Comment diagnostiquer une dysfonction mitochondriale ?

Un diagnostic peut inclure des tests génétiques, des biopsies musculaires et des analyses biochimiques.

Quels tests sanguins sont utilisés pour évaluer les protéines mitochondriales ?

Des tests de lactate, pyruvate et des enzymes spécifiques peuvent être effectués.

Quels symptômes indiquent une maladie mitochondriale ?

Fatigue, faiblesse musculaire, troubles neurologiques et problèmes cardiaques peuvent indiquer une maladie.

Les tests génétiques sont-ils fiables pour les maladies mitochondriales ?

Oui, les tests génétiques peuvent identifier des mutations spécifiques liées aux maladies mitochondriales.

Quel rôle joue l'imagerie dans le diagnostic mitochondrial ?

L'imagerie par résonance magnétique (IRM) peut aider à visualiser des anomalies cérébrales.

Quels sont les symptômes courants des maladies mitochondriales ?

Les symptômes incluent fatigue, douleurs musculaires, troubles de la vision et épilepsie.

Les troubles cognitifs sont-ils liés aux protéines mitochondriales ?

Oui, des troubles cognitifs peuvent survenir en raison de dysfonctionnements mitochondriaux.

Comment la myopathie mitochondriale se manifeste-t-elle ?

Elle se manifeste par une faiblesse musculaire, des crampes et une intolérance à l'exercice.

Les troubles cardiaques sont-ils fréquents dans les maladies mitochondriales ?

Oui, des cardiomyopathies peuvent se développer en raison de dysfonctionnements mitochondriaux.

Les symptômes varient-ils selon l'âge d'apparition ?

Oui, les symptômes peuvent varier considérablement selon l'âge d'apparition de la maladie.

Peut-on prévenir les maladies mitochondriales ?

Certaines maladies génétiques ne peuvent pas être prévenues, mais un mode de vie sain aide.

L'exercice physique peut-il réduire les risques ?

Oui, l'exercice régulier peut améliorer la santé mitochondriale et réduire les risques.

Les antioxydants jouent-ils un rôle préventif ?

Oui, les antioxydants peuvent protéger les mitochondries des dommages oxydatifs.

Une alimentation équilibrée est-elle importante ?

Oui, une alimentation riche en nutriments soutient la santé mitochondriale.

Les dépistages précoces sont-ils recommandés ?

Oui, le dépistage précoce peut aider à identifier les risques et à intervenir rapidement.

Quels traitements sont disponibles pour les maladies mitochondriales ?

Les traitements incluent des suppléments, des thérapies symptomatiques et des approches nutritionnelles.

Les coenzymes Q10 sont-elles bénéfiques ?

Oui, le coenzyme Q10 peut améliorer la fonction mitochondriale et réduire les symptômes.

La thérapie génique est-elle une option pour ces maladies ?

La thérapie génique est en recherche, mais elle pourrait offrir des solutions futures.

Les régimes alimentaires peuvent-ils aider ?

Oui, des régimes spécifiques peuvent soutenir la fonction mitochondriale et améliorer les symptômes.

Les traitements varient-ils selon le type de maladie mitochondriale ?

Oui, les traitements doivent être adaptés au type spécifique de maladie mitochondriale.

Quelles complications peuvent survenir avec les maladies mitochondriales ?

Les complications incluent des troubles neurologiques, cardiaques et endocriniens.

Les maladies mitochondriales peuvent-elles affecter la fertilité ?

Oui, certaines maladies mitochondriales peuvent entraîner des problèmes de fertilité.

Les complications peuvent-elles être gérées ?

Certaines complications peuvent être gérées avec des traitements symptomatiques appropriés.

Les maladies mitochondriales augmentent-elles le risque de cancer ?

Certaines études suggèrent un lien entre dysfonction mitochondriale et risque accru de cancer.

Les complications cardiovasculaires sont-elles fréquentes ?

Oui, les maladies mitochondriales peuvent entraîner des cardiomyopathies et d'autres complications.

Quels sont les facteurs de risque pour les maladies mitochondriales ?

Les facteurs incluent des antécédents familiaux, des mutations génétiques et des expositions environnementales.

L'âge est-il un facteur de risque ?

Oui, certaines maladies mitochondriales se manifestent plus fréquemment avec l'âge.

Les facteurs environnementaux influencent-ils les maladies mitochondriales ?

Oui, l'exposition à des toxines peut augmenter le risque de dysfonction mitochondriale.

Le stress oxydatif est-il un facteur de risque ?

Oui, le stress oxydatif peut endommager les mitochondries et contribuer à des maladies.

Les habitudes alimentaires peuvent-elles influencer le risque ?

Oui, une alimentation pauvre en nutriments peut augmenter le risque de dysfonction mitochondriale.

Protéines mitochondriales - Informations médicales vérifiées

Endometrial ablation techniques in treating menorrhagia.

Jun 2023

DOI: 10.23736/S2724-606X.22.05101-6 PMID: 35912462

Menorrhagia is a frequent gynecological problem that is clinically described as excessive blood loss of 80 mL per menstrual cycle. It has the potential to lower their quality of life and to induce ane...

