Targeted lateral pelvic lymph node excision in the setting of total neoadjuvant therapy for rectal cancer.
Targeted lateral pelvic node dissection in the era of total neoadjuvant therapy....
Signaux de polyadénylation : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment identifier les signaux de polyadénylation ?
L'analyse bioinformatique et les séquençages d'ARN permettent d'identifier ces signaux.
#2
Quels tests sont utilisés pour étudier la polyadénylation ?
Les tests RT-PCR et Northern blot sont couramment utilisés pour étudier la polyadénylation.
#3
Les signaux de polyadénylation sont-ils visibles sur des gels ?
Oui, les produits de polyadénylation peuvent être visualisés sur des gels d'agarose après électrophorèse.
#4
Peut-on détecter des anomalies dans la polyadénylation ?
Des anomalies peuvent être détectées par des variations dans la taille des ARNm sur des gels.
#5
Quels marqueurs indiquent une polyadénylation efficace ?
La présence d'une queue poly-A et la stabilité de l'ARNm sont des marqueurs d'efficacité.
Symptômes 5
#1
Quels symptômes sont liés à des défauts de polyadénylation ?
Des défauts peuvent entraîner une instabilité de l'ARNm, affectant la synthèse protéique.
#2
Les maladies génétiques sont-elles liées à la polyadénylation ?
Oui, certaines maladies génétiques peuvent résulter de mutations affectant les signaux de polyadénylation.
#3
Comment la polyadénylation affecte-t-elle le cancer ?
Des altérations dans la polyadénylation peuvent conduire à une expression aberrante de gènes oncogènes.
#4
Y a-t-il des symptômes associés à des ARNm instables ?
Oui, des ARNm instables peuvent entraîner des troubles métaboliques et des anomalies cellulaires.
#5
Les infections virales affectent-elles la polyadénylation ?
Certaines infections virales peuvent perturber les signaux de polyadénylation, affectant l'hôte.
Prévention 5
#1
Peut-on prévenir les anomalies de polyadénylation ?
La prévention passe par une bonne santé génétique et des dépistages précoces des maladies.
#2
Quel rôle joue l'alimentation dans la polyadénylation ?
Une alimentation équilibrée peut influencer positivement la régulation des gènes liés à la polyadénylation.
#3
Les facteurs environnementaux affectent-ils la polyadénylation ?
Oui, des facteurs comme les toxines peuvent perturber les mécanismes de polyadénylation.
#4
Comment le stress oxydatif influence-t-il la polyadénylation ?
Le stress oxydatif peut endommager l'ADN et affecter les signaux de polyadénylation.
#5
Les vaccinations influencent-elles la polyadénylation ?
Certaines recherches suggèrent que les vaccinations peuvent moduler l'expression des gènes liés.
Traitements 5
#1
Existe-t-il des traitements pour les anomalies de polyadénylation ?
Actuellement, il n'existe pas de traitements spécifiques, mais des thérapies géniques sont explorées.
#2
Comment les médicaments peuvent-ils influencer la polyadénylation ?
Certains médicaments peuvent moduler l'expression des gènes impliqués dans la polyadénylation.
#3
Les thérapies ciblées peuvent-elles aider ?
Oui, les thérapies ciblées peuvent potentiellement corriger les défauts de polyadénylation.
#4
Y a-t-il des approches expérimentales en cours ?
Des recherches sur des inhibiteurs spécifiques de la polyadénylation sont en cours dans des modèles précliniques.
#5
Les suppléments nutritionnels peuvent-ils aider ?
Certaines études suggèrent que des nutriments spécifiques pourraient soutenir la polyadénylation.
Complications 5
#1
Quelles complications peuvent survenir avec des défauts de polyadénylation ?
Des complications incluent des troubles métaboliques, des cancers et des maladies neurodégénératives.
#2
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles selon la gravité.
#3
Comment les complications affectent-elles la qualité de vie ?
Les complications peuvent réduire la qualité de vie en limitant les capacités fonctionnelles.
#4
Y a-t-il des risques de complications à long terme ?
Oui, des risques de complications à long terme existent, notamment des cancers et des maladies chroniques.
#5
Les complications peuvent-elles être prévenues ?
Certaines complications peuvent être prévenues par un suivi médical régulier et des interventions précoces.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour les anomalies de polyadénylation ?
Les facteurs incluent des mutations génétiques, des expositions environnementales et des infections.
