Physiology of sedentary behavior.
Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employ...
Protein-arginine N-methyltransferases : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une dysfonction des N-méthyltransférases ?
Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer.
#2
Quels tests sont utilisés pour évaluer l'activité enzymatique ?
Des tests enzymatiques spécifiques mesurent l'activité des N-méthyltransférases dans les échantillons.
#3
Y a-t-il des biomarqueurs associés à ces enzymes ?
Des biomarqueurs comme la méthylation de l'arginine peuvent indiquer une activité enzymatique.
#4
Quels symptômes peuvent indiquer un problème enzymatique ?
Des symptômes variés comme des troubles neurologiques ou immunitaires peuvent survenir.
#5
Comment les tests génétiques aident-ils au diagnostic ?
Ils identifient des mutations spécifiques dans les gènes codant pour ces enzymes.
Symptômes 5
#1
Quels sont les symptômes d'une carence en N-méthyltransférases ?
Les symptômes incluent fatigue, troubles cognitifs et anomalies immunitaires.
#2
Les troubles de l'humeur sont-ils liés à ces enzymes ?
Oui, des déséquilibres peuvent affecter l'humeur et contribuer à des troubles psychiatriques.
#3
Peut-on observer des symptômes neurologiques ?
Oui, des troubles neurologiques comme des convulsions peuvent être présents.
#4
Y a-t-il des symptômes spécifiques chez les enfants ?
Les enfants peuvent présenter des retards de développement et des troubles d'apprentissage.
#5
Comment les symptômes varient-ils selon l'âge ?
Les symptômes peuvent être plus prononcés chez les jeunes enfants et les personnes âgées.
Prévention 5
#1
Comment prévenir les troubles liés aux N-méthyltransférases ?
Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir ces troubles.
#2
Y a-t-il des mesures préventives spécifiques ?
Des dépistages précoces et des conseils génétiques peuvent être bénéfiques.
#3
L'éducation sur la santé est-elle importante ?
Oui, sensibiliser les patients et les familles peut aider à identifier les symptômes tôt.
#4
Les vaccinations jouent-elles un rôle préventif ?
Certaines vaccinations peuvent prévenir des infections qui aggravent les symptômes.
#5
Comment le suivi médical aide-t-il à la prévention ?
Un suivi régulier permet de surveiller l'état de santé et d'ajuster les traitements.
Traitements 5
#1
Quels traitements existent pour les dysfonctionnements enzymatiques ?
Les traitements peuvent inclure des suppléments nutritionnels et des thérapies ciblées.
#2
Les médicaments peuvent-ils aider à réguler ces enzymes ?
Oui, certains médicaments peuvent moduler l'activité des N-méthyltransférases.
#3
Y a-t-il des thérapies géniques disponibles ?
Des recherches sont en cours sur les thérapies géniques pour corriger les mutations.
#4
Comment la nutrition influence-t-elle le traitement ?
Une alimentation riche en nutriments peut soutenir la fonction enzymatique.
#5
Les traitements sont-ils personnalisés ?
Oui, les traitements peuvent être adaptés en fonction des besoins individuels du patient.
Complications 5
#1
Quelles complications peuvent survenir avec ces troubles ?
Des complications neurologiques, immunitaires et métaboliques peuvent se développer.
#2
Les troubles cardiovasculaires sont-ils possibles ?
Oui, des déséquilibres peuvent augmenter le risque de maladies cardiovasculaires.
#3
Comment les complications affectent-elles la qualité de vie ?
Elles peuvent entraîner des limitations fonctionnelles et des besoins de soins accrus.
#4
Y a-t-il des complications à long terme ?
Oui, des complications chroniques peuvent affecter la santé globale et le bien-être.
#5
Les complications peuvent-elles être évitées ?
Certaines complications peuvent être évitées par un traitement précoce et approprié.
Facteurs de risque 5
#1
Quels sont les facteurs de risque associés ?
Les facteurs incluent des antécédents familiaux, des mutations génétiques et des carences nutritionnelles.
#2
L'environnement joue-t-il un rôle ?
Oui, des facteurs environnementaux comme la pollution peuvent influencer la fonction enzymatique.
#3
Le mode de vie affecte-t-il le risque ?
Un mode de vie sédentaire et une mauvaise alimentation augmentent le risque de troubles.
#4
Les infections peuvent-elles être un facteur de risque ?
Certaines infections peuvent exacerber les symptômes et augmenter le risque de complications.
#5
Y a-t-il des groupes à risque spécifiques ?
Les personnes avec des antécédents familiaux ou des troubles métaboliques sont plus à risque.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 23/03/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Y George Zheng
4 publications dans cette catégorie
Affiliations :
- Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States. yzheng@uga.edu.