Female Humans Endometrial Ablation Techniques Menorrhagia Quality of Life +2 autres

Endometrial cancer after endometrial ablation: a systematic review.

05 12 2022

DOI: 10.1136/ijgc-2022-003866 PMID: 36375895

To investigate whether a previously performed endometrial ablation is associated with the development and diagnosis of endometrial cancer.... First, a systematic review was performed of the articles reporting the incidence of endometrial cancer in patients treated with endometrial ablation. Second, a systematic review was performed to ident... Based on 11 included studies, the incidence of endometrial cancer in a population of 29 102 patients with a prior endometrial ablation ranged from 0.0% to 1.6%.A total of 38 cases of endometrial cance... Previous endometrial ablation is not associated with the development of endometrial cancer. Diagnostic work-up is not impeded by previous endometrial ablation. In addition, endometrial cancers after e...

Female Humans Endometrial Ablation Techniques Menorrhagia Endometrial Neoplasms +2 autres

Evaluation of Radiofrequency Endometrial Ablation: A 17-year Canadian Experience.

Nov 2023

DOI: 10.1016/j.jmig.2023.07.002 PMID: 37451502

The purpose of this study was to better elucidate radiofrequency endometrial ablation (REA) durability by assessing the probability of failure as defined by need for postablation hysterectomy. Age at ... A retrospective cohort study was conducted using patient data between April 1, 2002, and March 31, 2019. REAF cases were identified using operative procedure codes. Cox proportional hazard regression ... This study was conducted at Regina General Hospital in Regina, Saskatchewan, Canada.... Patient population included those who were 21 years of age or older, were premenopausal, and had a history of heavy menstrual bleeding at the time of REA.... The intervention under investigation was REA.... The overall probability of postablation hysterectomy was 22.6%. The probabilities of postablation hysterectomy were 36.1% for women younger than 30 years (n = 128), 28% for women 30 to 34.9 years old ... Postablation hysterectomy is more likely to occur in women younger than 40 years. REA can be considered in women aged 30 to 39.9 years old, who have no known REAF risk factors. Women younger than 40 y...

Pregnancy Humans Female Young Adult Adult +5 autres

First and second-generation endometrial ablation devices: A network meta-analysis.

28 May 2024

DOI: 10.1136/bmjopen-2022-065966 PMID: 38806429

First-generation and second-generation endometrial ablation (EA) techniques, along with medical treatment and invasive surgery, are considered successful lines of management for abnormal uterine bleed... Systematic review and network meta-analysis using a frequentist network.... We searched Medline (Ovid), PubMed, ClinicalTrials.gov, Cochrane CENTRAL, Web of Science, EBSCO and Scopus for all published studies up to 1 March 2021 using relevant keywords.... We included all randomised controlled trials (RCTs) that compared premenopausal women with AUB receiving the intervention of second-generation EA techniques.... 49 high-quality RCTs with 8038 women were included. We extracted and pooled the data and then analysed to estimate the network meta-analysis models within a frequentist framework. We used the random-e... Our network meta-analysis showed many varying results according to specific outcomes. The uterine balloon ablation had significantly higher amenorrhoea rates than other techniques in both short (hydro... Most second-generation EA systems were superior to first-generation systems, and statistical superiority between devices depended on which characteristic was measured (secondary amenorrhoea rate, trea...

Humans Female Endometrial Ablation Techniques Network Meta-Analysis Uterine Hemorrhage +1 autres

Risk of Hysterectomy After Endometrial Ablation: A Systematic Review and Meta-analysis.

01 Jul 2023

DOI: 10.1097/AOG.0000000000005223 PMID: 37290114

To assess the risk of hysterectomy after nonresectoscopic endometrial ablation in patients with heavy menstrual bleeding.... The EMBASE, MEDLINE, ClinicalTrials.gov and Cochrane databases were searched for eligible articles from inception until June 13, 2022. We used combinations of search terms for endometrial ablation and... Articles included in the review described the incidence of hysterectomy at a specific point in time after ablation with a minimum follow-up duration of 12 months.... The literature search yielded a total of 3,022 hits. A total of 53 studies met our inclusion and exclusion criteria, including six retrospective studies, 24 randomized controlled trials, and 23 prospe... The risk of hysterectomy after endometrial ablation seems to increase from 4.3% after 1 year to 12.4% after 5 years. Clinicians can use the results of this review to counsel patients about the 12% ris... PROSPERO, CRD42020156281....

Female Humans Endometrial Ablation Techniques Prospective Studies Retrospective Studies +2 autres

Endometrial ablation plus levonorgestrel releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding: study protocol of a multicentre randomised controlled trial; MIRA2 trial.

27 06 2022

DOI: 10.1186/s12905-022-01843-6 PMID: 35761328

It is estimated that between 12 to 25% of women who undergo an endometrial ablation for heavy menstrual bleeding (HMB) are dissatisfied after two years because of recurrent menstrual bleeding and/or c... We perform a multicentre randomised controlled trial in 35 hospitals in the Netherlands. Women with heavy menstrual bleeding, who opt for treatment with endometrial ablation and without contraindicati... The results of this study will help clinicians inform women with HMB who opt for treatment with endometrial ablation about whether concomitant use of the LNG-IUS is beneficial for reducing the need fo...

