Titre : Protein-tyrosine kinases

Protein-tyrosine kinases : Questions médicales fréquentes

Nom anglais: Protein-Tyrosine Kinases

Descriptor UI: D011505

Tree Number: D12.776.476.568

Termes MeSH sélectionnés :

Keratoconus

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une dysrégulation des kinases à tyrosine ?

Des tests sanguins et des biopsies peuvent révéler des anomalies dans l'activité des kinases.
Kinases Biopsie Tests sanguins
#2

Quels marqueurs sont utilisés pour le diagnostic ?

Les marqueurs tumoraux comme le CA 19-9 peuvent indiquer une activité kinase anormale.
Marqueurs tumoraux Kinases CA 19-9
#3

Les tests génétiques sont-ils utiles ?

Oui, ils peuvent identifier des mutations dans les gènes codant pour les kinases à tyrosine.
Tests génétiques Mutations Kinases
#4

Quels examens d'imagerie sont recommandés ?

L'IRM et le scanner peuvent aider à visualiser les tumeurs associées aux kinases.
IRM Scanner Tumeurs
#5

Les antécédents familiaux influencent-ils le diagnostic ?

Oui, des antécédents de cancers peuvent augmenter le risque de dysrégulation des kinases.
Antécédents familiaux Cancer Kinases

Symptômes 5

#1

Quels symptômes sont liés à une suractivité des kinases ?

Fatigue, perte de poids, et douleurs osseuses peuvent indiquer une suractivité des kinases.
Fatigue Perte de poids Kinases
#2

Les symptômes varient-ils selon le type de kinase ?

Oui, les symptômes dépendent du type de kinase et de la voie de signalisation affectée.
Kinases Voies de signalisation Symptômes
#3

Y a-t-il des symptômes spécifiques aux cancers ?

Oui, des symptômes comme des masses palpables ou des saignements peuvent survenir.
Cancers Masse palpable Saignements
#4

Les symptômes peuvent-ils être confondus avec d'autres maladies ?

Oui, des symptômes comme la fatigue peuvent être communs à plusieurs maladies.
Fatigue Maladies Symptômes
#5

Comment les symptômes évoluent-ils dans le temps ?

Ils peuvent s'aggraver progressivement, nécessitant une surveillance régulière.
Évolution des symptômes Surveillance Kinases

Prévention 5

#1

Peut-on prévenir les dysfonctionnements des kinases ?

Une alimentation saine et l'exercice régulier peuvent réduire le risque de cancers.
Prévention Alimentation saine Exercice
#2

Les dépistages réguliers sont-ils recommandés ?

Oui, des dépistages peuvent aider à détecter précocement des anomalies liées aux kinases.
Dépistage Anomalies Kinases
#3

Y a-t-il des vaccins préventifs ?

Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des kinases.
Vaccins Prévention Kinases
#4

Le tabagisme influence-t-il le risque ?

Oui, le tabagisme est un facteur de risque connu pour plusieurs cancers liés aux kinases.
Tabagisme Facteurs de risque Kinases
#5

Les facteurs environnementaux jouent-ils un rôle ?

Oui, l'exposition à des substances chimiques peut augmenter le risque de dysfonctionnement des kinases.
Facteurs environnementaux Substances chimiques Kinases

Traitements 5

#1

Quels traitements ciblent les kinases à tyrosine ?

Les inhibiteurs de kinases, comme l'imatinib, sont utilisés pour traiter certains cancers.
Inhibiteurs de kinases Imatinib Traitements
#2

Les traitements sont-ils personnalisés ?

Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des kinases.
Traitements personnalisés Mutations Kinases
#3

Quels effets secondaires des traitements sont courants ?

Fatigue, nausées et éruptions cutanées sont des effets secondaires fréquents.
Effets secondaires Fatigue Nausées
#4

La radiothérapie est-elle utilisée ?

Oui, la radiothérapie peut être utilisée en complément des traitements ciblés.
Radiothérapie Traitements ciblés Kinases
#5

Les traitements sont-ils efficaces à long terme ?

L'efficacité varie, mais certains patients peuvent bénéficier d'une rémission prolongée.
Efficacité des traitements Rémission Kinases

Complications 5

#1

Quelles complications peuvent survenir avec les kinases ?

