Mitochondrial Factors in the Cell Nucleus.
The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene transfer from the original proteobacterium to the host nucleus. Thus, mitochondr...
Signaux de polyadénylation : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment identifier les signaux de polyadénylation ?
L'analyse bioinformatique et les séquençages d'ARN permettent d'identifier ces signaux.
#2
Quels tests sont utilisés pour étudier la polyadénylation ?
Les tests RT-PCR et Northern blot sont couramment utilisés pour étudier la polyadénylation.
#3
Les signaux de polyadénylation sont-ils visibles sur des gels ?
Oui, les produits de polyadénylation peuvent être visualisés sur des gels d'agarose après électrophorèse.
#4
Peut-on détecter des anomalies dans la polyadénylation ?
Des anomalies peuvent être détectées par des variations dans la taille des ARNm sur des gels.
#5
Quels marqueurs indiquent une polyadénylation efficace ?
La présence d'une queue poly-A et la stabilité de l'ARNm sont des marqueurs d'efficacité.
Symptômes 5
#1
Quels symptômes sont liés à des défauts de polyadénylation ?
Des défauts peuvent entraîner une instabilité de l'ARNm, affectant la synthèse protéique.
#2
Les maladies génétiques sont-elles liées à la polyadénylation ?
Oui, certaines maladies génétiques peuvent résulter de mutations affectant les signaux de polyadénylation.
#3
Comment la polyadénylation affecte-t-elle le cancer ?
Des altérations dans la polyadénylation peuvent conduire à une expression aberrante de gènes oncogènes.
#4
Y a-t-il des symptômes associés à des ARNm instables ?
Oui, des ARNm instables peuvent entraîner des troubles métaboliques et des anomalies cellulaires.
#5
Les infections virales affectent-elles la polyadénylation ?
Certaines infections virales peuvent perturber les signaux de polyadénylation, affectant l'hôte.
Prévention 5
#1
Peut-on prévenir les anomalies de polyadénylation ?
La prévention passe par une bonne santé génétique et des dépistages précoces des maladies.
#2
Quel rôle joue l'alimentation dans la polyadénylation ?
Une alimentation équilibrée peut influencer positivement la régulation des gènes liés à la polyadénylation.
#3
Les facteurs environnementaux affectent-ils la polyadénylation ?
Oui, des facteurs comme les toxines peuvent perturber les mécanismes de polyadénylation.
#4
Comment le stress oxydatif influence-t-il la polyadénylation ?
Le stress oxydatif peut endommager l'ADN et affecter les signaux de polyadénylation.
#5
Les vaccinations influencent-elles la polyadénylation ?
Certaines recherches suggèrent que les vaccinations peuvent moduler l'expression des gènes liés.
Traitements 5
#1
Existe-t-il des traitements pour les anomalies de polyadénylation ?
Actuellement, il n'existe pas de traitements spécifiques, mais des thérapies géniques sont explorées.
#2
Comment les médicaments peuvent-ils influencer la polyadénylation ?
Certains médicaments peuvent moduler l'expression des gènes impliqués dans la polyadénylation.
#3
Les thérapies ciblées peuvent-elles aider ?
Oui, les thérapies ciblées peuvent potentiellement corriger les défauts de polyadénylation.
#4
Y a-t-il des approches expérimentales en cours ?
Des recherches sur des inhibiteurs spécifiques de la polyadénylation sont en cours dans des modèles précliniques.
#5
Les suppléments nutritionnels peuvent-ils aider ?
Certaines études suggèrent que des nutriments spécifiques pourraient soutenir la polyadénylation.
Complications 5
#1
Quelles complications peuvent survenir avec des défauts de polyadénylation ?
Des complications incluent des troubles métaboliques, des cancers et des maladies neurodégénératives.
#2
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles selon la gravité.
#3
Comment les complications affectent-elles la qualité de vie ?
Les complications peuvent réduire la qualité de vie en limitant les capacités fonctionnelles.
#4
Y a-t-il des risques de complications à long terme ?
Oui, des risques de complications à long terme existent, notamment des cancers et des maladies chroniques.
#5
Les complications peuvent-elles être prévenues ?
Certaines complications peuvent être prévenues par un suivi médical régulier et des interventions précoces.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour les anomalies de polyadénylation ?
Les facteurs incluent des mutations génétiques, des expositions environnementales et des infections.
#2
L'âge est-il un facteur de risque ?
Oui, l'âge avancé peut augmenter le risque de mutations affectant la polyadénylation.
