questionsmedicales.fr
Phénomènes chimiques
Phénomènes biochimiques
Stabilité de l'ARN
Stabilité de l'ARN : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Dégradation de l'ARN
Expression génique
Électrophorèse
Séquençage
Anomalies génétiques
Séquençage
ARN messager
Maladies génétiques
Symptômes
5
Fatigue
Maladies génétiques
Cancers
Troubles neurodégénératifs
Anomalies de croissance
Troubles métaboliques
Troubles neurologiques
Troubles immunitaires
Dysfonctionnement cellulaire
Expression génique
Prévention
5
Alimentation équilibrée
Mode de vie sain
Exercice physique
Santé cellulaire
Stress
Expression génique
Traitements
5
Thérapie génique
Médicaments stabilisateurs
Inhibiteurs
Dégradation de l'ARN
Antisens oligonucleotides
Médicaments
Thérapie génique
Expression génique
Essais cliniques
Traitements expérimentaux
Complications
5
Maladies génétiques
Cancers
Cancers
Mécanismes tumoraux
Maladies neurodégénératives
Risques neurologiques
Système immunitaire
Infections
Facteurs de risque
5
Mutations
Gènes régulateurs
Vieillissement
Expression génique
Infections virales
Stabilité de l'ARN
Tabagisme
Modifications de l'ARN
Carence nutritionnelle
Nutriments essentiels
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"name": "Comment évaluer la stabilité de l'ARN ?",
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"text": "On utilise des techniques comme le Northern blot et la PCR en temps réel."
}
},
{
"@type": "Question",
"name": "Quels marqueurs indiquent une instabilité de l'ARN ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des niveaux élevés de dégradation et des variations dans l'expression génique peuvent indiquer une instabilité."
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"@type": "Question",
"name": "Quels tests sont utilisés pour mesurer l'ARN ?",
"position": 3,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Peut-on détecter des anomalies d'ARN ?",
"position": 4,
"acceptedAnswer": {
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"text": "Oui, des techniques comme le séquençage de nouvelle génération peuvent détecter des anomalies."
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"@type": "Question",
"name": "Quel rôle joue l'ARNm dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
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"text": "L'ARNm est crucial pour évaluer l'expression des gènes associés à des maladies."
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"@type": "Question",
"name": "Quels symptômes sont liés à l'instabilité de l'ARN ?",
"position": 6,
"acceptedAnswer": {
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"text": "Des symptômes variés peuvent apparaître, selon la maladie sous-jacente, comme la fatigue."
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"@type": "Question",
"name": "L'instabilité de l'ARN peut-elle causer des maladies ?",
"position": 7,
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}
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"@type": "Question",
"name": "Quels signes cliniques sont observés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les signes peuvent inclure des anomalies de croissance ou des troubles métaboliques."
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"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques aux maladies liées à l'ARN ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes spécifiques peuvent inclure des troubles neurologiques ou immunitaires."
}
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{
"@type": "Question",
"name": "Comment l'instabilité de l'ARN affecte-t-elle la santé ?",
"position": 10,
"acceptedAnswer": {
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"text": "Elle peut perturber l'expression génique, entraînant des dysfonctionnements cellulaires."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'instabilité de l'ARN ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir la stabilité de l'ARN."
}
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{
"@type": "Question",
"name": "Y a-t-il des facteurs environnementaux à éviter ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines et à des radiations peut affecter la stabilité de l'ARN."
}
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{
"@type": "Question",
"name": "L'exercice physique influence-t-il l'ARN ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la stabilité de l'ARN."
}
},
{
"@type": "Question",
"name": "Des suppléments peuvent-ils aider ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains suppléments, comme les antioxydants, peuvent soutenir la stabilité de l'ARN."
}
},
{
"@type": "Question",
"name": "Comment le stress affecte-t-il l'ARN ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut altérer la stabilité de l'ARN et affecter l'expression génique."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent l'instabilité de l'ARN ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies géniques et des médicaments stabilisateurs d'ARN sont en développement."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des inhibiteurs pour stabiliser l'ARN ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains inhibiteurs peuvent réduire la dégradation de l'ARN dans les cellules."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont efficaces contre l'instabilité de l'ARN ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les antisens oligonucleotides sont utilisés pour cibler l'ARN."