Des complications comme la résistance aux traitements et la progression de la maladie peuvent survenir.
Complications Résistance aux traitements Progression de la maladie
#2

Les complications sont-elles réversibles ?

Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
Complications Gestion Kinases
#3

Comment les complications affectent-elles le pronostic ?

Les complications peuvent aggraver le pronostic et réduire les chances de rémission.
Pronostic Complications Rémission
#4

Les complications varient-elles selon le type de cancer ?

Oui, les complications peuvent différer selon le type de cancer et la kinase impliquée.
Type de cancer Complications Kinases
#5

Les complications nécessitent-elles des traitements supplémentaires ?

Oui, des traitements supplémentaires peuvent être nécessaires pour gérer les complications.
Traitements supplémentaires Complications Kinases

Facteurs de risque 5

#1

Quels sont les principaux facteurs de risque ?

Les antécédents familiaux, le tabagisme et l'exposition à des produits chimiques sont des facteurs de risque.
Facteurs de risque Antécédents familiaux Tabagisme
#2

L'âge influence-t-il le risque de dysfonctionnement des kinases ?

Oui, le risque augmente généralement avec l'âge, surtout pour certains cancers.
Âge Risque Kinases
#3

Le mode de vie joue-t-il un rôle ?

Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.
Mode de vie Risque Kinases
#4

Les infections peuvent-elles être un facteur de risque ?

Certaines infections virales, comme le virus d'Epstein-Barr, peuvent augmenter le risque.
Infections Virus d'Epstein-Barr Risque
#5

Y a-t-il des facteurs génétiques impliqués ?