Publications dans "Protein-arginine N-methyltransferases" :
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Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1.
World journal of biological chemistry
-
The macromolecular complexes of histones affect protein arginine methyltransferase activities.
The Journal of biological chemistry 2021-09-06
-
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Cellular and molecular life sciences : CMLS 2019-05-23
-
Hetero-oligomeric interaction as a new regulatory mechanism for protein arginine methyltransferases.
Biochemical Society transactions 2024-09-26
Adam Frankel
4 publications dans cette catégorie
Affiliations :
- Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: adam.frankel@ubc.ca.
Publications dans "Protein-arginine N-methyltransferases" :
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Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1.
The Journal of biological chemistry 2023-10-19
-
The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.
Methods (San Diego, Calif.) 2019-11-11
-
Protein arginine N-methyltransferase activity determination with filter binding and phosphor screening (FBAPS) assay.
Analytical biochemistry 2022-06-13
-
Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function.
Molecular neurobiology 2019-12-10
Alessandra Feoli
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Giulia Iannelli
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
- PhD Program in Drug Discovery and Development, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Alessandra Cipriano
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Ciro Milite
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Monica Viviano
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Sabrina Castellano
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Gianluca Sbardella
3 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Journal of medicinal chemistry 2022-04-28
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Rong Huang
3 publications dans cette catégorie
Affiliations :
- Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States.
Publications dans "Protein-arginine N-methyltransferases" :
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Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.
Current protein & peptide science
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A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes.
Biomolecules 2021-06-08
-
Chemical Biology of Protein N-Terminal Methyltransferases.
Chembiochem : a European journal of chemical biology 2019-02-13
Shougang Zhuang
3 publications dans cette catégorie
Affiliations :
- Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, U.S.A.
- Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Publications dans "Protein-arginine N-methyltransferases" :
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The role of protein arginine methyltransferases in kidney diseases.
Clinical science (London, England : 1979)
-
Protein arginine methyltransferases in renal development, injury, repair, and fibrosis.
Frontiers in pharmacology 2023-02-03
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The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases.
Frontiers in pharmacology 2022-04-26
Jong-Sun Kang
3 publications dans cette catégorie
Affiliations :
- Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, Korea.
- Single Cell Network Research Center, Sungkyunkwan University, Suwon 16419, Korea.
Publications dans "Protein-arginine N-methyltransferases" :
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Protein Arginine Methyltransferases in Neuromuscular Function and Diseases.
Cells 2022-01-21
-
Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology.
Frontiers in physiology 2021-08-19
-
Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease.
Diabetes & metabolism journal 2024-07-24
Giuliana Sarno
2 publications dans cette catégorie
Affiliations :
- Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
- PhD Program in Drug Discovery and Development, University of Salerno, via Giovanni Paolo II 132, Fisciano ,I-84084 SA Italy.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem 2024-05-16
Steven G Clarke
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, and the Molecular Biology Institute, University of California, Los Angeles, California 90095, United States.
Publications dans "Protein-arginine N-methyltransferases" :
-
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Journal of medicinal chemistry 2023-08-10
-
PRMT7 as a unique member of the protein arginine methyltransferase family: A review.
Archives of biochemistry and biophysics 2019-02-22
Yandong Lai
2 publications dans cette catégorie
Affiliations :
- Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Publications dans "Protein-arginine N-methyltransferases" :
Xiuying Li
2 publications dans cette catégorie
Affiliations :
- Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- Veterans Affairs Pittsburgh Healthcare system, Pittsburgh, Pennsylvania, USA.
Publications dans "Protein-arginine N-methyltransferases" :
Tiao Li
2 publications dans cette catégorie
Affiliations :
- Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Publications dans "Protein-arginine N-methyltransferases" :
Toru Nyunoya
2 publications dans cette catégorie
Affiliations :
- Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- Veterans Affairs Pittsburgh Healthcare system, Pittsburgh, Pennsylvania, USA.
Publications dans "Protein-arginine N-methyltransferases" :
Kong Chen
2 publications dans cette catégorie
Affiliations :
- Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Publications dans "Protein-arginine N-methyltransferases" :
Yingze Zhang
2 publications dans cette catégorie
Affiliations :
- Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Publications dans "Protein-arginine N-methyltransferases" :
Sources (10000 au total)
Sedentary behavior and the biological hallmarks of aging.
While the benefits of physical exercise for a healthy aging are well-recognized, a growing body of evidence shows that sedentary behavior has deleterious health effects independently, to some extent, ...
Sedentary behavior and lifespan brain health.
