How To Read a Network Meta-analysis.
Network meta-analysis (NMA) expands upon traditional meta-analysis by integrating three or more interventions. This allows comparing interventions using evidence from trials that have compared pairs o...
Stabilité de l'ARN : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment évaluer la stabilité de l'ARN ?
On utilise des techniques comme le Northern blot et la PCR en temps réel.
#2
Quels marqueurs indiquent une instabilité de l'ARN ?
Des niveaux élevés de dégradation et des variations dans l'expression génique peuvent indiquer une instabilité.
#3
Quels tests sont utilisés pour mesurer l'ARN ?
Les tests incluent l'électrophorèse et les analyses de séquençage.
#4
Peut-on détecter des anomalies d'ARN ?
Oui, des techniques comme le séquençage de nouvelle génération peuvent détecter des anomalies.
#5
Quel rôle joue l'ARNm dans le diagnostic ?
L'ARNm est crucial pour évaluer l'expression des gènes associés à des maladies.
Symptômes 5
#1
Quels symptômes sont liés à l'instabilité de l'ARN ?
Des symptômes variés peuvent apparaître, selon la maladie sous-jacente, comme la fatigue.
#2
L'instabilité de l'ARN peut-elle causer des maladies ?
Oui, elle est liée à des maladies comme certains cancers et des troubles neurodégénératifs.
#3
Quels signes cliniques sont observés ?
Les signes peuvent inclure des anomalies de croissance ou des troubles métaboliques.
#4
Y a-t-il des symptômes spécifiques aux maladies liées à l'ARN ?
Oui, des symptômes spécifiques peuvent inclure des troubles neurologiques ou immunitaires.
#5
Comment l'instabilité de l'ARN affecte-t-elle la santé ?
Elle peut perturber l'expression génique, entraînant des dysfonctionnements cellulaires.
Prévention 5
#1
Comment prévenir l'instabilité de l'ARN ?
Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir la stabilité de l'ARN.
#2
Y a-t-il des facteurs environnementaux à éviter ?
Oui, l'exposition à des toxines et à des radiations peut affecter la stabilité de l'ARN.
#3
L'exercice physique influence-t-il l'ARN ?
Oui, l'exercice régulier peut améliorer la santé cellulaire et la stabilité de l'ARN.
#4
Des suppléments peuvent-ils aider ?
Certains suppléments, comme les antioxydants, peuvent soutenir la stabilité de l'ARN.
#5
Comment le stress affecte-t-il l'ARN ?
Le stress chronique peut altérer la stabilité de l'ARN et affecter l'expression génique.
Traitements 5
#1
Quels traitements ciblent l'instabilité de l'ARN ?
Des thérapies géniques et des médicaments stabilisateurs d'ARN sont en développement.
#2
Peut-on utiliser des inhibiteurs pour stabiliser l'ARN ?
Oui, certains inhibiteurs peuvent réduire la dégradation de l'ARN dans les cellules.
#3
Quels médicaments sont efficaces contre l'instabilité de l'ARN ?
Des médicaments comme les antisens oligonucleotides sont utilisés pour cibler l'ARN.
#4
Comment la thérapie génique aide-t-elle ?
Elle peut corriger les défauts d'ARN, améliorant ainsi l'expression génique.
#5
Y a-t-il des traitements expérimentaux ?
Oui, des essais cliniques testent de nouvelles approches pour stabiliser l'ARN.
Complications 5
#1
Quelles complications peuvent survenir ?
Des complications incluent des maladies génétiques, des cancers et des troubles métaboliques.
#2
L'instabilité de l'ARN peut-elle entraîner des cancers ?
Oui, l'instabilité de l'ARN est souvent associée à des mécanismes tumoraux.
#3
Quels troubles métaboliques sont liés à l'ARN ?
Des troubles comme le diabète et l'obésité peuvent être influencés par l'instabilité de l'ARN.
#4
Y a-t-il des risques neurologiques ?
Oui, des maladies neurodégénératives peuvent être exacerbées par l'instabilité de l'ARN.
#5
Comment l'instabilité de l'ARN affecte-t-elle le système immunitaire ?