Oui, des mutations génétiques héréditaires peuvent prédisposer à des dysfonctionnements des kinases.
Facteurs génétiques Mutations Kinases
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Protein-tyrosine kinases : Questions médicales les plus fréquentes", "headline": "Protein-tyrosine kinases : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Protein-tyrosine kinases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-05-05", "dateModified": "2025-04-30", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Protein-tyrosine kinases" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Protéines et peptides de signalisation intracellulaire", "url": "https://questionsmedicales.fr/mesh/D047908", "about": { "@type": "MedicalCondition", "name": "Protéines et peptides de signalisation intracellulaire", "code": { "@type": "MedicalCode", "code": "D047908", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Agammaglobulinaemia tyrosine kinase", "alternateName": "Agammaglobulinaemia Tyrosine Kinase", "url": "https://questionsmedicales.fr/mesh/D000077329", "about": { "@type": "MedicalCondition", "name": "Agammaglobulinaemia tyrosine kinase", "code": { "@type": "MedicalCode", "code": "D000077329", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.025" } } }, { "@type": "MedicalWebPage", "name": "Focal adhesion protein-tyrosine kinases", "alternateName": "Focal Adhesion Protein-Tyrosine Kinases", "url": "https://questionsmedicales.fr/mesh/D051416", "about": { "@type": "MedicalCondition", "name": "Focal adhesion protein-tyrosine kinases", "code": { "@type": "MedicalCode", "code": "D051416", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.049" } } }, { "@type": "MedicalWebPage", "name": "Janus kinases", "alternateName": "Janus Kinases", "url": "https://questionsmedicales.fr/mesh/D053612", "about": { "@type": "MedicalCondition", "name": "Janus kinases", "code": { "@type": "MedicalCode", "code": "D053612", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Janus kinase 1", "alternateName": "Janus Kinase 1", "url": "https://questionsmedicales.fr/mesh/D053613", "about": { "@type": "MedicalCondition", "name": "Janus kinase 1", "code": { "@type": "MedicalCode", "code": "D053613", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124.100" } } }, { "@type": "MedicalWebPage", "name": "Janus kinase 3", "alternateName": "Janus Kinase 3", "url": "https://questionsmedicales.fr/mesh/D053616", "about": { "@type": "MedicalCondition", "name": "Janus kinase 3", "code": { "@type": "MedicalCode", "code": "D053616", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124.300" } } }, { "@type": "MedicalWebPage", "name": "TYK2 Kinase", "alternateName": "TYK2 Kinase", "url": "https://questionsmedicales.fr/mesh/D053634", "about": { "@type": "MedicalCondition", "name": "TYK2 Kinase", "code": { "@type": "MedicalCode", "code": "D053634", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124.650" } } } ] }, { "@type": "MedicalWebPage", "name": "Mitogen-Activated Protein Kinase Kinases", "alternateName": "Mitogen-Activated Protein Kinase Kinases", "url": "https://questionsmedicales.fr/mesh/D020929", "about": { "@type": "MedicalCondition", "name": "Mitogen-Activated Protein Kinase Kinases", "code": { "@type": "MedicalCode", "code": "D020929", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 1", "alternateName": "MAP Kinase Kinase 1", "url": "https://questionsmedicales.fr/mesh/D048369", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 1", "code": { "@type": "MedicalCode", "code": "D048369", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.100" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 2", "alternateName": "MAP Kinase Kinase 2", "url": "https://questionsmedicales.fr/mesh/D048370", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 2", "code": { "@type": "MedicalCode", "code": "D048370", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.200" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 3", "alternateName": "MAP Kinase Kinase 3", "url": "https://questionsmedicales.fr/mesh/D048371", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 3", "code": { "@type": "MedicalCode", "code": "D048371", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.300" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 4", "alternateName": "MAP Kinase Kinase 4", "url": "https://questionsmedicales.fr/mesh/D048670", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 4", "code": { "@type": "MedicalCode", "code": "D048670", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.400" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 5", "alternateName": "MAP Kinase Kinase 5", "url": "https://questionsmedicales.fr/mesh/D048671", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 5", "code": { "@type": "MedicalCode", "code": "D048671", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.500" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 6", "alternateName": "MAP Kinase Kinase 6", "url": "https://questionsmedicales.fr/mesh/D048669", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 6", "code": { "@type": "MedicalCode", "code": "D048669", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.600" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 7", "alternateName": "MAP Kinase Kinase 7", "url": "https://questionsmedicales.fr/mesh/D048688", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 7", "code": { "@type": "MedicalCode", "code": "D048688", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.700" } } } ] }, { "@type": "MedicalWebPage", "name": "Syk kinase", "alternateName": "Syk Kinase", "url": "https://questionsmedicales.fr/mesh/D000072377", "about": { "@type": "MedicalCondition", "name": "Syk kinase", "code": { "@type": "MedicalCode", "code": "D000072377", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.650" } } }, { "@type": "MedicalWebPage", "name": "src-Family kinases", "alternateName": "src-Family Kinases", "url": "https://questionsmedicales.fr/mesh/D019061", "about": { "@type": "MedicalCondition", "name": "src-Family kinases", "code": { "@type": "MedicalCode", "code": "D019061", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.800" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "CSK