Comment identifier une séquence régulatrice ?

L'identification se fait par des techniques comme la PCR et le séquençage.

Quels tests sont utilisés pour analyser les séquences régulatrices ?

Des tests comme l'empreinte génétique et l'analyse de l'expression génique sont utilisés.

Peut-on détecter des mutations dans ces séquences ?

Oui, des mutations peuvent être détectées par séquençage ciblé ou NGS.

Quels marqueurs sont associés aux séquences régulatrices ?

Les marqueurs épigénétiques comme la méthylation de l'ADN sont souvent associés.

Comment évaluer l'activité d'une séquence régulatrice ?

L'activité peut être évaluée par des essais de reporter génique.

Quels symptômes sont liés à des anomalies régulatrices ?

Des anomalies peuvent entraîner des maladies génétiques, des cancers ou des troubles métaboliques.

Les séquences régulatrices affectent-elles le développement ?

Oui, elles jouent un rôle crucial dans le développement embryonnaire et cellulaire.

Peut-on observer des symptômes neurologiques ?

Certaines mutations régulatrices peuvent être liées à des troubles neurologiques.

Les troubles hormonaux sont-ils liés à ces séquences ?

Oui, des séquences régulatrices peuvent influencer la régulation hormonale.

Y a-t-il des symptômes immunologiques associés ?

Des anomalies peuvent entraîner des dysfonctionnements du système immunitaire.

Comment prévenir les maladies liées aux séquences régulatrices ?

La prévention passe par le dépistage génétique et la sensibilisation aux facteurs de risque.

Les conseils génétiques sont-ils utiles ?

Oui, ils aident à évaluer le risque et à prendre des décisions éclairées.

Peut-on éviter les mutations par des choix de vie ?

Certains choix de vie, comme l'alimentation et l'exercice, peuvent réduire les risques.

Les vaccinations jouent-elles un rôle ?

Certaines vaccinations peuvent prévenir des infections qui influencent l'expression génique.

Y a-t-il des programmes de sensibilisation ?

Oui, des programmes éducatifs sensibilisent aux maladies génétiques et à leur prévention.

Quels traitements ciblent les séquences régulatrices ?

Des thérapies géniques et des médicaments ciblant des voies spécifiques sont en développement.

Peut-on corriger des mutations régulatrices ?

Des techniques comme CRISPR permettent de corriger certaines mutations.

Les traitements sont-ils personnalisés ?

Oui, la médecine personnalisée adapte les traitements selon le profil génétique.

Quels sont les défis des traitements ?

Les défis incluent la spécificité, l'efficacité et les effets secondaires potentiels.

Y a-t-il des essais cliniques en cours ?

Oui, de nombreux essais cliniques explorent des thérapies ciblant ces séquences.

Quelles complications peuvent survenir ?

Des complications incluent des cancers, des troubles métaboliques et des maladies auto-immunes.

Les complications sont-elles héréditaires ?

Certaines complications peuvent être héréditaires, liées à des mutations dans les séquences régulatrices.

Comment les complications sont-elles gérées ?

La gestion implique un suivi médical régulier et des traitements adaptés.

Y a-t-il des risques de récidive ?

Oui, certains troubles peuvent avoir un risque de récidive, nécessitant une surveillance.

Les complications affectent-elles la qualité de vie ?

Oui, elles peuvent significativement impacter la qualité de vie des patients.

Quels sont les facteurs de risque génétiques ?

Des antécédents familiaux de maladies génétiques augmentent le risque.

L'environnement influence-t-il ces séquences ?

Oui, des facteurs environnementaux comme les toxines peuvent affecter l'expression génique.

Le mode de vie joue-t-il un rôle ?

Oui, des habitudes comme le tabagisme et l'alimentation peuvent influencer le risque.

Les infections sont-elles un facteur de risque ?

Certaines infections peuvent déclencher des modifications dans les séquences régulatrices.

Y a-t-il des facteurs de risque liés à l'âge ?

Oui, le risque de maladies génétiques augmente avec l'âge.

Séquences d'acides nucléiques régulatrices - Informations médicales vérifiées

Designing and implementing a research integrity promotion plan: Recommendations for research funders.

08 2022

DOI: 10.1371/journal.pbio.3001773 PMID: 35984842

Various stakeholders in science have put research integrity high on their agenda. Among them, research funders are prominently placed to foster research integrity by requiring that the organizations a...

Humans Policy Research Design Research Personnel

Study Types in Orthopaedics Research: Is My Study Design Appropriate for the Research Question?

10 2022

DOI: 10.1016/j.arth.2022.05.028 PMID: 36162926

When performing orthopaedic clinical research, alternative study designs can be more appropriate depending on the research question, availability of data, and feasibility. The most common observationa...

Case-Control Studies Cohort Studies Cross-Sectional Studies Humans Orthopedics +1 autres

Value of implementation science and hybrid implementation research designs for nursing education research: A discussion paper.

Jul 2023

DOI: 10.1016/j.nepr.2023.103650 PMID: 37119757

Nursing education research is complex and contextualized. The evaluation and impact of educational innovations on students, educators, and educational outcomes are influenced by the complexity of envi... This paper aims to explore the value of implementation science theories, models, and frameworks and hybrid designs for interventional nursing education research and illustrate how these can be used in... A brief overview of implementation science, the various types of theories, models and frameworks and Hybrid designs are provided. Illustrative examples demonstrating the incorporation of these methodo... A brief overview of implementation and its key concepts namely context, implementation strategies, fidelity, outcomes, adaptation, and sustainability is provided. Three types of hybrid designs are dis... The implications of implementation science for nursing education research are: a) Accelerating uptake of innovations to improve educational outcomes, b) targeting systematic change in individual and o... Incorporating implementation science in nursing education research can optimize the uptake of educational innovations in practice in a sustainable manner. Nurse educators should equip themselves with ...

