Correspondence of Child Age and Gender Distribution in Child Sexual Exploitation Material and Other Child Content With Age and Gender of Child Sexual Assault Victims.
Accessing child sexual exploitation material (CSEM;...
Complexe protéique adaptateur, sous-unités bêta : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une anomalie des sous-unités bêta ?
Des tests génétiques et des analyses protéomiques peuvent être utilisés.
#2
Quels tests sont utilisés pour évaluer les complexes protéiques ?
L'électrophorèse et la spectrométrie de masse sont couramment utilisés.
#3
Les biopsies sont-elles nécessaires pour le diagnostic ?
Pas toujours, mais elles peuvent être utiles pour des analyses spécifiques.
#4
Quels marqueurs biologiques sont associés aux sous-unités bêta ?
Des biomarqueurs spécifiques peuvent indiquer des dysfonctionnements.
#5
Peut-on utiliser l'imagerie pour diagnostiquer des anomalies ?
L'imagerie moléculaire peut aider à visualiser les complexes protéiques.
Symptômes 5
#1
Quels symptômes sont liés aux dysfonctionnements des sous-unités bêta ?
Des troubles métaboliques et des anomalies de signalisation peuvent survenir.
#2
Les symptômes sont-ils toujours visibles ?
Non, certains dysfonctionnements peuvent être asymptomatiques.
#3
Y a-t-il des symptômes spécifiques à surveiller ?
Des anomalies dans le développement cellulaire peuvent être observées.
#4
Les symptômes varient-ils selon les individus ?
Oui, la présentation clinique peut varier d'une personne à l'autre.
#5
Les symptômes peuvent-ils s'aggraver avec le temps ?
Oui, certains dysfonctionnements peuvent progresser et s'aggraver.
Prévention 5
#1
Peut-on prévenir les anomalies des sous-unités bêta ?
Certaines anomalies génétiques peuvent être évitées par des conseils génétiques.
#2
Y a-t-il des mesures préventives recommandées ?
Un mode de vie sain et des dépistages réguliers sont conseillés.
#3
Les vaccinations peuvent-elles aider ?
Certaines vaccinations peuvent prévenir des infections qui aggravent les symptômes.
#4
L'éducation sur la santé est-elle importante ?
Oui, elle aide à sensibiliser aux risques et aux signes précoces.
#5
Les tests génétiques peuvent-ils prévenir des complications ?
Oui, ils permettent d'identifier les risques et de prendre des mesures préventives.
Traitements 5
#1
Quels traitements sont disponibles pour les anomalies des sous-unités bêta ?
Les traitements ciblent souvent les symptômes et peuvent inclure des thérapies géniques.
#2
Les médicaments peuvent-ils aider à corriger les dysfonctionnements ?
Oui, certains médicaments peuvent moduler la signalisation cellulaire.
#3
La thérapie génique est-elle une option viable ?
Oui, elle est prometteuse pour traiter certaines anomalies génétiques.
#4
Des interventions chirurgicales sont-elles nécessaires ?
Rarement, sauf en cas de complications graves associées.
#5
Les traitements sont-ils personnalisés ?
Oui, les traitements peuvent être adaptés en fonction des besoins individuels.
Complications 5
#1
Quelles complications peuvent survenir avec des anomalies des sous-unités bêta ?
Des troubles métaboliques graves et des maladies associées peuvent se développer.
#2
Les complications sont-elles réversibles ?
Certaines peuvent être gérées, mais d'autres peuvent être irréversibles.
#3
Y a-t-il des risques de cancer associés ?
Oui, des anomalies dans la signalisation cellulaire peuvent augmenter le risque de cancer.
#4
Les complications affectent-elles la qualité de vie ?
Oui, elles peuvent avoir un impact significatif sur la qualité de vie des patients.
#5
Des complications neurologiques sont-elles possibles ?
Oui, des dysfonctionnements peuvent entraîner des troubles neurologiques.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour les anomalies des sous-unités bêta ?