tyrosine-protein kinase", "alternateName": "CSK Tyrosine-Protein Kinase", "url": "https://questionsmedicales.fr/mesh/D000081247", "about": { "@type": "MedicalCondition", "name": "CSK tyrosine-protein kinase", "code": { "@type": "MedicalCode", "code": "D000081247", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.800.158" } } } ] }, { "@type": "MedicalWebPage", "name": "ZAP-70 Protein-tyrosine kinase", "alternateName": "ZAP-70 Protein-Tyrosine Kinase", "url": "https://questionsmedicales.fr/mesh/D051746", "about": { "@type": "MedicalCondition", "name": "ZAP-70 Protein-tyrosine kinase", "code": { "@type": "MedicalCode", "code": "D051746", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.900" } } } ], "about": { "@type": "MedicalCondition", "name": "Protein-tyrosine kinases", "alternateName": "Protein-Tyrosine Kinases", "code": { "@type": "MedicalCode", "code": "D011505", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Angela L Tyner", "url": "https://questionsmedicales.fr/author/Angela%20L%20Tyner", "affiliation": { "@type": "Organization", "name": "Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: atyner@uic.edu." } }, { "@type": "Person", "name": "Eiji Kinoshita", "url": "https://questionsmedicales.fr/author/Eiji%20Kinoshita", "affiliation": { "@type": "Organization", "name": "Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan." } }, { "@type": "Person", "name": "Emiko Kinoshita-Kikuta", "url": "https://questionsmedicales.fr/author/Emiko%20Kinoshita-Kikuta", "affiliation": { "@type": "Organization", "name": "Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan." } }, { "@type": "Person", "name": "Tohru Koike", "url": "https://questionsmedicales.fr/author/Tohru%20Koike", "affiliation": { "@type": "Organization", "name": "Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan." } }, { "@type": "Person", "name": "Gongqin Sun", "url": "https://questionsmedicales.fr/author/Gongqin%20Sun", "affiliation": { "@type": "Organization", "name": "Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI, United States." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Keratoconus.", "datePublished": "2024-10-24", "url": "https://questionsmedicales.fr/article/39448666", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1038/s41572-024-00565-3" } }, { "@type": "ScholarlyArticle", "name": "Keratoconus International Consortium (KIC)- advancing keratoconus research.", "datePublished": "2023-07-27", "url": "https://questionsmedicales.fr/article/37501133", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12886-023-03087-w" } }, { "@type": "ScholarlyArticle", "name": "Biomechanical properties analysis of forme fruste keratoconus and subclinical keratoconus.", "datePublished": "2022-11-28", "url": "https://questionsmedicales.fr/article/36441226", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1007/s00417-022-05916-y" } }, { "@type": "ScholarlyArticle", "name": "Recurrent Keratoconus: Corneal Transplants for Keratoconus Develop Tomographic Ectatic Changes.", "datePublished": "2022-11-21", "url": "https://questionsmedicales.fr/article/36730373", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1097/ICO.0000000000003149" } }, { "@type": "ScholarlyArticle", "name": "Comparison of a Scheimpflug imaging with other screening indices in diagnosing keratoconus and keratoconus suspect.", "datePublished": "2024-10-05", "url": "https://questionsmedicales.fr/article/39369097", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1038/s41598-024-74497-z" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines et peptides de signalisation intracellulaire", "item": "https://questionsmedicales.fr/mesh/D047908" }, { "@type": "ListItem", "position": 5, "name": "Protein-tyrosine kinases", "item": "https://questionsmedicales.fr/mesh/D011505" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Protein-tyrosine kinases - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Protein-tyrosine kinases", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-12", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Protein-tyrosine kinases", "description": "Comment diagnostiquer une dysrégulation des kinases à tyrosine ?\nQuels marqueurs sont utilisés pour le diagnostic ?\nLes tests génétiques sont-ils utiles ?\nQuels examens d'imagerie sont recommandés ?\nLes antécédents familiaux influencent-ils le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Keratoconus#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Protein-tyrosine kinases", "description": "Quels symptômes sont liés à une suractivité des kinases ?\nLes symptômes varient-ils selon le type de kinase ?\nY a-t-il des symptômes spécifiques aux cancers ?\nLes symptômes peuvent-ils être confondus avec d'autres maladies ?\nComment les symptômes évoluent-ils dans le temps ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Keratoconus#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Protein-tyrosine kinases", "description": "Peut-on prévenir les dysfonctionnements des kinases ?\nLes dépistages réguliers sont-ils recommandés ?\nY a-t-il des vaccins préventifs ?\nLe tabagisme influence-t-il le risque ?\nLes facteurs environnementaux jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Keratoconus#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Protein-tyrosine kinases", "description": "Quels traitements ciblent les kinases à tyrosine ?\nLes traitements sont-ils personnalisés ?\nQuels effets secondaires des traitements sont courants ?\nLa radiothérapie est-elle utilisée ?\nLes traitements sont-ils efficaces à long terme ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Keratoconus#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Protein-tyrosine kinases", "description": "Quelles complications peuvent survenir avec les kinases ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles le pronostic ?\nLes complications varient-elles selon le type de cancer ?\nLes complications nécessitent-elles des traitements supplémentaires ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Keratoconus#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protein-tyrosine kinases", "description": "Quels sont les principaux facteurs de risque ?