#2
L'âge est-il un facteur de risque ?
Oui, l'âge avancé peut augmenter le risque de mutations affectant la polyadénylation.
#3
Les habitudes de vie influencent-elles la polyadénylation ?
Des habitudes comme le tabagisme et l'alcoolisme peuvent affecter les mécanismes de polyadénylation.
#4
Les maladies chroniques augmentent-elles les risques ?
Oui, certaines maladies chroniques peuvent prédisposer à des anomalies de polyadénylation.
#5
Les facteurs génétiques jouent-ils un rôle ?
Oui, des antécédents familiaux de maladies peuvent augmenter le risque d'anomalies de polyadénylation.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/03/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Xiaohui Wu
6 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen, China.
- National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
- Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal.
International journal of molecular sciences 2019-02-22
-
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq.
Genomics, proteomics & bioinformatics 2022-09-24
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
Guoli Ji
6 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen, China.
- National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
- Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal.
International journal of molecular sciences 2019-02-22
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
-
scDAPA: detection and visualization of dynamic alternative polyadenylation from single cell RNA-seq data.
Bioinformatics (Oxford, England)
Congting Ye
5 publications dans cette catégorie
Affiliations :
- National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
- Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq.
Genomics, proteomics & bioinformatics 2022-09-24
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
-
scDAPA: detection and visualization of dynamic alternative polyadenylation from single cell RNA-seq data.
Bioinformatics (Oxford, England)
Bin Tian
5 publications dans cette catégorie
Affiliations :
- Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Publications dans "Signaux de polyadénylation" :
-
The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts.
Nucleic acids research
-
SCAPTURE: a deep learning-embedded pipeline that captures polyadenylation information from 3' tag-based RNA-seq of single cells.
Genome biology 2021-08-10
-
ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs.
The EMBO journal 2019-03-11
-
MAAPER: model-based analysis of alternative polyadenylation using 3' end-linked reads.
Genome biology 2021-08-10
-
Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation.
Scientific reports 2024-07-23
Mihaela Zavolan
5 publications dans cette catégorie
Affiliations :
- Computational and Systems Biology, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
- Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Nucleic acids research
-
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.
Nucleic acids research
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
-
MAPP unravels frequent co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer.
Nature communications 2024-05-15
Wenbin Ye
4 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen 361005, China.
- Xiamen Research Institute of National Center of Healthcare Big Data, Xiamen 361005, China.
Publications dans "Signaux de polyadénylation" :
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq.
Genomics, proteomics & bioinformatics 2022-09-24
-
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.
Briefings in bioinformatics
-
TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders.
bioRxiv : the preprint server for biology 2024-01-22
Christina J Herrmann
4 publications dans cette catégorie
Affiliations :
- Computational and Systems Biology, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
- Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Nucleic acids research
-
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.
Nucleic acids research
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Alexander Kanitz
4 publications dans cette catégorie
Affiliations :
- Computational and Systems Biology, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
- Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Nucleic acids research
-
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing.
Nucleic acids research
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Matthew R Gazzara
3 publications dans cette catégorie
Affiliations :
- Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Publications dans "Signaux de polyadénylation" :
-
RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.
Cell reports
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Sven Danckwardt
3 publications dans cette catégorie
Affiliations :
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
- German Center for Cardiovascular Research (DZHK), Rhine-Main, Germany.
Publications dans "Signaux de polyadénylation" :
-
Emerging Roles of RNA 3'-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders.
Biomolecules 2020-06-17
-
TRENDseq-A highly multiplexed high throughput RNA 3' end sequencing for mapping alternative polyadenylation.
Methods in enzymology 2021-05-26
-
The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen.
Frontiers in genetics 2022-04-28
Hongjuan Fu
3 publications dans cette catégorie
Affiliations :
- Department of Automation, Xiamen University, Xiamen, China.
Publications dans "Signaux de polyadénylation" :
-
Modeling of Genome-Wide Polyadenylation Signals in
Frontiers in genetics 2019-07-03
-
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data.
Briefings in bioinformatics
-
scAPAmod: Profiling Alternative Polyadenylation Modalities in Single Cells from Single-Cell RNA-Seq Data.
International journal of molecular sciences 2022-07-23
Dinghai Zheng
3 publications dans cette catégorie
Affiliations :
- Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Publications dans "Signaux de polyadénylation" :
-
The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts.