Des antécédents familiaux et des mutations génétiques sont des facteurs clés.
#2
L'environnement joue-t-il un rôle dans ces anomalies ?
Oui, des facteurs environnementaux peuvent influencer l'expression génétique.
#3
Le mode de vie peut-il affecter le risque ?
Oui, un mode de vie malsain peut augmenter le risque de dysfonctionnements.
#4
Les infections peuvent-elles être un facteur de risque ?
Certaines infections virales peuvent déclencher des anomalies dans la signalisation.
#5
Les facteurs hormonaux influencent-ils ces anomalies ?
Oui, des déséquilibres hormonaux peuvent affecter la fonction des complexes protéiques.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 15/04/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Mustafa Sahin
4 publications dans cette catégorie
Affiliations :
- Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
- Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Human molecular genetics
-
Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.
Neurology 2021-09-20
-
Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.
Movement disorders : official journal of the Movement Disorder Society 2023-07-22
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Darius Ebrahimi-Fakhari
4 publications dans cette catégorie
Affiliations :
- Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Human molecular genetics
-
Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.
Neurology 2021-09-20
-
Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.
Movement disorders : official journal of the Movement Disorder Society 2023-07-22
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Raffaella De Pace
3 publications dans cette catégorie
Affiliations :
- Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits.
Molecular biology of the cell 2022-08-17
-
The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia.
bioRxiv : the preprint server for biology 2023-12-22
-
The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia.
Progress in neurobiology 2024-01-26
Juan S Bonifacino
3 publications dans cette catégorie
Affiliations :
- Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits.
Molecular biology of the cell 2022-08-17
-
The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia.
bioRxiv : the preprint server for biology 2023-12-22
-
The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia.
Progress in neurobiology 2024-01-26
Jennifer Hirst
3 publications dans cette catégorie
Affiliations :
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complexes and disease at a glance.
Journal of cell science 2019-10-21
-
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Human molecular genetics
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Mara C Duncan
3 publications dans cette catégorie
Affiliations :
- Cell and Developmental Biology Department, University of Michigan, Ann Arbor, MI, USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Exomer complex regulates protein traffic at the TGN through differential interactions with cargos and clathrin adaptor complexes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
-
Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast.
The Journal of biological chemistry 2018-12-06
-
RUSHing back: Kinetic analysis of adaptor protein complex-1 (AP-1)-mediated retrograde traffic.
The Journal of cell biology 2024-06-24
Angelica D'Amore
3 publications dans cette catégorie
Affiliations :
- Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
- Molecular Medicine, IRCCS Fondazione Stella Maris, 56018 Pisa, Italy.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Human molecular genetics
-
Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.
Neurology 2021-09-20
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Filippo M Santorelli
3 publications dans cette catégorie
Affiliations :
- Molecular Medicine, IRCCS Fondazione Stella Maris, 56018 Pisa, Italy.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Human molecular genetics
-
Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.
Movement disorders : official journal of the Movement Disorder Society 2023-07-22
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Marvin Ziegler
3 publications dans cette catégorie
Affiliations :
- From the Department of Neurology (D.E.-F., J.E.A., M.Z., G.G., C.J., A.D., A.S., M.S.), and Division of Neuroradiology, Department of Radiology (S.P.P., E.Y.), The Manton Center for Orphan Disease Research (D.E.-F., R.C.Y., S.K.A.), Rosamund Stone Zander Translational Neuroscience Center (M.S.), and Division of Genetics and Genomics (D.E.-F., R.C.Y., S.K.A.), Boston Children's Hospital, Harvard Medical School, MA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.
Neurology 2021-09-20
-
Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.
Movement disorders : official journal of the Movement Disorder Society 2023-07-22
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Afshin Saffari
3 publications dans cette catégorie
Affiliations :
- From the Department of Neurology (D.E.-F., J.E.A., M.Z., G.G., C.J., A.D., A.S., M.S.), and Division of Neuroradiology, Department of Radiology (S.P.P., E.Y.), The Manton Center for Orphan Disease Research (D.E.-F., R.C.Y., S.K.A.), Rosamund Stone Zander Translational Neuroscience Center (M.S.), and Division of Genetics and Genomics (D.E.-F., R.C.Y., S.K.A.), Boston Children's Hospital, Harvard Medical School, MA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.