\nL'âge influence-t-il le risque de dysfonctionnement des kinases ?\nLe mode de vie joue-t-il un rôle ?\nLes infections peuvent-elles être un facteur de risque ?\nY a-t-il des facteurs génétiques impliqués ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Keratoconus#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysrégulation des kinases à tyrosine ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests sanguins et des biopsies peuvent révéler des anomalies dans l'activité des kinases." } }, { "@type": "Question", "name": "Quels marqueurs sont utilisés pour le diagnostic ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les marqueurs tumoraux comme le CA 19-9 peuvent indiquer une activité kinase anormale." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils utiles ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent identifier des mutations dans les gènes codant pour les kinases à tyrosine." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont recommandés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "L'IRM et le scanner peuvent aider à visualiser les tumeurs associées aux kinases." } }, { "@type": "Question", "name": "Les antécédents familiaux influencent-ils le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents de cancers peuvent augmenter le risque de dysrégulation des kinases." } }, { "@type": "Question", "name": "Quels symptômes sont liés à une suractivité des kinases ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, perte de poids, et douleurs osseuses peuvent indiquer une suractivité des kinases." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon le type de kinase ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes dépendent du type de kinase et de la voie de signalisation affectée." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux cancers ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme des masses palpables ou des saignements peuvent survenir." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils être confondus avec d'autres maladies ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme la fatigue peuvent être communs à plusieurs maladies." } }, { "@type": "Question", "name": "Comment les symptômes évoluent-ils dans le temps ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent s'aggraver progressivement, nécessitant une surveillance régulière." } }, { "@type": "Question", "name": "Peut-on prévenir les dysfonctionnements des kinases ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation saine et l'exercice régulier peuvent réduire le risque de cancers." } }, { "@type": "Question", "name": "Les dépistages réguliers sont-ils recommandés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dépistages peuvent aider à détecter précocement des anomalies liées aux kinases." } }, { "@type": "Question", "name": "Y a-t-il des vaccins préventifs ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des kinases." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il le risque ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme est un facteur de risque connu pour plusieurs cancers liés aux kinases." } }, { "@type": "Question", "name": "Les facteurs environnementaux jouent-ils un rôle ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des substances chimiques peut augmenter le risque de dysfonctionnement des kinases." } }, { "@type": "Question", "name": "Quels traitements ciblent les kinases à tyrosine ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les inhibiteurs de kinases, comme l'imatinib, sont utilisés pour traiter certains cancers." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des kinases." } }, { "@type": "Question", "name": "Quels effets secondaires des traitements sont courants ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, nausées et éruptions cutanées sont des effets secondaires fréquents." } }, { "@type": "Question", "name": "La radiothérapie est-elle utilisée ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la radiothérapie peut être utilisée en complément des traitements ciblés." } }, { "@type": "Question", "name": "Les traitements sont-ils efficaces à long terme ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "L'efficacité varie, mais certains patients peuvent bénéficier d'une rémission prolongée." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les kinases ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme la résistance aux traitements et la progression de la maladie peuvent survenir." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes." } }, { "@type": "Question", "name": "Comment les complications affectent-elles le pronostic ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les complications peuvent aggraver le pronostic et réduire les chances de rémission." } }, { "@type": "Question", "name": "Les complications varient-elles selon le type de cancer ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent différer selon le type de cancer et la kinase impliquée." } }, { "@type": "Question", "name": "Les complications nécessitent-elles des traitements supplémentaires ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des traitements supplémentaires peuvent être nécessaires pour gérer les complications." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux, le tabagisme et l'exposition à des produits chimiques sont des facteurs de risque." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de dysfonctionnement des kinases ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque augmente généralement avec l'âge, surtout pour certains cancers." } }, { "@type": "Question", "name": "Le mode de vie joue-t-il un rôle ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque." } }, { "@type": "Question", "name": "Les infections peuvent-elles être un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections virales, comme le virus d'Epstein-Barr, peuvent augmenter le risque." } }, { "@type": "Question", "name": "Y a-t-il des facteurs génétiques impliqués ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des mutations génétiques héréditaires peuvent prédisposer à des dysfonctionnements des kinases." } } ] } ] }
Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