Elle peut altérer la réponse immunitaire, rendant l'organisme plus vulnérable aux infections.
Facteurs de risque 5
#1
Quels facteurs génétiques influencent l'ARN ?
Des mutations dans des gènes régulateurs peuvent affecter la stabilité de l'ARN.
#2
L'âge est-il un facteur de risque ?
Oui, le vieillissement peut affecter la stabilité de l'ARN et l'expression génique.
#3
Les infections virales impactent-elles l'ARN ?
Certaines infections virales peuvent perturber la stabilité de l'ARN dans les cellules hôtes.
#4
Le tabagisme influence-t-il l'ARN ?
Oui, le tabagisme peut induire des modifications qui affectent la stabilité de l'ARN.
#5
Y a-t-il des facteurs nutritionnels à considérer ?
Oui, une carence en nutriments essentiels peut compromettre la stabilité de l'ARN.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 26/04/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Hannah K Wayment-Steele
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
- Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Do Soon Kim
3 publications dans cette catégorie
Affiliations :
- Eterna Massive Open Laboratory.
- Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.
- Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
John J Nicol
3 publications dans cette catégorie
Affiliations :
- Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Roger Wellington-Oguri
3 publications dans cette catégorie
Affiliations :
- Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Andrew M Watkins
3 publications dans cette catégorie
Affiliations :
- Eterna Massive Open Laboratory.
- Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Eterna Participants
3 publications dans cette catégorie
Affiliations :
- Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Rhiju Das
3 publications dans cette catégorie
Affiliations :
- Eterna Massive Open Laboratory.
- Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
- Department of Physics, Stanford University, Stanford, CA 94305, USA.
Publications dans "Stabilité de l'ARN" :
-
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Nucleic acids research
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Nina Fasching
2 publications dans cette catégorie
Affiliations :
- IMBA-Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.
Publications dans "Stabilité de l'ARN" :
-
Transcriptome-Wide Profiling of RNA Stability.
Methods in molecular biology (Clifton, N.J.)
-
Determining mRNA Stability by Metabolic RNA Labeling and Chemical Nucleoside Conversion.
Methods in molecular biology (Clifton, N.J.)
Veronika A Herzog
2 publications dans cette catégorie
Affiliations :
- IMBA-Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.
Publications dans "Stabilité de l'ARN" :
-
Transcriptome-Wide Profiling of RNA Stability.
Methods in molecular biology (Clifton, N.J.)
-
Determining mRNA Stability by Metabolic RNA Labeling and Chemical Nucleoside Conversion.
Methods in molecular biology (Clifton, N.J.)
Stefan L Ameres
2 publications dans cette catégorie
Affiliations :
- IMBA-Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria. stefan.ameres@univie.ac.at.
- Max Perutz Labs, University of Vienna, Vienna Biocenter (VBC), Vienna, Austria. stefan.ameres@univie.ac.at.
Publications dans "Stabilité de l'ARN" :
-
Transcriptome-Wide Profiling of RNA Stability.
Methods in molecular biology (Clifton, N.J.)
-
Determining mRNA Stability by Metabolic RNA Labeling and Chemical Nucleoside Conversion.
Methods in molecular biology (Clifton, N.J.)
Besik Kankia
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
- Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
- Institute of Biophysics, Ilia State University, Tbilisi, 0162, Republic of Georgia.
Publications dans "Stabilité de l'ARN" :
-
A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability.
ChemistryOpen
-
Stability Factors of the Parallel Quadruplexes: DNA Versus RNA.
The journal of physical chemistry. B 2019-01-25
Amos J Nissley
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA.
Publications dans "Stabilité de l'ARN" :
-
Interactions between terminal ribosomal RNA helices stabilize the
RNA (New York, N.Y.) 2023-07-07
-
Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome.
Nucleic acids research
Jamie H D Cate
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA j-h-doudna-cate@berkeley.edu.
- Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA.
- Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Publications dans "Stabilité de l'ARN" :
-
Interactions between terminal ribosomal RNA helices stabilize the
RNA (New York, N.Y.) 2023-07-07
-
Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome.
Nucleic acids research
Seyed-Fakhreddin Torabi
2 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
- HHMI, Yale University School of Medicine, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
-
Structural analyses of an RNA stability element interacting with poly(A).