}
},
{
"@type": "Question",
"name": "Comment la thérapie génique aide-t-elle ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut corriger les défauts d'ARN, améliorant ainsi l'expression génique."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des essais cliniques testent de nouvelles approches pour stabiliser l'ARN."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des maladies génétiques, des cancers et des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "L'instabilité de l'ARN peut-elle entraîner des cancers ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'instabilité de l'ARN est souvent associée à des mécanismes tumoraux."
}
},
{
"@type": "Question",
"name": "Quels troubles métaboliques sont liés à l'ARN ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles comme le diabète et l'obésité peuvent être influencés par l'instabilité de l'ARN."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques neurologiques ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies neurodégénératives peuvent être exacerbées par l'instabilité de l'ARN."
}
},
{
"@type": "Question",
"name": "Comment l'instabilité de l'ARN affecte-t-elle le système immunitaire ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut altérer la réponse immunitaire, rendant l'organisme plus vulnérable aux infections."
}
},
{
"@type": "Question",
"name": "Quels facteurs génétiques influencent l'ARN ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des mutations dans des gènes régulateurs peuvent affecter la stabilité de l'ARN."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la stabilité de l'ARN et l'expression génique."
}
},
{
"@type": "Question",
"name": "Les infections virales impactent-elles l'ARN ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales peuvent perturber la stabilité de l'ARN dans les cellules hôtes."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il l'ARN ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut induire des modifications qui affectent la stabilité de l'ARN."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs nutritionnels à considérer ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence en nutriments essentiels peut compromettre la stabilité de l'ARN."
}
}
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 26/04/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
3 publications dans cette catégorie
Affiliations :
Eterna Massive Open Laboratory.
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Publications dans "Stabilité de l'ARN" :
3 publications dans cette catégorie
Affiliations :
Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
3 publications dans cette catégorie
Affiliations :
Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
3 publications dans cette catégorie
Affiliations :
Eterna Massive Open Laboratory.
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Publications dans "Stabilité de l'ARN" :
3 publications dans cette catégorie
Affiliations :
Eterna Massive Open Laboratory.
Publications dans "Stabilité de l'ARN" :
3 publications dans cette catégorie
Affiliations :
Eterna Massive Open Laboratory.
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Department of Physics, Stanford University, Stanford, CA 94305, USA.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
IMBA-Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
IMBA-Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
IMBA-Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria. stefan.ameres@univie.ac.at.
Max Perutz Labs, University of Vienna, Vienna Biocenter (VBC), Vienna, Austria. stefan.ameres@univie.ac.at.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Institute of Biophysics, Ilia State University, Tbilisi, 0162, Republic of Georgia.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA j-h-doudna-cate@berkeley.edu.
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA.
Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
HHMI, Yale University School of Medicine, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
HHMI, Yale University School of Medicine, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536.
HHMI, Yale University School of Medicine, New Haven, CT 06536.
Tata Institute of Fundamental Research Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, 10 500046 Hyderabad, India.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536; wahc@stanford.edu LP26@cornell.edu joan.steitz@yale.edu.
HHMI, Yale University School of Medicine, New Haven, CT 06536.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Cavendish Laboratory, Maxwell Centre, Department of Physics, University of Cambridge, Cambridge, United Kingdom. Electronic address: jr752@cam.ac.uk.
Publications dans "Stabilité de l'ARN" :
2 publications dans cette catégorie
Affiliations :
Department of Genetics, Stanford University, Stanford, CA, 94305, USA.
Publications dans "Stabilité de l'ARN" :
The present study investigated the effect of time of day (08h00 vs. 11h00 vs. 14h00 vs. 17h00) and sex (girls vs. boys) on physical (i.e., five jump test (5JT), push-ball test and 5 m shuttle run test...
Thirty schoolchildren, equally divided in girls (n = 15; age: 9.60 ± 0.51 years) and boys (n = 15; age: 9.40 ± 0.51 years) performed the digit cancellation test, the trail making test, the 5JT, the 2 ...
Results showed that RPE at the end of the test was significantly higher at 11h00 compared to 08h00 (p = 0.02) and 14h00 (p = 0.001) and average RPE was higher at 11h00 compared to 08h00 (p = 0.001). L...
Mental flexibility, attention and jump performances were time of day dependent and push-ball test and 5mSRT performances did not change according to the time of day. Also, no clear sex effect was foun...
Chronic excessive welding exposure may be related to higher metal accumulation and structural differences in different subcortical structures. We examined how welding affected brain structures and the...