Validation scientifique effectuée le 30/04/2025

Contenu vérifié selon les dernières recommandations médicales

En savoir plus sur Dr Menir

Sous-catégories

18 au total
└─

Agammaglobulinaemia tyrosine kinase

Agammaglobulinaemia Tyrosine Kinase D000077329 - D12.776.476.568.025
└─

Focal adhesion protein-tyrosine kinases

Focal Adhesion Protein-Tyrosine Kinases D051416 - D12.776.476.568.049
└─

Janus kinases

Janus Kinases D053612 - D12.776.476.568.124
└─

Mitogen-Activated Protein Kinase Kinases

Mitogen-Activated Protein Kinase Kinases D020929 - D12.776.476.568.200
└─

Syk kinase

Syk Kinase D000072377 - D12.776.476.568.650
└─

src-Family kinases

src-Family Kinases D019061 - D12.776.476.568.800
└─

ZAP-70 Protein-tyrosine kinase

ZAP-70 Protein-Tyrosine Kinase D051746 - D12.776.476.568.900
└─└─

Janus kinase 1

Janus Kinase 1 D053613 - D12.776.476.568.124.100
└─└─

Janus kinase 3

Janus Kinase 3 D053616 - D12.776.476.568.124.300
└─└─

TYK2 Kinase

TYK2 Kinase D053634 - D12.776.476.568.124.650
└─└─

MAP Kinase Kinase 1

MAP Kinase Kinase 1 D048369 - D12.776.476.568.200.100
└─└─

MAP Kinase Kinase 2

MAP Kinase Kinase 2 D048370 - D12.776.476.568.200.200
└─└─

MAP Kinase Kinase 3

MAP Kinase Kinase 3 D048371 - D12.776.476.568.200.300
└─└─

MAP Kinase Kinase 4

MAP Kinase Kinase 4 D048670 - D12.776.476.568.200.400
└─└─

MAP Kinase Kinase 5

MAP Kinase Kinase 5 D048671 - D12.776.476.568.200.500
└─└─

MAP Kinase Kinase 6

MAP Kinase Kinase 6 D048669 - D12.776.476.568.200.600
└─└─

MAP Kinase Kinase 7

MAP Kinase Kinase 7 D048688 - D12.776.476.568.200.700
└─└─

CSK tyrosine-protein kinase

CSK Tyrosine-Protein Kinase D000081247 - D12.776.476.568.800.158

Auteurs principaux

Angela L Tyner

3 publications dans cette catégorie

Affiliations :
  • Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: atyner@uic.edu.
Publications dans "Protein-tyrosine kinases" :

Eiji Kinoshita

3 publications dans cette catégorie

Affiliations :
  • Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Publications dans "Protein-tyrosine kinases" :

Emiko Kinoshita-Kikuta

3 publications dans cette catégorie

Affiliations :
  • Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Publications dans "Protein-tyrosine kinases" :

Tohru Koike

3 publications dans cette catégorie

Affiliations :
  • Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Publications dans "Protein-tyrosine kinases" :

Gongqin Sun

3 publications dans cette catégorie

Affiliations :
  • Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI, United States.
Publications dans "Protein-tyrosine kinases" :

Wanian M Alwanian

2 publications dans cette catégorie

Affiliations :
  • Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA.
Publications dans "Protein-tyrosine kinases" :

Swati Jaiswal

2 publications dans cette catégorie

Affiliations :
  • University of Massachusetts Chan Medical School, Worcester, United States. Electronic address: swati.jaiswal@umassmed.edu.
Publications dans "Protein-tyrosine kinases" :

Terry W Moody

2 publications dans cette catégorie

Affiliations :
  • Center for Cancer Training, NCI, and Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892, USA.
Publications dans "Protein-tyrosine kinases" :

Robert T Jensen

2 publications dans cette catégorie

Affiliations :
  • Center for Cancer Training, NCI, and Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892, USA.
Publications dans "Protein-tyrosine kinases" :

Cristina Lao-Peregrin

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Guoqing Xiang

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Jihye Kim

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Ipsit Srivastava

2 publications dans cette catégorie

Affiliations :
  • Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Alexandra B Fall

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Danielle M Gerhard

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Piia Kohtala

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Publications dans "Protein-tyrosine kinases" :

Daegeon Kim

2 publications dans cette catégorie

Affiliations :
  • Department of Life Sciences, Yeongnam University, Gyeongsan, Gyeongbuk 38451, South Korea.
Publications dans "Protein-tyrosine kinases" :

Minseok Song

2 publications dans cette catégorie

Affiliations :
  • Department of Life Sciences, Yeongnam University, Gyeongsan, Gyeongbuk 38451, South Korea.
Publications dans "Protein-tyrosine kinases" :

Mikel Garcia-Marcos

2 publications dans cette catégorie

Affiliations :
  • Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Publications dans "Protein-tyrosine kinases" :

Joshua Levitz

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: jtl2003@med.cornell.edu.
Publications dans "Protein-tyrosine kinases" :

Sources (697 au total)

Keratoconus International Consortium (KIC)- advancing keratoconus research.