Nucleic acids research
-
ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs.
The EMBO journal 2019-03-11
-
MAAPER: model-based analysis of alternative polyadenylation using 3' end-linked reads.
Genome biology 2021-08-10
Kevin Struhl
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Publications dans "Signaux de polyadénylation" :
-
How is polyadenylation restricted to 3'-untranslated regions?
Yeast (Chichester, England) 2023-12-02
-
3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.
Molecular and cellular biology 2022-08-16
-
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate.
Proceedings of the National Academy of Sciences of the United States of America 2024-05-15
Gregor Rot
3 publications dans cette catégorie
Affiliations :
- Institute of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
- Swiss Institute of Bioinformatics, Amphipôle, Quartier UNIL-Sorge, 1015 Lausanne, Switzerland.
Publications dans "Signaux de polyadénylation" :
-
Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage.
International journal of molecular sciences 2023-04-01
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
Joseph V Geisberg
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Publications dans "Signaux de polyadénylation" :
-
3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.
Molecular and cellular biology 2022-08-16
-
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate.
Proceedings of the National Academy of Sciences of the United States of America 2024-05-15
-
Location of polyadenylation sites within 3' untranslated regions is linked to biological function in yeast.
Genetics 2024-10-09
Zarmik Moqtaderi
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Publications dans "Signaux de polyadénylation" :
-
3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.
Molecular and cellular biology 2022-08-16
-
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate.
Proceedings of the National Academy of Sciences of the United States of America 2024-05-15
-
Location of polyadenylation sites within 3' untranslated regions is linked to biological function in yeast.
Genetics 2024-10-09
Wei Li
3 publications dans cette catégorie
Affiliations :
- Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, United States. Electronic address: wei.li@uci.edu.
Publications dans "Signaux de polyadénylation" :
-
Computational analysis of alternative polyadenylation from standard RNA-seq and single-cell RNA-seq data.
Methods in enzymology 2021-04-23
-
3'aQTL-atlas: an atlas of 3'UTR alternative polyadenylation quantitative trait loci across human normal tissues.
Nucleic acids research
-
TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders.
bioRxiv : the preprint server for biology 2024-01-22
Leonard Schärfen
3 publications dans cette catégorie
Affiliations :
- Department of Molecular Biophysics & Biochemistry, Yale University, New Haven CT, USA.
Publications dans "Signaux de polyadénylation" :
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
bioRxiv : the preprint server for biology 2023-06-26
-
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
RNA (New York, N.Y.) 2023-10-10
-
Identification of Alternative Polyadenylation in
Frontiers in genetics 2022-01-28
Ran Elkon
2 publications dans cette catégorie
Affiliations :
- Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Publications dans "Signaux de polyadénylation" :
Stefano Spada
2 publications dans cette catégorie
Affiliations :
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
- Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Publications dans "Signaux de polyadénylation" :
-
Emerging Roles of RNA 3'-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders.
Biomolecules 2020-06-17
-
The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen.
Frontiers in genetics 2022-04-28
Sources (7990 au total)
Prone position thoracoscopic-assisted total mesoesophageal excision: initial experiences and benefits of lymph node dissection.
Total mesoesophageal excision (TME) is a promising procedure. Prone position thoracoscopic-assisted TME might be a good choice, even without robust evidence yet. Therefore, it is necessary to explore ... We retrospectively analyzed the short-term outcomes regarding intraoperative unplanned events, postoperative complications, and lymphadenectomy in 61 patients who underwent prone position thoracoscopi... Of these sixty-one patients, there were 10, 24 and 27 cases of tumor in the upper, middle, and lower thoracic, respectively. Although there were five cases of unplanned events during surgery, no conve... The prone position thoracoscopic-assisted TME is a safe procedure that is more conducive to thoracic lymph node dissection, especially for middle and lower mediastinum....
Efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.
To study the efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.... Patients with more than 200 mL of lymph drained per day until postoperative day 3 after pelvic lymph node excision were enrolled. Of the 75 patients, 36 were managed by conservative methods without th... The total and mean daily amount of lymph produced per patient was significantly lower in the octreotide-treated group than in the untreated group. The duration of drain placement was shorter in the oc... The injection of octreotide is effective to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies....
Lymph node recurrence after right colon resection for cancer: evidence for the utilisation of complete mesocolic excision.