#3
Les habitudes de vie influencent-elles la polyadénylation ?
Des habitudes comme le tabagisme et l'alcoolisme peuvent affecter les mécanismes de polyadénylation.
#4
Les maladies chroniques augmentent-elles les risques ?
Oui, certaines maladies chroniques peuvent prédisposer à des anomalies de polyadénylation.
#5
Les facteurs génétiques jouent-ils un rôle ?
Oui, des antécédents familiaux de maladies peuvent augmenter le risque d'anomalies de polyadénylation.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/03/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Xiaohui Wu
6 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen, China.
- National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
- Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal.
International journal of molecular sciences 2019-02-22
-
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq.
Genomics, proteomics & bioinformatics 2022-09-24
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
Guoli Ji
6 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen, China.
- National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
- Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal.
International journal of molecular sciences 2019-02-22
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
-
scDAPA: detection and visualization of dynamic alternative polyadenylation from single cell RNA-seq data.
Bioinformatics (Oxford, England)
Congting Ye
5 publications dans cette catégorie
Affiliations :
- National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
- Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq.
Genomics, proteomics & bioinformatics 2022-09-24
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
-
scDAPA: detection and visualization of dynamic alternative polyadenylation from single cell RNA-seq data.
Bioinformatics (Oxford, England)
Bin Tian
5 publications dans cette catégorie
Affiliations :
- Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Publications dans "Signaux de polyadénylation" :
-
The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts.
Nucleic acids research
-
SCAPTURE: a deep learning-embedded pipeline that captures polyadenylation information from 3' tag-based RNA-seq of single cells.
Genome biology 2021-08-10
-
ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs.
The EMBO journal 2019-03-11
-
MAAPER: model-based analysis of alternative polyadenylation using 3' end-linked reads.
Genome biology 2021-08-10
-
Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation.
Scientific reports 2024-07-23
Mihaela Zavolan
5 publications dans cette catégorie
Affiliations :
- Computational and Systems Biology, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
- Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Nucleic acids research
-
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.
Nucleic acids research
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
-
MAPP unravels frequent co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer.
Nature communications 2024-05-15
Wenbin Ye
4 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen 361005, China.
- Xiamen Research Institute of National Center of Healthcare Big Data, Xiamen 361005, China.
Publications dans "Signaux de polyadénylation" :
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq.
Genomics, proteomics & bioinformatics 2022-09-24
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
-
TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders.
bioRxiv : the preprint server for biology 2024-01-22
Christina J Herrmann
4 publications dans cette catégorie
Affiliations :
- Computational and Systems Biology, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
- Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Nucleic acids research
-
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.
Nucleic acids research
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Alexander Kanitz
4 publications dans cette catégorie
Affiliations :
- Computational and Systems Biology, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
- Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Nucleic acids research
-
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.
Nucleic acids research
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Matthew R Gazzara
3 publications dans cette catégorie
Affiliations :
- Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Publications dans "Signaux de polyadénylation" :
-
RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.
Cell reports
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Sven Danckwardt
3 publications dans cette catégorie
Affiliations :
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
- German Center for Cardiovascular Research (DZHK), Rhine-Main, Germany.
Publications dans "Signaux de polyadénylation" :
-
Emerging Roles of RNA 3'-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders.
Biomolecules 2020-06-17
-
TRENDseq-A highly multiplexed high throughput RNA 3' end sequencing for mapping alternative polyadenylation.
Methods in enzymology 2021-05-26
-
The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen.
Frontiers in genetics 2022-04-28
Hongjuan Fu
3 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
scAPAmod: Profiling Alternative Polyadenylation Modalities in Single Cells from Single-Cell RNA-Seq Data.
International journal of molecular sciences 2022-07-23
Dinghai Zheng
3 publications dans cette catégorie
Affiliations :
- Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Publications dans "Signaux de polyadénylation" :
-
The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts.
Nucleic acids research
-
ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs.
The EMBO journal 2019-03-11
-
MAAPER: model-based analysis of alternative polyadenylation using 3' end-linked reads.
Genome biology 2021-08-10
Kevin Struhl
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Publications dans "Signaux de polyadénylation" :
-
How is polyadenylation restricted to 3'-untranslated regions?
Yeast (Chichester, England) 2023-12-02
-
3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.
Molecular and cellular biology 2022-08-16
-
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate.