27 Jul 2023
DOI: 10.1186/s12886-023-03087-w PMID: 37501133

The Keratoconus International Consortium (KIC) will allow better understanding of keratoconus.... Keratoconus is a disorder characterised by corneal elevation and thinning, leading to reduced vision. The current gaps in understanding of this disease will be discussed and the need for a multi-prong... KIC has been established to address the gaps in our understanding of keratoconus with the aim of collecting baseline as well as longitudinal data on several fields.... Keratoconus and control (no corneal condition) subjects from different sites globally will be recruited in the study.... KIC collects data using an online, secure database, which enables standardised data collection at member sites. Data fields collected include medical history, clinical features, quality of life and ec... There are currently 40 Australian and international clinics or hospital departments who have joined the KIC. Baseline data has so far been collected on 1130 keratoconus patients and indicates a median... The strength of this consortium is its international, collaborative design and use of a common data collection tool. Inclusion and analyses of cross-sectional and longitudinal data will help answer ma...

Humans Male Adult Female Keratoconus +5 autres

Biomechanical properties analysis of forme fruste keratoconus and subclinical keratoconus.

May 2023
DOI: 10.1007/s00417-022-05916-y PMID: 36441226

To analyze the biomechanical properties of the eye in patients with unilateral keratoconus with normal (forme fruste keratoconus [FFKC]) or abnormal topography (subclinical keratoconus [SKC]).... This study included 153 eyes of 153 participants, including 95 eyes of patients with unilateral keratoconus, and 58 eyes of 58 healthy controls. Contralateral eyes with unilateral keratoconus were div... Statistically significant differences between the FFKC and SKC groups were found in 9 of the 18 corneal biomechanical parameters analyzed using non-parametric tests. After adjusting for confounding fa... Biomechanical parameters A1-time and IR have a high diversity between FFKC and SKC, besides TBI, and may reflect more subtle changes in corneal biomechanical properties (BPs) preceding SP-A1. The BPs ...

Humans Keratoconus Corneal Topography Retrospective Studies Cornea +3 autres

Recurrent Keratoconus: Corneal Transplants for Keratoconus Develop Tomographic Ectatic Changes.

01 Jun 2023
DOI: 10.1097/ICO.0000000000003149 PMID: 36730373

The purpose of this study was to evaluate postoperative Scheimpflug imaging changes during the first 5 years after penetrating keratoplasty (PK) in patients with keratoconus (KC).... This retrospective, interventional case series includes 31 eyes of 31 patients who underwent their first PK with a history of KC. Postoperative Scheimpflug imaging was performed 3 months after the rem... The maximal keratometry (Kmax) progressed significantly between baseline (53.5 ± 6.1 D) and postoperative year 3 and year 5 [56.5 ± 6.1 diopter (D) and 58.8 ± 7.9 D, P < 0.001]. Significant changes we... Tomographic graft changes indicative of ectasia were observed within 3 to 5 years after PK in patients with KC. These changes were observed more frequently and sooner after corneal transplants than pr...

Humans Keratoconus Retrospective Studies Dilatation, Pathologic Corneal Topography +2 autres

Patient-Reported Outcomes in Keratoconus: A Save Sight Keratoconus Registry Study.

01 May 2023
DOI: 10.1097/ICO.0000000000003119 PMID: 36036705

The aim of this study was to evaluate the quality-of-life (QoL) status in keratoconus severity subgroups using the Keratoconus Outcomes Research Questionnaire (KORQ) and to determine the relationship ... A cross-sectional study was conducted using prospective, web-based Save Sight Keratoconus Registry data. Rasch analysis was conducted on the KORQ data using the Andrich Rating Scale Model. Comparative... The KORQ was completed by 542 patients with keratoconus (male, 67.7%; mean age, 31.6 years). Keratoconus severity, based on Kmax, was mild [<48 diopter (D)], moderate (48-55 D), and severe (>55 D) in ... Female sex, contact lens wear, reduced visual acuity, and higher disease severity were associated with worse AL and SY scores in keratoconus. Although the correlations between clinical and QoL scores ...

