Comment diagnostiquer une hyperuricémie ?

Un test sanguin mesure le taux d'acide urique pour diagnostiquer l'hyperuricémie.

Quels tests pour la goutte ?

L'analyse du liquide synovial et des tests sanguins pour l'acide urique sont utilisés.

Quels symptômes indiquent une crise de goutte ?

Douleur intense, rougeur et gonflement d'une articulation, souvent le gros orteil.

Comment évaluer une maladie liée aux purines ?

Des tests génétiques et des analyses biochimiques peuvent être nécessaires.

Quel rôle des purines dans le diagnostic ?

Les niveaux de purines peuvent indiquer des troubles métaboliques ou des maladies rénales.

Quels sont les symptômes de l'hyperuricémie ?

Souvent asymptomatique, mais peut causer des douleurs articulaires et des calculs rénaux.

Quels signes de goutte aiguë ?

Douleur intense, rougeur, chaleur et gonflement d'une articulation, souvent nocturne.

Comment se manifeste une crise de goutte ?

Une douleur soudaine et sévère dans une articulation, souvent accompagnée d'inflammation.

Quels symptômes des troubles des purines ?

Fatigue, douleurs articulaires, et parfois des problèmes rénaux ou hépatiques.

Quels symptômes d'une maladie de Wilson ?

Accumulation de cuivre, troubles neurologiques, et symptômes hépatiques.

Comment prévenir l'hyperuricémie ?

Adopter un régime pauvre en purines et éviter l'alcool et les boissons sucrées.

Quelles habitudes pour éviter la goutte ?

Maintenir un poids santé, rester hydraté et limiter les aliments riches en purines.

Comment réduire le risque de calculs rénaux ?

Boire beaucoup d'eau et éviter les aliments riches en oxalates et purines.

Quels conseils diététiques pour les purines ?

Limiter les viandes rouges, les fruits de mer et les boissons alcoolisées.

Comment surveiller les niveaux d'acide urique ?

Des tests sanguins réguliers pour surveiller les niveaux d'acide urique et ajuster le régime.

Comment traiter l'hyperuricémie ?

Des médicaments comme les inhibiteurs de la xanthine oxydase et des changements alimentaires.

Quel traitement pour la goutte ?

Anti-inflammatoires non stéroïdiens (AINS) et colchicine pour soulager la douleur.

Comment prévenir les crises de goutte ?

Éviter les aliments riches en purines et maintenir une hydratation adéquate.

Quels médicaments pour les troubles des purines ?

Des médicaments spécifiques selon le trouble, comme les uricosuriques pour l'hyperuricémie.

Comment gérer les calculs rénaux liés aux purines ?

Hydratation, modifications alimentaires et parfois intervention chirurgicale.

Quelles complications de la goutte ?

Arthrite chronique, dépôts de tophus et risque accru de maladies cardiovasculaires.

Quels risques liés à l'hyperuricémie ?

Peut entraîner des calculs rénaux, des maladies rénales et des problèmes cardiovasculaires.

Comment l'hyperuricémie affecte-t-elle les reins ?

Peut provoquer une néphropathie urique, entraînant des lésions rénales.

Quelles complications des troubles des purines ?

Peuvent inclure des problèmes hépatiques, neurologiques et des troubles métaboliques.

Quels effets à long terme de la goutte ?

Peut entraîner des dommages articulaires permanents et des complications systémiques.

Quels facteurs de risque pour l'hyperuricémie ?

Obésité, consommation excessive d'alcool, régime riche en purines et antécédents familiaux.

Qui est à risque de goutte ?

Les hommes, les personnes obèses et celles ayant des antécédents familiaux de goutte.

Quels médicaments augmentent le risque d'hyperuricémie ?

Diurétiques, aspirine à faible dose et certains médicaments immunosuppresseurs.

Quel rôle de l'alimentation dans les purines ?

Une alimentation riche en viandes rouges, fruits de mer et boissons sucrées augmente le risque.

Comment l'âge influence-t-il l'hyperuricémie ?