Proceedings of the National Academy of Sciences of the United States of America 2024-05-15
Gregor Rot
3 publications dans cette catégorie
Affiliations :
- Institute of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
- Swiss Institute of Bioinformatics, Amphipôle, Quartier UNIL-Sorge, 1015 Lausanne, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage.
International journal of molecular sciences 2023-04-01
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Joseph V Geisberg
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Publications dans "Signaux de polyadénylation" :
-
3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.
Molecular and cellular biology 2022-08-16
-
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate.
Proceedings of the National Academy of Sciences of the United States of America 2024-05-15
-
Location of polyadenylation sites within 3' untranslated regions is linked to biological function in yeast.
Genetics 2024-10-09
Zarmik Moqtaderi
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Publications dans "Signaux de polyadénylation" :
-
3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.
Molecular and cellular biology 2022-08-16
-
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate.
Proceedings of the National Academy of Sciences of the United States of America 2024-05-15
-
Location of polyadenylation sites within 3' untranslated regions is linked to biological function in yeast.
Genetics 2024-10-09
Wei Li
3 publications dans cette catégorie
Affiliations :
- Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, United States. Electronic address: wei.li@uci.edu.
Publications dans "Signaux de polyadénylation" :
-
Computational analysis of alternative polyadenylation from standard RNA-seq and single-cell RNA-seq data.
Methods in enzymology 2021-04-23
-
3'aQTL-atlas: an atlas of 3'UTR alternative polyadenylation quantitative trait loci across human normal tissues.
Nucleic acids research
-
TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders.
bioRxiv : the preprint server for biology 2024-01-22
Leonard Schärfen
3 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics & Biochemistry, Yale University, New Haven CT, USA.
Publications dans "Signaux de polyadénylation" :
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
-
Identification of Alternative Polyadenylation in
Frontiers in genetics 2022-01-28
Ran Elkon
2 publications dans cette catégorie
Affiliations :
- Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Publications dans "Signaux de polyadénylation" :
Stefano Spada
2 publications dans cette catégorie
Affiliations :
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Publications dans "Signaux de polyadénylation" :
-
Emerging Roles of RNA 3'-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders.
Biomolecules 2020-06-17
-
The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen.
Frontiers in genetics 2022-04-28
Sources (10000 au total)
The Material Properties of the Cell Nucleus: A Matter of Scale.
Chromatin regulatory processes physically take place in the environment of the cell nucleus, which is filled with the chromosomes and a plethora of smaller biomolecules. The nucleus contains macromole...
Comparison of cell type distribution between single-cell and single-nucleus RNA sequencing: enrichment of adherent cell types in single-nucleus RNA sequencing.
Single-cell ribonucleic acid (RNA) sequencing (scRNA-seq) is an effective technique for estimating the cellular composition and transcriptional profiles of individual cells from fresh tissue. Single-n...
Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice.
Cell mechanics play an important role in tumor metastasis, malignant transformation of cells, and radiosensitivity. During these processes, studying the mechanical properties of the cells is often cha...
ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus.
The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers an...
Nucleus size and its effect on nucleosome stability in living cells.
DNA architectural proteins play a major role in organization of chromosomal DNA in living cells by packaging it into chromatin, whose spatial conformation is determined by an intricate interplay betwe...
Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.
The HIV-1 genome encodes a small number of proteins with structural, enzymatic, regulatory, and accessory functions. These viral proteins interact with a number of host factors to promote the early an...
Live Cell Imaging Reveals HBV Capsid Translocation from the Nucleus To the Cytoplasm Enabled by Cell Division.
Hepatitis B virus (HBV) capsid assembly is traditionally thought to occur predominantly in the cytoplasm, where the virus gains access to the virion egress pathway. To better define sites of HBV capsi...
Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast.
Cells actively position their nuclei based on their activity. In fission yeast, microtubule-dependent nuclear centering is critical for symmetrical cell division. After spindle disassembly at the end ...
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In addition to the evidence mentioned earlier, several studies have shown that programm... THP-1 cells were mainly treated with Erastin and IMP-366. The changes of ferroptosis and necroptosis levels were detected by CCK-8, western blot, quantitative real-time PCR, and electron microscopy. F... The addition of the myristoylation inhibitor IMP-366 to erastin-treated acute monocytic leukemia cell line THP-1 cell not only resulted in greater susceptibility to ferroptosis characterized by lipid ... We demonstrated that inhibition of myristoylation by IMP-366 is capable of switching ferroptosis and ferroptosis-dependent necroptosis in THP-1 cells. In these findings, FSP1-mediated ferroptosis and ...