└─└─└─
Anticorps de l'hépatite A
Hepatitis A Antibodies
D035922
-
D12.776.377.715.548.114.254.450.251
└─└─└─
Anticorps de l'hépatite B
Hepatitis B Antibodies
D006510
-
D12.776.377.715.548.114.254.450.504
└─└─└─
Anticorps de l'hépatite C
Hepatitis C Antibodies
D018937
-
D12.776.377.715.548.114.254.450.510
└─└─└─
Anticorps anticardiolipines
Antibodies, Anticardiolipin
D017153
-
D12.776.377.715.548.114.323.210.100
└─└─└─
Immunoglobuline A sécrétoire
Immunoglobulin A, Secretory
D007071
-
D12.776.377.715.548.114.619.026.030
└─└─└─
LATS
Long-Acting Thyroid Stimulator
D008135
-
D12.776.377.715.548.114.619.393.550
└─└─└─
Muromonab-CD3
Muromonab-CD3
D016853
-
D12.776.377.715.548.114.619.393.570
└─└─└─
Immunoglobuline Rh
Rho(D) Immune Globulin
D018029
-
D12.776.377.715.548.114.619.393.700
└─└─└─└─
Ado-trastuzumab emtansine
Ado-Trastuzumab Emtansine
D000080044
-
D12.776.377.715.548.114.224.200.875.500
3 publications dans cette catégorie
Affiliations :
Center for Research in Biological Systems, University of California , La Jolla, CA, USA.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
National Center for Parasitology, Entomology, and Malaria Control, Ministry of Health, Phnom Penh, Cambodia.
National Dengue Control Program, Ministry of Health, Phnom Penh, Cambodia.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
National Center for Parasitology, Entomology, and Malaria Control, Ministry of Health, Phnom Penh, Cambodia.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
2 publications dans cette catégorie
Affiliations :
International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Publications dans "Anticorps" :
The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis...
We quantified the effect of various forward-based treatment-planning strategies in proton therapy on dose-weighted linear energy transfer (LETd). By maintaining the dosimetric quality at a clinically ...
Eight treatment-planning strategies that are achievable in commercial treatment-planning systems were applied on a cylindrical water phantom and four pediatric brain tumor cases. Each planning strateg...
In the phantom study, using a range shifter and altering the robust scenarios during optimization had the largest effect on the mean clinical target volume LETd, which was reduced from 4.5 to 3.9 keV/...
Changes in LETd from treatment-plan setup follow intuitive trends in a controlled phantom experiment. Anatomical and other patient-specific considerations, however, can preclude generalizable strategi...
Compelling evidence shows the association between the relative biological effectiveness (RBE) of carbon-ion radiotherapy (CIRT) and the dose averaged linear energy transfer (LETd). However, the abilit...
This study aims to develop a method of calculating the LETd of CIRT plans that could be robustly carried out in RayStation (V10B, Raysearch, Sweden)....
The calculation used the fragment spectra in RayStation for the CIRT treatment planning. The dose-weighted averaging procedure was supported by the microdosimetric kinetic model (MKM). The MKM-based p...
The differences in LETds of the monoenergetic beams between the new method and the traditional method were within 3% in the entrance and Bragg-peak regions. However, a larger difference was observed i...
The method presented herein reformulates the MKM dose engine in the RayStation TPS to inversely calculate LETds. The robustness and accuracy were demonstrated....
The precise assessment of the dose distribution of high linear energy transfer (LET) radiation remains a challenge, because the signal of most dosimeters will be saturated due to the high ionization d...
Nanoclay radio-fluorogenic gel (NC-RFG) dosimeters were prepared, typically containing 100 μM dihydrorhodamine 123 (DHR123) and 2.0 wt% nanoclay together with catalytic additives promoting Fenton or F...
An NC-RFG dosimeter capable of generating a fluorescence intensity distribution reflecting the carbon-ion beam dose profile was obtained. It was clarified that the reduction of the unfavorable LET dep...
This technique allows the first-ever evaluation of the depth-dose profile of a carbon-ion beam at typical therapeutic levels of several Gy without LET effect....
In modern radiotherapy with photons, the absorbed dose outside the radiation field is generally investigated. But it is well known that the biological damage depends not only on the absorbed dose but ...
The use of radiation with low and high linear energy transfer (LET) in the same treatment regimen is promising in terms of increasing the efficiency and reducing the severity of radiation complication...
Different alpha exposure setups are often used to study the relation between biological responses and LET. This study aimed to estimate the dose heterogeneity and uncertainty in four exposure setups u...
Geant4 was used to estimate the dose distributions in cells grown on a disk exposed to alpha particles penetrating from above and below. The latter setup was simulated without and with a collimator. P...
The LET distributions obtained for simulated setups excluding the collimator were wide and non-Gaussian. Using a collimator resulted in a Gaussian LET distribution, but strongly reduced dose rate and ...
The interpretation of results from radiobiological experiments with alpha particles should always cover the characteristics of the experimental setup, which can be done precisely with computational me...
The correlation between dose-averaged linear energy transfer (LETd) and its therapeutic or adverse effects, especially in carbon-ion radiotherapy (CIRT), remains controversial. This study aimed to inv...
Among patients who underwent CIRT for uterine carcinoma, 101 who were followed up for > 6 months without any other therapy were retrospectively analyzed. The sacrum insufficiency fractures (SIFs) were...
At the last follow-up, 19 patients developed SIFs. Receiver operating characteristic curve analysis revealed that the sacrum D50% RBE-weighted dose was a valuable predictor of SIF. Univariate analyses...
The sacrum D50% RBE-weighted dose was identified as a risk factor for SIF. Additionally, neither LETd nor physical dose parameters were associated with SIF prediction....
The increasing number of studies dealing with linear energy transfer (LET)-based evaluation and optimization in the field of carbon ion radiotherapy (CIRT) indicates the rising demand for LET implemen...
This in silico study was conducted to benchmark the following two LET-related functionalities in a commercial TPS against Monte Carlo simulations: (1) dose averaged LET (LET...
The LET...
For all setups (homogeneous and heterogeneous), the mean absolute (and relative) LET...
No computation error was found in the tested functionalities except for LET...
A fixed relative biological effectiveness (RBE) of 1.1 (RBE...
36 patients treated with passive scattering proton therapy were selected for a case-control study from a cohort of 954 pediatric brain tumor patients. Nine children with symptomatic brainstem toxicity...
LET...
Trends towards higher LET...