Les troubles du collagène peuvent-ils entraîner des problèmes cardiovasculaires ?
Oui, certaines anomalies du collagène peuvent augmenter le risque de maladies cardiovasculaires.
Problèmes cardiovasculairesAnomalies du collagèneSanté cardiovasculaire
#3
Comment les complications affectent-elles la qualité de vie ?
Les complications peuvent réduire la mobilité et causer des douleurs, affectant la qualité de vie.
Qualité de vieMobilitéDouleurs
#4
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
ComplicationsGestionPermanence
#5
Les complications peuvent-elles survenir à tout âge ?
Oui, les complications peuvent survenir à tout âge, mais elles sont plus fréquentes chez les personnes âgées.
ÂgeComplicationsPersonnes âgées
Facteurs de risque
5
#1
Quels sont les facteurs de risque pour les troubles du collagène de type V ?
Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et des blessures répétées.
Facteurs de risqueAntécédents familiauxMaladies auto-immunes
#2
L'âge est-il un facteur de risque pour le collagène de type V ?
Oui, le vieillissement peut augmenter le risque de troubles liés au collagène.
ÂgeVieillissementCollagène
#3
Le sexe influence-t-il le risque de troubles du collagène ?
Oui, certaines conditions touchent plus fréquemment les femmes que les hommes.
SexeConditions médicalesCollagène
#4
Les habitudes de vie affectent-elles le risque de troubles du collagène ?
Oui, des habitudes comme le tabagisme et une mauvaise alimentation augmentent le risque.
Habitudes de vieTabagismeAlimentation
#5
Les maladies génétiques sont-elles un facteur de risque ?
Oui, certaines maladies génétiques peuvent prédisposer aux troubles du collagène de type V.
Maladies génétiquesPrédispositionCollagène
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie du collagène de type V ?",
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"text": "Le diagnostic repose sur des tests génétiques et des biopsies tissulaires."
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"@type": "Question",
"name": "Quels examens sont utilisés pour évaluer le collagène de type V ?",
"position": 2,
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"@type": "Question",
"name": "Les tests sanguins peuvent-ils détecter des problèmes de collagène ?",
"position": 3,
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"text": "Oui, certains marqueurs dans le sang peuvent indiquer des anomalies du collagène."
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"@type": "Question",
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"position": 4,
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"@type": "Question",
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"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en collagène de type V ?",
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
"name": "Comment les symptômes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent s'aggraver avec l'âge, affectant la mobilité et la peau."
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"@type": "Question",
"name": "Peut-on prévenir les troubles liés au collagène de type V ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir certains troubles."
}
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"@type": "Question",
"name": "L'exercice régulier aide-t-il à maintenir la santé du collagène ?",
"position": 12,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles le collagène ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en vitamine C et en acides aminés favorise la production de collagène."
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{
"@type": "Question",
"name": "Le tabagisme affecte-t-il la santé du collagène ?",
"position": 14,
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"@type": "Question",
"name": "Le stress a-t-il un impact sur le collagène ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
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}
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"@type": "Question",
"name": "Quels traitements sont disponibles pour les troubles du collagène de type V ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la physiothérapie, les médicaments anti-inflammatoires et la chirurgie."
}
},
{
"@type": "Question",
"name": "La thérapie génique est-elle une option pour le collagène de type V ?",
"position": 17,
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"@type": "Answer",
"text": "La thérapie génique est en cours d'étude pour traiter certaines anomalies du collagène."
}
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{
"@type": "Question",
"name": "Les suppléments de collagène sont-ils efficaces ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les suppléments peuvent aider à améliorer la santé des articulations, mais les preuves varient."
}
},
{
"@type": "Question",
"name": "La chirurgie est-elle nécessaire pour traiter les problèmes de collagène ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, la chirurgie peut être nécessaire pour corriger des déformations."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont utilisés pour soulager les symptômes ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anti-inflammatoires et des analgésiques sont souvent prescrits pour soulager la douleur."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des troubles du collagène de type V ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des déformations osseuses, des douleurs chroniques et des problèmes respiratoires."
}
},
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"@type": "Question",
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"name": "Les complications sont-elles réversibles ?",
"position": 24,
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"position": 25,
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"position": 26,
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"text": "Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et des blessures répétées."
}
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"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le collagène de type V ?",
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"@type": "Question",
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"position": 28,
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"@type": "Question",
"name": "Les habitudes de vie affectent-elles le risque de troubles du collagène ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme le tabagisme et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines maladies génétiques peuvent prédisposer aux troubles du collagène de type V."
}
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School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States. Electronic address: lh535@drexel.edu.
McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Veterans Administration Medical Center, Philadelphia, PA 19104, United States.
College of Food Science and Engineering, Engineering Research Center of Utilization of Tropical Polysaccharide Resources, Ministry of Education, Hainan University, Haikou 570228, China.
Mean platelet volume to platelet count ratio (MPV/PC) has been found to be an independent risk factor for mortality in various diseases, including cardiovascular disease, cancer, and hemodialysis. We ...
We conducted a retrospective cohort study at a single center and enrolled 1473 PD patients who were catheterized at our PD center from January 1, 2006, to December 31, 2013. All patients were divided ...
Our results indicated that low MPV/PC level was an independent risk factor for all-cause and CV mortality in PD patients aged less than 60 years....