Contraceptive Agents, Female Endometrial Ablation Techniques Female Humans Intrauterine Devices, Medicated +6 autres

Long-term incidence of endometrial cancer after endometrial resection and ablation: A population based Swedish gynecologic cancer group (SweGCG) study.

08 2022

DOI: 10.1111/aogs.14385 PMID: 35624547

Minimally invasive methods to reduce menorrhagia were introduced in the 1980s and 1990s. Transcervical endometrial resection (TCRE) and endometrial ablation (EA) are two of the most frequently used me... The Swedish National Patient Registry and National Quality Registry for Gynecological Surgery were used for identification of women who had TCRE or EA performed between 1997-2017. The cohort was follo... In total, 17 296 women (mean age 45.1 years) underwent TCRE (n = 8626) or EA (n = 8670). Excluded were 3121 who had a hysterectomy for benign causes during follow up. During a median follow-up time of... There was a significant reduction of EC after EA, suggesting a protective effect, whereas endometrial resection showed an incidence within the expected rate....

Endometrial Ablation Techniques Endometrial Neoplasms Endometrium Female Humans +5 autres

The ISTH-BAT score and outcomes after endometrial ablation in women with heavy menstrual bleeding.

Nov 2023

DOI: 10.1111/hae.14872 PMID: 37758646

The International Society on Thrombosis and Haemostasis bleeding assessment tool (ISTH-BAT), is used during the diagnostic workup of bleeding disorders. Data on ISTH-BAT scores in women with heavy men... To investigate the postsurgical incidence of amenorrhea, dysmenorrhea, quality of life, re-intervention after EA, and ISTH-BAT score.... This study included women who have undergone EA because of HMB. During a follow-up of 2 to 5 years, ISTH-BAT, pictorial blood assessment chart (PBAC), and Short Form-36 survey (SF-36) were administere... Seventy-one women were included of whom 77% (n = 55) had an ISTH-BAT score < 6, versus 23% (n = 16) ISTH-BAT score ≥6 (mean age 46.3 versus 42.3, p = 0.004). In the ISTH-BAT ≥6 group versus < 6 group,... An ISTH-BAT score ≥6 may be related to a lower amenorrhea incidence and higher dysmenorrhea rate after EA....

Female Humans Middle Aged Menorrhagia Endometrial Ablation Techniques +6 autres

Hysteroscopic Endometrial Ablation: From Indications to Instrumentation and Techniques-A Call to Action.

17 Jan 2023

DOI: 10.3390/diagnostics13030339 PMID: 36766443

The development of minimally invasive techniques has led to the creation of innovative alternatives in cases where traditional methods are not applicable. In modern gynecology, hysteroscopy has become...

Effectiveness and Safety of Ultrasound-guided Percutaneous Microwave Ablation for a Single Uterine Fibroid Greater than 300 cm

04 2023

DOI: 10.1016/j.jmig.2022.12.013 PMID: 36563871

To evaluate the effectiveness and safety of ultrasound-guided percutaneous microwave ablation (MWA) for a single uterine fibroid greater than 300 cm... Retrospective observational study.... China-Japan Union Hospital of Jilin University, China.... Thirty-seven patients each with a single fibroid greater than 300 cm... Ultrasound-guided percutaneous MWA.... All patients were followed up for 12 months postoperatively to assess the postoperative lesion volume reduction rate, degree of symptomatic relief, improvements in quality of life, and occurrence of a... Ultrasound-guided percutaneous MWA has good clinical efficacy and high safety in the treatment of a single uterine fibroid greater than 300 cm...

Female Humans High-Intensity Focused Ultrasound Ablation Leiomyoma Microwaves +6 autres

Protéines mitochondriales : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Aldehyde dehydrogenase, mitochondrial

Mitochondrial creatine kinase

DNA Polymerase gamma

Ferrochelatase

Protéines de transport de la membrane mitochondriale

Protéine trifonctionnelle mitochondriale

Nucleoside diphosphate kinase D

Peroxiredoxin III

Prohibitines

Sirtuine-3

Mitochondrial ADP, ATP Translocases

Pore de transition de perméabilité mitochondriale

Protéines du complexe d'import des protéines précurseurs mitochondriales

Mitochondrial Proton-Translocating ATPases

Protéines de découplage mitochondrial

Canal anionique-1 voltage-dépendant

Canal anionique-2 voltage-dépendant

Sous-unité alpha de la protéine trifonctionnelle mitochondriale

Sous-unité bêta de la protéine trifonctionnelle mitochondriale

Translocateur-1 de nucléotides adényliques

Translocateur-2 de nucléotides adényliques

Translocateur-3 de nucléotides adényliques

Protéine-1 de découplage

Protéine-2 de découplage

Protéine-3 de découplage

Auteurs principaux

Sources (10000 au total)