Complete mesocolic excision (CME) of colon cancer is a resection performed along embryological planes to include the completely intact mesentery surrounding the tumour with a high central vascular lig...
Subcostal lymph nodes: An unusual sentinel lymph node basin in cutaneous melanoma.
Lymphatic drainage from subcostal nodes, along the costal groove, have not previously been characterized as sites for melanoma drainage and metastasis. This study reports a series of patients with sub... Patients who presented to our institution between 2005 and 2020 with documented cutaneous melanoma and sentinel lymph node biopsy of a subcostal node (sentinel = S), or metastases to subcostal nodes l... Six patients had subcostal sentinel nodes (SNs). Primary sites included the posterior trunk and lateral chest wall. Subcostal nodes were found under ribs 10-12. Subcostal SNs had at least one dimensio... Melanoma can metastasize to subcostal lymph nodes and be found at the time of SN biopsy or identified at recurrence. These small nodes are fed by lymphatic channels that run in the neurovascular bundl...
Lymph Node Positivity of Axillary Reverse Mapping Lymph Nodes at the Time of Axillary Lymph Node Dissection: Two-Site Prospective Trial.
Axillary reverse mapping (ARM) was introduced in 2007 to identify and selectively preserve upper-extremity lymphatics during axillary lymph node surgery to decrease the risk of lymphedema. The patient... Patients undergoing ALND with or without immediate lymphatic reconstruction (ILR) were enrolled in a prospective trial at two institutional sites between April 2018 and Decemeber 2022. This report ana... The inclusion criteria were met by 139 patients, who made up the study population (133 with breast cancer and 6 with other disease). Of the breast cancer patients, 99.2% were female, 35.3% (47/133) we... In the contemporary patient population undergoing ALND, the positivity rate of the ARM LN was relatively high, suggesting that leaving ARM LNs in patients undergoing ALND may not be oncologically safe...
Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography.
This study evaluated the efficacy of lymphosonography in the identification of sentinel lymph nodes (SLNs) in post neoadjuvant chemotherapy patients with breast cancer scheduled to undergo surgical ex... Seventy-nine subjects scheduled for breast cancer surgery with SLN excision completed this IRB-approved study, out of which 18 (23%) underwent neoadjuvant chemotherapy before surgery. Subjects underwe... Seventy-two SLNs were surgically excised from 18 subjects, 29 were positive for blue dye, 63 were positive for radioactive tracer and 57 were positive for Sonazoid. Comparison with blue dye showed tha... Lymphosonography achieved similar accuracy as radioactive tracer and higher accuracy than blue dye for identifying SLNs. The 15 SLNs positive for malignancy were all identified by lymphosonography....
Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes.
Metastasis in a nonsentinel lymph node (non-SLN) is an unfavorable independent prognostic factor in cutaneous melanoma (CM). Recent data did suggest potential value of completion lymph node dissection... This retrospective study enrolled 656 cases of melanoma who underwent sentinel lymph node biopsy at Fudan University Shanghai Cancer Center from 2009 to 2017. We identified 81 SLN + AM patients who un... Ulceration, Clark level, number of deposits in the SLN (NumDep) and maximum size of deposits (MaxSize) are independent risk factors associated with non-SLN metastases. We developed a scoring system th... A scoring system that included ulceration, Clark level, MaxSize, and NumDep is reliable and effective for predicting non-SLN metastasis in SLN-positive AM....
Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer.
To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature.... Retrospective register-based study.... Copenhagen Oral Cavity Squamous Cell Carcinoma database.... Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival... In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve de... Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical q...
Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis.
The survival benefit of inguinal lymph node dissection (ILND) vs no ILND in patients with squamous cell carcinoma of the penis (SCCP) and the absence of lymph node invasion is unclear. We addressed th... We identified lymph node negative SCCP patients who either underwent ILND (pN0) or clinical examination only (cN0). We tested for the effect of ILND vs no ILND on cancer-specific mortality (CSM) in Ka... Of 2520 SCCP patients, 369 (15%) underwent ILND (pN0) vs 2151 (85%) did not (cN0). The pN0 vs cN0 distribution according to pT stages was as follows: 80 (7%) vs 1092 (93%) in pT1b, and 289 (21%) vs 10... In pT2-3 stage SCCP, a significantly lower CSM was recorded in lymph node negative patients treated with ILND than in their clinical lymph node negative counterparts who did not undergo ILND....