Humans Nursing Education Research Implementation Science Research Design Education, Nursing +1 autres

Research Methods Used in Evidence-Based Design: An Analysis of Five Years of Research Articles From the

01 2023

DOI: 10.1177/19375867221125940 PMID: 36424761

This study aims to analyze research methodologies from 157 research articles published in this journal in the last five years (2016-2020).... Health environments research is comprised of research covering many topics and from various disciplines worldwide. No systematic study exists to uncover themes in evidence-based design (EBD) research ... Case study research was used to analyze 157 articles published in the... Findings are reported on categories commonly found in empirical research articles: (i) key words, (ii) disciplines from authors, (iii) settings studied, (iv) populations studied or sampled, (v) resear... The analyses highlighted the research methods most frequently used in health environments research. Findings revealed several inconsistencies across articles on key words and the framing of research m...

Humans Research Design

The Relative Merits of Observational and Experimental Research: Four Key Principles for Optimising Observational Research Designs.

03 Nov 2022

DOI: 10.3390/nu14214649 PMID: 36364910

The main barrier to the publication of observational research is a perceived inferiority to randomised designs with regard to the reliability of their conclusions. This commentary addresses this issue...

Reproducibility of Results Research Design Sample Size Uncertainty

Study Design and Analysis in Hand Surgery Research: Tips for Success.

09 2023

DOI: 10.1016/j.jhsa.2023.04.002 PMID: 37178066

Hand surgeons are constantly faced with evaluation of new evidence to identify best practices in clinical care. However, even the most rigorous study designs have limitations due to biases, generaliza...

Humans Hand Research Design Specialties, Surgical Surgeons

Quasi-Experimental Design for Health Policy Research: A Methodology Overview.

01 03 2023

DOI: 10.1097/PRS.0000000000009974 PMID: 36730158

Health policy impacts all aspects of the authors' field. Research on this topic informs future policy direction and serves as an impactful means to advocate for their patients. The present work aims t...

Humans Health Policy Health Status Interrupted Time Series Analysis Research Design

The MoXFo initiative - study design: Considerations related to study design and methodology in exercise research for people with multiple sclerosis.

Nov 2023

DOI: 10.1177/13524585231204456 PMID: 37880962

Exercise as a subset of physical activity is a cornerstone in the management of multiple sclerosis (MS) based on its pleiotropic effects, but continued progression of the field requires better future ... This paper outlines the work of the 'Study design and methodology' group of the MoXFo (moving exercise research forward) initiative, and addresses critical aspects and future directions when defining ... The work is based on the formation of an international expert panel formed within the MoXFo initiative. We provide a structured and concise synthesis of exercise-specific MS research challenges and co... Challenges and considerations are presented using the Patient population, Intervention, Comparator, Outcomes, Timing, Setting (PICOTS) framework, thereby forming a new and specific MS exercise PICOTS ... We propose that researchers should carefully consider and align all elements of this MS exercise PICOTS framework when developing future research questions and study designs, ultimately improving the ...

Humans Multiple Sclerosis Exercise Exercise Therapy Research Design

Integrating the patients' voice in designing and delivering a research study: The Yorkshire Cancer Research funded PREHABS study's experience.

05 2023

DOI: 10.1016/j.radi.2023.04.006 PMID: 37141686

Engaging with patients when designing a clinical or research project is beneficial; feedback from the intended audience provides invaluable insight form the patients' perspective. Working with patient... Patients were included in the PREHABS study from inception to completion. The Theory of Change methodology was used to provide a framework to implement patient feedback to refine the study interventio... In total, 69 patients engaged with the PREHABS project. Two patients were recruited as co-applicants on the grant and were members on the Trial Management Group. Six patients attended the pre applicat... It is practicable and beneficial to include patients at all stages of designing and delivering a research study. Patient feedback can help refine the study interventions to allow for maximum acceptanc... Including patients in the design of radiotherapy research studies can provide invaluable insight that can support the selection and delivery of interventions that are acceptable to the patient cohort....

Male Female Humans Aged Research Design +1 autres

Still Searching for Understanding: The Importance of Diverse Research Designs, Methods, and Perspectives.

25 10 2022

DOI: 10.1044/2022_AJSLP-21-00348 PMID: 36001820

Evidence-based medicine and evidence hierarchies have been widely adopted and have strongly influenced decision making across many fields, including clinical aphasiology. However, questions remain abo... This article builds on ideas about scientific approaches and evidence originally shared by Elman (1995, 1998, 2006). This article reviews the history of evidence hierarchies and argues that improving ... Concepts from a wide variety of fields including philosophy of science, research design and methodology, and precision medicine are brought together in an attempt to focus research on the scientific u... It is hoped that by incorporating diverse research designs, methods, and perspectives, clinical aphasiologists will become better able to provide effective, personalized treatments, ensuring that each...

Humans Research Design Quality of Life Evidence-Based Medicine Aphasia

Séquences d'acides nucléiques régulatrices : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Réseaux de régulation génique

Séquences régulatrices de l'acide ribonucléique

Séquence d'encapsidation virale

Sites internes d'entrée des ribosomes

Riborégulateur

Auteurs principaux

Sources (10000 au total)