Quels sont les facteurs de risque pour les troubles du système nerveux entérique ?
Les facteurs incluent le stress, une alimentation déséquilibrée et des antécédents familiaux.
Facteurs de risqueAntécédents familiaux
#2
L'âge est-il un facteur de risque ?
Oui, le risque de troubles augmente avec l'âge en raison de changements physiologiques.
ÂgeChangements physiologiques
#3
Les maladies auto-immunes influencent-elles le système nerveux entérique ?
Oui, elles peuvent affecter la fonction intestinale et augmenter les symptômes.
Maladies auto-immunesFonction intestinale
#4
Le mode de vie sédentaire est-il un facteur de risque ?
Oui, un mode de vie sédentaire peut contribuer à des troubles de la motilité intestinale.
Mode de vie sédentaireMotilité intestinale
#5
Les infections antérieures augmentent-elles le risque ?
Oui, certaines infections gastro-intestinales peuvent prédisposer à des troubles chroniques.
Infections gastro-intestinalesTroubles chroniques
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"name": "Comment diagnostiquer une dysfonction du système nerveux entérique ?",
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"text": "Un diagnostic peut inclure des examens cliniques, des tests de motilité et des biopsies."
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer le système nerveux entérique ?",
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"text": "Les tests de transit intestinal et l'électromyographie sont couramment utilisés."
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème nerveux entérique ?",
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"@type": "Question",
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"@type": "Question",
"name": "Les habitudes de sommeil influencent-elles la santé intestinale ?",
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"@type": "Question",
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"@type": "Answer",
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"@type": "Question",
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"@type": "Answer",
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"@type": "Question",
"name": "Comment la constipation chronique affecte-t-elle la santé ?",
"position": 23,
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"@type": "Question",
"name": "Les troubles psychologiques peuvent-ils aggraver les complications ?",
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
"name": "Les infections antérieures augmentent-elles le risque ?",
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Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305 USA.
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305 USA. Electronic address: jukalts@stanford.edu.
Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. werend.boesmans@uhasselt.be.
Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium. werend.boesmans@uhasselt.be.
Laboratory for Enteric NeuroScience, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Department of Pediatric Surgery, Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA.
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-957 Olsztyn, Poland.
Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-957 Olsztyn, Poland.
Intranasal nalbuphine could be a safe, efficacious and non-invasive alternative to parenteral pain medication in infants. We aimed to assess pharmacokinetics (PK) and tolerability of intranasal and in...
Prospective open-label study including infants 1-3 months of age admitted to the emergency department, receiving nalbuphine for procedural pain management. Patients were alternately allocated to a sin...
Out of 52 study subjects receiving nalbuphine, 31 were eligible for NCA (11 intravenous, 20 intranasal). Median AUC...
This is the first study investigating intranasal administration of nalbuphine in infants suggesting an intranasal bioavailability close to 50%. Non-invasive intranasal application was well tolerated. ...
NCT03059511....
This review presents an overview of the available literature regarding intranasal corticosteroids (INCs) for the treatment of allergic rhinitis (AR). Various treatment options exist for AR including I...
Intranasal (IN) and intravenous (IV) applications of ketamine have been proven effective for the treatment of depression, but direct comparative trials or meta-analyses on whether both differ in their...
Naloxone for opioid overdose treatment can be administered by intravenous injection, intramuscular injection, or intranasal administration. Published data indicate differences in naloxone pharmacokine...
Using the model equations already derived, we performed least squares analysis on 24 sets of naloxone concentration in the blood as a function of time....
We found that intramuscular and intranasal administration can be described more accurately when considering zero-order absorption kinetics for finite time compared with classical first order absorptio...
One-compartment models work well for most cases. Two-compartment models provide better details, but have higher parameter uncertainties. The absorption duration can be determined directly from the mod...
The purpose of this study is to audit the efficacy and safety of intranasal dexmedetomidine sedation for non-invasive procedural sedation in children provided by nurses of the procedural sedation (PRO...
In this nurse-driven PROSA setting, intranasal dexmedetomidine is effective and safe for non-invasive procedural sedation in an a priori low risk group of paediatric patients....
• Procedural sedation outside the operating theatre or intensive care units is increasingly used, including sedation performed by non-anaesthesiologists or nurses. This resulted in the development of ...
• In an audit on 772 procedures, nurse-driven intranasal dexmedetomidine administration as sedation for non-invasive procedures in children within a structured framework was safe and effective. • Imag...
A physiologically based pharmacokinetic (PBPK) modeling approach for esketamine and its metabolite noresketamine after esketamine intranasal administration was developed to aid the prediction of drug-...
The intranasal PBPK (IN-PBPK) models for esketamine/noresketamine were constructed in Simcyp...
The simulated and observed (171 healthy volunteers) plasma pharmacokinetic profiles of intranasal esketamine/noresketamine showed a good match. The relative contributions of different cytochromes P450...
This PBPK model of the intranasal route adequately described the pharmacokinetics and DDI of intranasal esketamine/noresketamine with potential perpetrator and victim drugs. This work was used to supp...
Curative therapies against autoimmune diseases are lacking. Indeed, most of the currently available treatments are only targeting symptoms. We have developed a novel strategy for a therapeutic vaccine...
Intranasal administration of oxytocin is increasingly explored as a new approach to facilitate social development and reduce disability associated with a diagnosis of autism spectrum disorder (ASD). T...
A double-blind, randomized, placebo-controlled trial with parallel design explored the effects of a 4-week intranasal oxytocin administration (12 IU, twice daily) on parent-rated social responsiveness...
In the double-blind phase, both the oxytocin and placebo group displayed significant pre-to-post-improvements in social responsiveness and secondary questionnaires, but improvements were not specific ...
Future studies using larger cohorts and more explicitly controlled concurrent psychosocial trainings are warranted to further explore the preliminary moderator effects, also including understudied pop...
Four weeks of oxytocin administration did not induce treatment-specific improvements in social responsiveness in school-aged children with ASD. Future studies are warranted to further explore the clin...
Neuroblastoma is the most frequently diagnosed extracranial solid tumor in children and accounts for 7 % of all childhood malignancies and 15 % cancer mortality in children. Luteolin (LUT) is recogniz...
Intranasal midazolam can produce procedural sedation in frail older patients with dementia who are unable to tolerate necessary medical or dental procedures during domiciliary medical care. Little is ...
We recruited 12 volunteers: ASA physical status 1-2, aged 65-80 yr, and received midazolam 5 mg intravenously and 5 mg intranasally on two study days separated by a 6 day washout period. Concentration...
Time to peak effect of intranasal midazolam for BIS, MAP, and SpO...
Intranasal bioavailability was high and sedation onset was rapid, with maximum sedative effects after 32 min. We developed a pharmacokinetic/pharmacodynamic model for intranasal midazolam for older pe...
EudraCT (2019-004806-90)....