Neurology 2021-09-20
-
Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.
Movement disorders : official journal of the Movement Disorder Society 2023-07-22
-
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia.
Brain : a journal of neurology
Alexandra K Davies
2 publications dans cette catégorie
Affiliations :
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complexes and disease at a glance.
Journal of cell science 2019-10-21
-
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Human molecular genetics
Margot Meyers
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA.
- Novartis-Berkeley Translational Chemical Biology Institute.
- Innovative Genomics Institute, Berkeley, CA 94720 USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1.
bioRxiv : the preprint server for biology 2023-08-12
-
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
ACS chemical biology 2024-01-08
Sabine Cismoski
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA.
- Novartis-Berkeley Translational Chemical Biology Institute.
- Innovative Genomics Institute, Berkeley, CA 94720 USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1.
bioRxiv : the preprint server for biology 2023-08-12
-
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
ACS chemical biology 2024-01-08
Anoohya Panidapu
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA.
- Novartis-Berkeley Translational Chemical Biology Institute.
- Innovative Genomics Institute, Berkeley, CA 94720 USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1.
bioRxiv : the preprint server for biology 2023-08-12
-
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
ACS chemical biology 2024-01-08
Barbara Chie-Leon
2 publications dans cette catégorie
Affiliations :
- Novartis-Berkeley Translational Chemical Biology Institute.
- Novartis Institutes for BioMedical Research, Emeryville, CA 94608 USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1.
bioRxiv : the preprint server for biology 2023-08-12
-
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
ACS chemical biology 2024-01-08
Daniel K Nomura
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA.
- Novartis-Berkeley Translational Chemical Biology Institute.
- Innovative Genomics Institute, Berkeley, CA 94720 USA.
- Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 USA.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1.
bioRxiv : the preprint server for biology 2023-08-12
-
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
ACS chemical biology 2024-01-08
Lin Wang
2 publications dans cette catégorie
Affiliations :
- The Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine, Center for Medical Genetics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
The endoplasmic reticulum membrane protein complex subunit
Genes & diseases 2023-05-23
-
Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration.
Medical science monitor : international medical journal of experimental and clinical research 2020-01-31
Patrick J Mulholland
2 publications dans cette catégorie
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
bioRxiv : the preprint server for biology 2023-08-17
-
Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
Molecular psychiatry 2023-09-07
Stefano Berto
2 publications dans cette catégorie
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
bioRxiv : the preprint server for biology 2023-08-17
-
Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
Molecular psychiatry 2023-09-07
Phillip A Wilmarth
2 publications dans cette catégorie
Publications dans "Complexe protéique adaptateur, sous-unités bêta" :
-
Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
bioRxiv : the preprint server for biology 2023-08-17
-
Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
Molecular psychiatry 2023-09-07
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Trajectories of child growth, child development, and home child-rearing quality during the Covid pandemic in rural Nepal.
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Caregivers' Perceptions of Child Trauma Symptomatology, Stress, and Child Abuse Disclosures.
Caregivers consider child abuse disclosures stressful life events, but research has not investigated whether this stress affects caregiver ratings of child trauma symptomatology. Secondary data from a...
Child protection training for professionals to improve reporting of child abuse and neglect.
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Primary adrenal insufficiency is relatively common in children, but primary presentation with acute shock/adrenal crisis is rare. Congenital adrenal hyperplasia (CAH) is the most common cause in child... We admitted a schoolgirl with a history of nausea and morning sickness for the previous three weeks. Shortly after admission she was somnolent, tachycardic (148 beats per minute) and pale. After initi... Acute adrenal crisis is a rare primary presentation of adrenal insufficiency, especially in the paediatric population. It is an important differential diagnosis of shock and has high morbidity and mor...