To understand better those factors relevant to the increment of rise in platelet count following a platelet transfusion among thrombocytopenic neonates....
We reviewed all platelet transfusions over 6 years in our multi-neonatal intensive care unit system. For every platelet transfusion in 8 neonatal centers we recorded: (1) platelet count before and aft...
We evaluated 1797 platelet transfusions administered to 605 neonates (median one/recipient, mean 3, and range 1-52). The increment was not associated with gestational age at birth, postnatal age at tr...
The magnitude of post-transfusion rise was unaffected by most variables we studied. However, the increment was lower in neonates with consumptive thrombocytopenia, after pathogen reduction, with longe...
Platelets play a role in hemostasis, thrombosis, and vascular integrity. They also play a major role in the development of inflammation and the activation of immune responses. They have phagocytic act...
Platelets are primarily recognized for their role in hemostasis, but also regulate immune responses by interacting with leukocytes. Their highly sensitive nature enables platelets to rapidly respond t...
Many studies have reported the association between platelets and preeclampsia. However, sample sizes were small, and their findings were inconsistent. We conducted a systematic review and meta-analysi...
A systematic literature search was performed using Medline, Embase, ScienceDirect, Web of Science, Cochrane Library, NICHD-DASH, LILACS, and Scopus from inception to April 22, 2022....
Observational studies comparing platelet count between women with preeclampsia and normotensive pregnant women were included....
The mean differences with 95% confidence interval in platelet count were calculated. Heterogeneity was assessed using I...
A total of 56 studies comprising 4892 preeclamptic and 9947 normotensive pregnant women were included. Meta-analysis showed that platelet count was significantly lower in women with preeclampsia than ...
This meta-analysis confirmed that platelet count was significantly lower in preeclamptic women, irrespective of severity and presence or absence of associated complications, even before the onset of p...
Megakaryocytes (MKs), a kind of functional hematopoietic stem cell, form platelets to maintain platelet balance through cell differentiation and maturation. In recent years, the incidence of blood dis...
Platelet transfusion is commonly performed in infants to correct severe thrombocytopenia or prevent bleeding. Exploring the associations of platelet transfusion, platelet count (PC), and mean platelet...
To evaluate the associations of platelet transfusion, PC, and MPV with IVH and in-hospital mortality and to explore whether platelet transfusion-associated IVH and mortality risks vary with PC and MPV...
This retrospective cohort study included preterm infants who were transferred to the neonatal intensive care unit on their day of birth and received ventilation during their hospital stay. The study w...
Platelet transfusion, PC, and MPV....
Any grade IVH, severe IVH (grade 3 or 4), and in-hospital mortality....
Among the 1221 preterm infants (731 [59.9%] male; median [IQR] gestational age, 31.0 [29.0-33.0] weeks), 94 (7.7%) received 166 platelet transfusions. After adjustment for potential confounders, plate...
In preterm infants, platelet transfusion, PC, and MPV were associated with mortality, and PC was also associated with any grade IVH and severe IVH. The findings suggest that a lower platelet transfusi...
The familial chylomicronemia syndrome (FCS) is an ultra rare disease caused by lipoprotein lipase (LPL) deficiency associated with potentially lethal acute pancreatitis risk. Thrombocytopenia (platele...
To evaluate post-prandial fluctuations in the platelet count (PLC) and functional defects of hemostasis in FCS....
PLC, functional defects in hemostasis and hematologic variables were measured up-to 5 h after a meal in 6 homozygotes for FCS causing gene variants (HoLPL), 6 heterozygotes for LPL loss-of-function va...
Hourly post-prandial PLC was significantly lower in HoLPL than in controls (P < 0.009). Compared to the other groups, the PLC tended to decrease rapidly (in the first hour) post-meal in HoLPL (P = 0.0...
The PLC decreases post-prandially in FCS (HoLPL), is not associated with changes in functional defects of hemostasis and correlates with the NLR, a marker of acute pancreatitis severity....
This study aimed to evaluate the role of platelet count (PLT) in the prognosis of patients with acute respiratory distress syndrome (ARDS)....
The data were extracted from the Medical Information Mart for Intensive Care database (version 2.2). Patients diagnosed with ARDS according to criteria from Berlin Definition and had the platelet coun...
Overall, the final analysis included 3,207 eligible participants with ARDS. According to the Kaplan-Meier curves for 28-day mortality of PLT, PLT ≤ 100 × 10...
PLT appeared to be an independent predictor of mortality in critically ill patients with ARDS....
Linezolid (LZD) is one of the antibiotics used to treat methicillin-resistant Staphylococcus aureus. In Japan, the dose of LZD is not generally adjusted by renal function or therapeutic drug monitorin...
Fifty-five critically ill patients with existing thrombocytopenia (platelet count < 100 ×103 /μL) who received LZD for five days or more during the period from January 2011 to October 2018 were includ...
Mean (± standard error) platelet count prior to initiation of LZD was 47 ± 4 ×103 /uL, which increased significantly to 86 ± 13 ×103 /uL on day 15 (p<0.01). Median [interquartile range] duration of LZ...
Thrombocytopenia in critically ill patients in the ICU did not worsen after initiation of LZD therapy, and may be considered for the treatment of MRSA in this setting....