Le risque d'hyperuricémie augmente avec l'âge, surtout chez les hommes après 40 ans.

Purines - Informations médicales vérifiées

Recommendation on an updated standardization of serum magnesium reference ranges.

Oct 2022

DOI: 10.1007/s00394-022-02916-w PMID: 35689124

Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnose... We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide.... Serum magnesium levels designating "hypomagnesemia" differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off val... Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To ap...

Humans Magnesium Reference Standards Reference Values

Reference Standards to Support Quality of Synthetic Peptide Therapeutics.

Jun 2023

DOI: 10.1007/s11095-023-03493-1 PMID: 36949371

Peptides are an important class of therapeutics. Their quality is evaluated using a series of analytical tests, many of which depend on well-characterized reference standards to determine identity, pu... Discuss approaches to producing peptide reference standards, including vialing, lyophilization, analytical testing and stability studies.... Case studies are used to illustrate analytical approaches to characterize reference standards, including methods for value assignment, content uniformity, and identity testing. Methods described inclu... This report describes the analytical strategy used to establish peptide reference standard and illustrates how results from multiple labs are integrated to assign a value to the final lyophilized vial... The methods and case studies described provide a benchmark for best practices in establishing the preparation, analytical testing, handling, and storage of peptide reference standards for the pharmace...

Peptides Reference Standards Chromatography, High Pressure Liquid Mass Spectrometry Magnetic Resonance Spectroscopy

Diagnosis of Genital Tuberculosis in Infertile Women by Using the Composite Reference Standard.

2022

DOI: 10.1155/2022/8078639 PMID: 36016849

Female genital tuberculosis (FGTB) can be asymptomatic or even masquerade as other gynecological conditions. Conventional methods of FGTB diagnosis include various imaging, bacteriological, molecular,...

Female Genitalia Humans Infertility, Female Reference Standards +2 autres

Development of a glucose reference material in human serum for clinical assay standardization.

10 May 2023

DOI: 10.1016/j.jpba.2023.115285 PMID: 36848767

Blood glucose is an important monosaccharide functioning as the main source of energy for the human body. The accurate measurement of blood glucose is crucial for the screening, diagnosis, and monitor... Raw serum samples were collected from residual samples after clinical testing, filtered, and repackaged under mild stirring. The homogeneity and stability of the samples were examined according to ISO... The developed RMs was homogeneous and commutable enough for clinical use. They were also stable for 24 h at 2-8 ℃ or 20-25 ℃ and for at least 4 years at - 70 ℃. The certified values were 5.20 ± 0.18 m... The developed RM could be used for the standardization of reference and clinical systems with satisfactory performance and traceable values, providing strong support for the accurate measurement of bl...

Humans Blood Glucose Glucose Reproducibility of Results Reference Standards +1 autres

The Delirium Interview as a new reference standard in studies on delirium assessment tools.

06 2023

DOI: 10.1111/jgs.18263 PMID: 36807119

The reference standard in studies on delirium assessment tools is usually based on the clinical judgment of only one delirium expert and may be concise, unstandardized, or not specified at all. This m... We tested the diagnostic accuracy of our standardized Delirium Interview by comparing delirium assessments of the reported results with live assessments. Our reference, the live assessment, was perfor... We included 98 patients (62% male, mean age 69 ± 12 years), of whom 56 (57%) intensive care units (ICUs) patients, 22 (39%) patients with a Richmond Agitation Sedation Scale (RASS) < 0 and 26 (27%) no... The Delirium Interview is a feasible reference method for large study cohorts evaluating delirium assessment tools since experts could assess delirium with high accuracy without seeing the patient at ...

Humans Male Aged Aged, 80 and over Female +5 autres

Development of an improved standard reference material for folate vitamers in human serum.

Feb 2023

DOI: 10.1007/s00216-022-04474-w PMID: 36507958

The US National Institute of Standards and Technology (NIST) developed a Standard Reference Material® (SRM®) 3949 Folate Vitamers in Frozen Human Serum to replace SRM 1955 Homocysteine and Folate in H...