Humans Male Female Adult Keratoconus +6 autres

Revisiting the oil droplet sign in keratoconus: Utility for early keratoconus diagnosis and screening.

01 2023
DOI: 10.1111/opo.13066 PMID: 36394095

An annular dark shadow (ADS) reflex has been observed while performing direct ophthalmoscopy on subjects with keratoconus. This study describes a method that may serve as a diagnostic technique for ea... Healthy keratoconic subjects and keratoconus suspects underwent corneal tomography and a full ocular examination. Keratoconus severity was graded based on Belin ABCD criteria. An iPhone camera was con... Fifty-eight subjects participated in this study: 37 healthy controls (37 eyes) and 21 keratoconics or keratoconus suspects (37 eyes). The ADS was present in all keratoconic and keratoconus-suspect eye... The ADS may be a useful method to diagnose keratoconus and keratoconus-suspect cases and serve as a grading and follow-up method for tracking disease severity....

Humans Keratoconus Ophthalmoscopy

Keratoconus: A Biomechanical Perspective.

02 2023
DOI: 10.1080/02713683.2022.2088798 PMID: 35746888

The relevance of corneal biomechanics and the importance of including it in the clinical assessment of corneal ectasias are being increasingly recognized. The connection between corneal ultrastructure... Published articles on corneal biomechanics in the specific context of keratoconus were reviewed, based on an electronic search using PubMed, Elsevier, and Science Direct. The search terms used include... The electronic search revealed more than 500 articles, from which 80 were chosen for this article.... The structural and organizational pattern of the corneal stroma determines its mechanical properties and are responsible for the maintenance of the normal shape and function of the cornea. Changes in ...

Humans Biomechanical Phenomena Collagen Cornea Corneal Stroma +3 autres

Evaluation of Anterior and Posterior Corneal Higher Order Aberrations for the Detection of Keratoconus and Suspect Keratoconus.

02 12 2022
DOI: 10.3390/tomography8060240 PMID: 36548532

To investigate the application of anterior and posterior corneal higher-order aberrations (HOAs) in detecting keratoconus (KC) and suspect keratoconus (SKC).... A retrospective, case-control study evaluating non-ectatic (normal) eyes, SKC eyes, and KC eyes. The Sirius Scheimpfug (CSO, Italy) analyses was used to measure HOAs of the anterior and posterior corn... Two-hundred and twenty eyes were included in the analysis (normal n = 108, SKC n = 42, KC n = 70). Receiver operating characteristic (ROC) curve analysis revealed a high predictive ability for anterio... Anterior and posterior corneal higher-order aberrations can differentiate between keratoconus and normal eyes, with a high level of certainty. In suspect keratoconus disease, however, only anterior co...

Humans Keratoconus Retrospective Studies Case-Control Studies Coma +1 autres

Comparison of Keratoconus Specific to Standard IOL Formulas in Patients With Keratoconus Undergoing Cataract Surgery.

Apr 2023
DOI: 10.3928/1081597X-20230124-01 PMID: 37040215

To assess the performance of multiple intraocular lens (IOL) formulas in eyes with keratoconus.... Eyes with stable keratoconus scheduled for cataract surgery with biometry measurements on the Lenstar LS900 (Haag-Streit) were included. Prediction errors were calculated using 11 different formulas, ... Sixty-eight eyes from 44 patients were identified. In eyes with keratometric values less than 50.00 D, prediction error standard deviations ranged from 0.680 to 0.857 D. Percentages of eyes within ±0.... In keratoconic eyes, IOL formulas are less accurate than in normal eyes and result in hyperopic refractive outcomes that increase with steeper keratometric values. Using keratoconus-specific formulas ...

Humans Keratoconus Lens Implantation, Intraocular Retrospective Studies Lenses, Intraocular +1 autres