Higher levels of physical activity are known to benefit aspects of brain health across the lifespan. However, the role of sedentary behavior (SB) is less well understood. In this review we summarize a...
Sedentary Behavior Patterns of the Hungarian Adult Population.
Nowadays, a high level of sedentary behavior (SB) is an important health issue. Many studies have focused on evaluating the physical activity (PA) level, while evaluation of SB has received less atten... This study analyzed cross-sectional primary data using self-reported questionnaires collected by a Hungarian research market company among the adult population in Hungary. The final sample of this stu... According to the SBQ, on average, Hungarians sit for 469.53 min per day (7.81 h) on weekdays and 421.25 min per day (7.01 h) on weekends, which suggested a significant difference compared to IPAQ data...
Screen-based sedentary behaviors but not total sedentary time are associated with anxiety among college students.
The purpose of the study was to investigate the associations of device-measured total sedentary time and screen-based sedentary time with anxiety in college students.... Three hundred and twenty-one college students (mean age = 19.72 ± 1.18, 55.8% females) were recruited from Shanghai, China. Total sedentary time was objectively measured using accelerometry, while scr... Accelerometer-assessed total sedentary time was not associated with anxiety symptom. Prolonged sedentary time on TV and movie viewing (>2 h on weekdays) and social media using (>2 h on weekdays and we... The findings indicated that screen-based sedentary behaviors but not total sedentary time were associated with anxiety symptom among college students. The associations of screen-based sedentary behavi...
A Review of Sedentary Behavior Assessment in National Surveillance Systems.
Temporal changes in sedentary behavior patterns reflect the evolving nature of our built and social environments, particularly the expanding availability of electronic media. It is important to unders... We reviewed questionnaires from national surveillance systems listed on the Global Observatory for Physical Activity (GoPA!) country cards to locate items on sedentary behavior. Questionnaire characte... Overall, 346 surveillance systems were screened for eligibility, of which 93 were included in this review. Most questionnaires used a single-item direct measure of sitting time (n = 78, 84%). Work and... National surveillance systems should be periodically reviewed in response to evidence on contemporary behavior patterns in the population and the release of updated public health guidelines....
The relationship between sedentary behavior and dry eye disease.
Sedentary behavior (SB) has been linked with low-grade systemic inflammation, which could play a role in the development of dry eye disease (DED). This cross-sectional study aims to investigate the as... We assessed 48,418 participants from the population-based Lifelines cohort (58% female, 18-96 years). Women's Health Study (WHS)-defined DED was the primary outcome. SB was assessed using the Marshall... WHS-defined DED was present in 9.1% of participants. Greater SB was associated with an increased risk of DED (odds ratio (OR) 1.015 per hour/day, 95%CI 1.005-1.024, P = 0.004). The association between... Greater sedentary time was tied to an increased risk of DED, especially for those with lower PA levels than WHO recommendations. However, as there was no significant association when computer-intensiv...
Correlates of sedentary behavior in people with fibromyalgia: A systematic review.
Understanding the correlates of sedentary behavior (SB) is important in the development of interventions which reduce and interrupt SB in people with fibromyalgia (PwF). This systematic review aimed t... Three databases (Embase, CINAHL and PubMed) were search from inception until July 21, 2022 using "sedentary" or different types of SB and "fibromyalgia" or "fibrositis" as keywords. The data collected... Out of 23 SB correlates retrieved from 7 reports (n = 1698), no correlates were consistently reported (ie, reported in 4 or more studies). Higher pain intensity was the most commonly reported barrier ... Research on correlates of SB in PwF is still in its infancy. The current preliminary evidence suggests that clinicians should consider physical and mental barriers when aiming to reduce or interrupt S...
Physical activity and sedentary behaviors in Polish children and adolescents.
Participating in physical activity (PA) is essential for children's proper development. Promoting physical activity from early school years is considered a highly important prevention task for good he... Survey study to assess children's and adolescents' physical activity and sedentary behavior were based on a parent-reported questionnaire.... A total of 2913 children and adolescents aged 6-17 years (average age, 11.38 years) from Wroclaw, Poland, who participated in a pro-health campaign "Let's Get the Kids Moving." This project promotes a... The frequency of physical activity significantly decreased as children grew older (p < 0.0001). As many as 18.6% of adolescents 13-17 years old undertook the recommended level of physical activity les... Polish children and adolescents do not spend the recommended level of time on physical activity and spend excessive time in front of the television and other electronic devices. The level of physical ...
Sedentary behavior and cancer-an umbrella review and meta-analysis.
Several systematic reviews and meta-analyses have summarized the association between sedentary behavior (SB) and cancer. However, the level of evidence and the potential for risk of bias remains uncle...