Proceedings of the National Academy of Sciences of the United States of America
-
RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction.
Science (New York, N.Y.) 2021-01-07
Jimin Wang
2 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
-
Structural analyses of an RNA stability element interacting with poly(A).
Proceedings of the National Academy of Sciences of the United States of America
-
RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction.
Science (New York, N.Y.) 2021-01-07
Suzanne J DeGregorio
2 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
- HHMI, Yale University School of Medicine, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
-
Structural analyses of an RNA stability element interacting with poly(A).
Proceedings of the National Academy of Sciences of the United States of America
-
RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction.
Science (New York, N.Y.) 2021-01-07
Anand T Vaidya
2 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
- HHMI, Yale University School of Medicine, New Haven, CT 06536.
- Tata Institute of Fundamental Research Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, 10 500046 Hyderabad, India.
Publications dans "Stabilité de l'ARN" :
-
Structural analyses of an RNA stability element interacting with poly(A).
Proceedings of the National Academy of Sciences of the United States of America
-
RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction.
Science (New York, N.Y.) 2021-01-07
Joan A Steitz
2 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536; wahc@stanford.edu LP26@cornell.edu joan.steitz@yale.edu.
- HHMI, Yale University School of Medicine, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
-
Structural analyses of an RNA stability element interacting with poly(A).
Proceedings of the National Academy of Sciences of the United States of America
-
RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction.
Science (New York, N.Y.) 2021-01-07
Jorge R Espinosa
2 publications dans cette catégorie
Affiliations :
- Cavendish Laboratory, Maxwell Centre, Department of Physics, University of Cambridge, Cambridge, United Kingdom. Electronic address: jr752@cam.ac.uk.
Publications dans "Stabilité de l'ARN" :
-
'RNA modulation of transport properties and stability in phase-separated condensates.
Biophysical journal 2021-11-09
-
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins.
PLoS computational biology 2022-02-02
Kathrin Leppek
2 publications dans cette catégorie
Affiliations :
- Department of Genetics, Stanford University, Stanford, CA, 94305, USA.
Publications dans "Stabilité de l'ARN" :
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Nature communications 2022-03-22
-
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
bioRxiv : the preprint server for biology 2021-03-30
Sources (10000 au total)
Methodological quality of network meta-analysis in dentistry: a meta-research.
This meta-research aimed to provide an overview of the methodological quality and risk of bias of network meta-analyses (NMA) in dentistry. Searches for NMA of randomized clinical trials with clinical...
Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis.
Non-pharmacological interventions have a myriad of available intervention options and contain multiple components. Whether specific components of non-pharmacological interventions or combinations are ... PubMed, Embase, Cochrane, CINAHL, PsycINFO, CENTRAL, Web of Science, and China's two largest databases, CNKI and Wanfang, were searched from inception to 22nd, January 2023. Randomized controlled tria... A total of 39 trials with 2959 patients were included (range of mean ages, 58.79-77.41 years). Resistance exercise might be the optimal intervention for reducing memory complaints in adults with subje... The form of physical activity performed appears to be more beneficial than cognitive interventions in reducing subjective memory complaints for adults with subjective cognitive decline, and this diffe... PROSPERO registry number. CRD42022355363....
Network meta-interpolation: Effect modification adjustment in network meta-analysis using subgroup analyses.
Effect modification (EM) may cause bias in network meta-analysis (NMA). Existing population adjustment NMA methods use individual patient data to adjust for EM but disregard available subgroup informa...
Treatments for alopecia areata: a network meta-analysis.
Alopecia areata is an autoimmune disease leading to nonscarring hair loss on the scalp or body. There are different treatments including immunosuppressants, hair growth stimulants, and contact immunot... To assess the benefits and harms of the treatments for alopecia areata (AA), alopecia totalis (AT), and alopecia universalis (AU) in children and adults.... The Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, ClinicalTrials.gov and WHO ICTRP were searched up to July 2022.... We included randomised controlled trials (RCTs) that evaluated classical immunosuppressants, biologics, small molecule inhibitors, contact immunotherapy, hair growth stimulants, and other therapies in... We used the standard procedures expected by Cochrane including assessment of risks of bias using RoB2 and the certainty of the evidence using GRADE. The primary outcomes were short-term hair regrowth ... We included 63 studies that tested 47 different treatments in 4817 randomised participants. All trials used a parallel-group design except one that used a cross-over design. The mean sample size was 7... We found that treatment with baricitinib results in an increase in short- and long-term hair regrowth compared to placebo. Although we found inconclusive results for the risk of serious adverse effect...