Humans Folic Acid Chromatography, Liquid Tandem Mass Spectrometry Reference Standards +1 autres

A reference framework for standardization and harmonization of CT radiomics features on cadaveric sample.

20 08 2024

DOI: 10.1038/s41598-024-68158-4 PMID: 39164314

Radiomics features (RFs) serve as quantitative metrics to characterize shape, density/intensity, and texture patterns in radiological images. Despite their promise, RFs exhibit reproducibility challen...

Humans Tomography, X-Ray Computed Cadaver Image Processing, Computer-Assisted Algorithms +4 autres

MRI underestimates presence and size of knee osteophytes using CT as a reference standard.

05 2023

DOI: 10.1016/j.joca.2023.01.575 PMID: 36796577

To explore the diagnostic performance of routine magnetic resonance imaging (MRI) for the cross-sectional assessment of osteophytes (OPs) in all three knee compartments using computed tomography (CT) ... The Strontium Ranelate Efficacy in Knee Osteoarthritis (SEKOIA) trial explored the effect of 3 years of treatment with strontium ranelate in patients with primary knee OA. OPs were scored for the base... Included were 74 patients with available MRI and CT data. Mean age was 62.9 ± 7.5 years. Altogether 1,332 locations were evaluated. For the PFJ, MRI detected 141 (72%) of 197 CT-defined OPs with a w-k... MRI underestimates presence of osteophytes in all three knee compartments. CT may be helpful particularly regarding assessment of small osteophytes particularly in early disease....

Humans Middle Aged Aged Radiography Osteophyte +6 autres

Collaborative Study to Establish National Reference Standards for Anti-HIV-1 Antibody.

01 May 2023

DOI: 10.3343/alm.2023.43.3.273 PMID: 36544339

National reference standards for anti-HIV-1 antibody are needed to evaluate the performance and maintain the quality control of anti-HIV-1 antibody assays. The aim of this study was to prepare a mixed... Nineteen serum samples from different HIV patients were obtained, along with 15 units of fresh frozen plasma samples with negative anti-HIV-1 antibody results. Ten anti-HIV-1 antibody-positive candida... In the collaborative study, results of all five anti-HIV-1 antibody assays were positive for all 10 candidate standards prepared using HIV patient samples. The CV of each assay for every candidate sta... The overall results suggest that the 12 candidate standards could serve as national reference standards for anti-HIV-1 antibody....

Humans HIV Infections Reference Standards Quality Control HIV-1

Reference standards for follicular density in ovarian cortex from birth to sexual maturity.

10 2023

DOI: 10.1016/j.rbmo.2023.103287 PMID: 37603956

Are age-normalized reference values for human ovarian cortical follicular density adequate for tissue quality control in fertility preservation?... Published quantitative data on the number of follicles in samples without known ovarian pathology were converted into cortical densities to create reference values. Next, a sample cohort of 126 girls ... No difference was observed between Z-scores in samples from untreated patients (0.3 ± 3.5, n = 30) and patients treated with (0.5 ± 2.9, n = 48) and without (0.1 ± 1.3, n = 6) alkylating chemotherapy.... Z-scores allow the estimation of genetic- and treatment-related effects on follicular density in cortical tissue from young patients stored for fertility preservation. Understanding the quality of cry...

Female Humans Aged Infant Child, Preschool +9 autres

Purines : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Adénine

Allopurinol

Mercaptopurine

Purinones

Roscovitine

Citrate de sildénafil

Tioguanine

Amino-2 purine

Cytokinine

Famciclovir

Ténofovir

Hypoxanthines

Xanthines

Kinétine

Zéatine

Guanine

Hypoxanthine

Caféine

Théobromine

Théophylline

Acide urique

Xanthine

Aciclovir

8-Azaguanine

Pentoxifylline

Diphylline

Xanthine(isobutyl-3 methyl-1)

Nicotinate de xanthinol

Ganciclovir

Valaciclovir

Valganciclovir

Auteurs principaux

Sources (10000 au total)