Study includes 42 welders and 31 controls without a welding history. Welding-related structural differences were assessed by volume and diffusion tensor imaging (DTI) metrics in basal ganglia, red nuc...
Compared to controls, welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) (p's < 0.036), but similar DTI or volume in other ROIs (p's > 0.117). Welders had higher b...
Welding-related higher hippocampal diffusivity metrics may be associated with higher RN R2* and lower psychomotor speed performance. Future studies are warranted to test the role of Pb exposure in the...
Alcohol-induced driving impairment can occur with any departure from a zero-blood alcohol concentration (BAC). Because intoxication is characterised by impaired judgement, drivers under the influence ...
This study examined the effects of alcohol on driving performance, four-choice reaction time (FCRT), and self-rated confidence in driving ability. It specifically focused on alcohol doses equal to com...
A randomized, double-blind, placebo-controlled design was utilised. Seventeen participants were tested in three conditions: placebo and two alcohol conditions aiming for BACs of 0.05% and 0.08%. Parti...
The high and low alcohol dose conditions resulted in a mean BAC of 0.07%, and 0.04%, respectively (n = 17). The high BAC treatment significantly increased standard deviation of lateral position (SDLP)...
The findings of this study show that driving performance and associated psychomotor functioning become significantly impaired below legally permissible driving limits in some jurisdictions. We identif...
Psychomotor skills, a cognitive and fine motor process, are an essential component to undergraduate nursing education. Currently, no national guidelines exist to guide nursing programs on the best way...
An integrative review was conducted to determine teaching and practice strategies to support psychomotor skill competence....
Four significant categories were identified and included (1) simulation; (2) technology; (3) deliberate practice; and (4) theoretical and collaborative instruction. Overall, simulation and technology ...
Additional research is needed to identify which teaching strategies best support nursing students' long-term knowledge acquisition and competency as they transition into professional practice....
Robotic surgery is a rapidly expanding field, given the wide variety of new robotic platforms emerging. Looking at the training of surgeons in robotic surgery is of extreme necessity and urgency, cons...
Patients with severe drug-resistant epilepsy (DRE) experience psychomotor disorders. Our study aimed to assess the psychomotor outcomes after vagus nerve stimulation (VNS) in this population....
We prospectively evaluated psychomotor function in 17 adult patients with severe DRE who were referred for VNS. Psychomotor functions were examined, in the preoperative period and at 18 months post-su...
At 18 months post-VNS surgery, the Piaget-head scores increased by 3 points (p = 0.008) compared to baseline. Performances were also improved for ROCF test both in copy (+2.4 points, p = 0.001) and re...
Patients with severe DRE treated with VNS experienced improved performance in terms of global psychomotor functions. Perceptual organization, visuospatial memory, laterality awareness, sustained atten...
This study examined the effects of work-related electronic communication (WREC) during non-working hours in the work from home or office setting on health....
The study recruited 98 information technology workers in a 9-day observational study. They recorded work-life events (eg, work style (working mostly from home or the office) and duration of WREC durin...
The frequency of WREC was significantly higher when working mostly from home than in the office (p<0.01). In addition, the duration of WREC was longer when working mostly from home than in the office ...
Longer WREC is associated with worse fatigue and depression and lower lapse of PVT (higher alertness) before bedtime for working mostly from the office. Workers, especially those working from the offi...
Despite being added to numerous products, little is known about cannabidiol. Drowsiness is a self-reported side effect, which could impact cognitive functioning. To determine whether cannabidiol impac...
Sustained exposure to acetaldehyde, the major metabolite of ethanol, may influence psychomotor performance even after the breath ethanol level significantly drops several hours following ethanol consu...
Alcohol hangover (AH) is associated with impaired attention and memory performance. However, whether this effect is related to reduced attentional resources remains unclear....
A dual-attention paradigm was employed to assess the effects of AH on attentional resources, delayed memory recognition, and the interaction between attentional load and AH. Mental effort and perceive...
A seminaturalistic, crossover design was used. In total, 25 healthy social drinkers aged 18-35 years, visited the laboratory following a typical night out drinking (Hangover condition) and after alcoh...
Compared with the control visit, AH was associated with reduced recognition accuracy (particularly more false negatives), higher "tracking costs" (poorer accuracy) in the dual attention condition, inc...
These findings suggest that reduced attentional resources contribute to the cognitive deficits associated with AH including impaired memory consolidation. They further suggest that while hungover, par...