Bias propagation in network meta-analysis models.
Network meta-analysis combines direct and indirect evidence to compare multiple treatments. As direct evidence for one treatment contrast may be indirect evidence for other treatment contrasts, biases...
Does type of funding affect reporting in network meta-analysis? A scoping review of network meta-analyses.
Evidence has shown that private industry-sponsored randomized controlled trials (RCTs) and meta-analyses are more likely to report intervention-favourable results compared with other sources of fundin... To (a) explore the recommendation rate of industry-sponsored NMAs on their company's intervention, and (b) assess reporting in NMAs of pharmacologic interventions according to their funding type.... Design: Scoping review of published NMAs with RCTs.... We used a pre-existing NMA database including 1,144 articles from MEDLINE, EMBASE and Cochrane Database of Systematic Reviews, published between January 2013 and July 2018.... NMAs with transparent funding information and comparing pharmacologic interventions with/without placebo.... We captured whether NMAs recommended their own or another company's intervention, classified NMAs according to their primary outcome findings (i.e., statistical significance and direction of effect), ... We retrieved 658 NMAs, which reported a median of 23 items in the PRISMA-NMA checklist (interquartile range [IQR]: 21-26). NMAs were categorized as 314 publicly-sponsored (PRISMA-NMA median 24.5, IQR ... Differences in completeness of reporting and author characteristics were apparent among NMAs with different types of funding. Publicly-sponsored NMAs had the best reporting and published their finding...
Efficacy of innovative therapies in myasthenia gravis: A systematic review, meta-analysis and network meta-analysis.
Therapy for myasthenia gravis (MG) is undergoing a profound change, with new treatments being tested. These include complement inhibitors and neonatal Fc receptor (FcRn) blockers. The aim of this stud... We assessed statistical heterogeneity across trials based on the Cochrane Q test and I... We observed an overall mean Myasthenia Gravis-Activities of Daily Living scale (MG-ADL) score change of -2.17 points (95% confidence interval [CI] -2.67, -1.67; p < 0.001) as compared to placebo. No s... Anti-complement and FcRn treatments both proved to be effective in MG patients, whereas rituximab did not show a significant benefit for patients. Within the limitations of this meta-analysis, includi...
Effectiveness of aerobic exercise in the prevention and treatment of postpartum depression: Meta-analysis and network meta-analysis.
Aerobic exercise is widely recognized for improving mental health and reducing negative emotions, including anxiety. However, research on its role in preventing and treating postpartum depression (PPD... We conducted a quantitative systematic review of the study in 5 representative databases for the effect of aerobic exercise on PPD. Meta-analysis and network meta-analysis were performed with Review-M... Twenty-six studies with 2,867 participants were eventually included and the efficacy of aerobic exercise in preventing and treating postpartum depression is significant compared to standard care. (MD ... The efficacy of aerobic exercise in preventing and treating postpartum depression is significant compared to standard care, with a greater emphasis on prevention. The optimal prescribed exercise volum...
Antibiotic Prophylaxis in Reduction Mammaplasty: A Network Meta-Analysis.
Mounting evidence suggests that breast reduction surgery displays higher rates of surgical site infections (SSI) than initially presumed. Objective of this network meta-analysis is to evaluate the eff... A network meta-analysis was conducted using a predetermined protocol after searching the electronic databases MEDLINE, Scopus, the Cochrane Library and US National Institutes of Health Ongoing Trials ... A total of 10 studies was included in the analysis involving 1331 patients. All but one study controlled for major risk factors, and no differences were observed in patients' baseline characteristics.... Antibiotics mitigate the SSI rate after breast reduction. This meta-analysis provides an evidence-based strategy to optimize antibiotic administration. Further research is needed though to examine ant... This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Inst...