questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines et peptides de signalisation intracellulaire
Protein-Serine-Threonine Kinases
Mitogen-Activated Protein Kinases
JNK Mitogen-Activated Protein Kinases
JNK Mitogen-Activated Protein Kinases : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Kinases
Signalisation cellulaire
Biomarqueurs
Phosphorylation
Tests génétiques
Mutations
Imagerie par résonance magnétique
Effets cellulaires
Échantillons sanguins
Marqueurs d'activation
Symptômes
5
Cancer
Maladies neurodégénératives
Troubles cognitifs
Troubles de l'humeur
Prévention
5
Mode de vie sain
Alimentation équilibrée
Stress oxydatif
Gestion du stress
Antioxydants
Stress oxydatif
Exercice physique
Modulation
Habitudes alimentaires
Nutriments
Traitements
5
Inhibiteurs
Développement thérapeutique
Anti-inflammatoires
Modulation
Thérapie génique
Dysfonctionnements
Plantes médicinales
Activation
Traitements anticancéreux
Cellules tumorales
Complications
5
Maladies inflammatoires
Cancer
Complications cardiovasculaires
Maladies cardiovasculaires
Vieillissement cellulaire
Activation prolongée
Troubles neurodégénératifs
Activation
Troubles métaboliques
Diabète
Facteurs de risque
5
Stress
Inflammation chronique
Alimentation
Graisses saturées
Tabagisme
Facteurs de risque
Toxines environnementales
Activation
Mode de vie sédentaire
Facteurs de risque
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"@type": "Question",
"name": "Comment diagnostiquer une activation des JNK ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests de signalisation cellulaire et des analyses protéomiques peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels biomarqueurs indiquent l'activation des JNK ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des niveaux élevés de protéines phosphorylées c-Jun peuvent indiquer une activation."
}
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{
"@type": "Question",
"name": "Les tests génétiques sont-ils utiles pour les JNK ?",
"position": 3,
"acceptedAnswer": {
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"text": "Oui, des tests peuvent identifier des mutations affectant la voie JNK."
}
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{
"@type": "Question",
"name": "Quels examens d'imagerie sont utilisés pour les JNK ?",
"position": 4,
"acceptedAnswer": {
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"text": "L'imagerie par résonance magnétique peut aider à visualiser des effets cellulaires."
}
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{
"@type": "Question",
"name": "Peut-on mesurer l'activité des JNK dans le sang ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des échantillons sanguins peuvent être analysés pour des marqueurs d'activation."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à l'activation des JNK ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'activation peut entraîner inflammation, apoptose et dysfonction cellulaire."
}
},
{
"@type": "Question",
"name": "Les JNK sont-ils impliqués dans des maladies ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils sont associés à des maladies comme le cancer et les maladies neurodégénératives."
}
},
{
"@type": "Question",
"name": "Comment les JNK affectent-ils la douleur ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils modulent la signalisation de la douleur, contribuant à des douleurs chroniques."
}
},
{
"@type": "Question",
"name": "Les JNK influencent-ils le métabolisme ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils jouent un rôle dans la régulation du métabolisme énergétique."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes neurologiques associés aux JNK ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles cognitifs et des troubles de l'humeur peuvent être observés."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'activation des JNK ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, peut aider."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il les JNK ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress oxydatif peut activer les JNK, donc la gestion du stress est cruciale."
}
},
{
"@type": "Question",
"name": "Les antioxydants aident-ils à prévenir l'activation des JNK ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les antioxydants peuvent réduire le stress oxydatif et l'activation des JNK."
}
},
{
"@type": "Question",
"name": "L'exercice physique prévient-il l'activation des JNK ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut moduler positivement l'activité des JNK."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles les JNK ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en nutriments peut réduire l'activation des JNK."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent les JNK ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques des JNK sont en développement pour diverses maladies."
}
},
{
"@type": "Question",
"name": "Les anti-inflammatoires affectent-ils les JNK ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains anti-inflammatoires peuvent moduler l'activité des JNK."
}
},
{
"@type": "Question",
"name": "La thérapie génique peut-elle cibler les JNK ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est explorée pour corriger des dysfonctionnements des JNK."
}
},
{
"@type": "Question",
"name": "Les traitements naturels influencent-ils les JNK ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines plantes médicinales peuvent avoir un effet sur l'activation des JNK."
}
},
{
"@type": "Question",
"name": "Les traitements anticancéreux ciblent-ils les JNK ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traitements anticancéreux visent à inhiber les voies JNK dans les cellules tumorales."
}
},
{
"@type": "Question",
"name": "Quelles complications sont liées à l'activation des JNK ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'activation excessive des JNK peut entraîner des maladies inflammatoires et cancéreuses."
}
},
{
"@type": "Question",
"name": "Les JNK sont-ils liés à des complications cardiovasculaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'activation des JNK est associée à des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les JNK influencent-ils le vieillissement cellulaire ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activation prolongée des JNK peut accélérer le vieillissement cellulaire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications neurologiques liées aux JNK ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'activation des JNK est impliquée dans des troubles neurodégénératifs."
}
},
{
"@type": "Question",
"name": "Les JNK sont-ils impliqués dans des complications métaboliques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils sont liés à des troubles métaboliques comme le diabète."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque influencent les JNK ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress, l'inflammation chronique et l'obésité sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "L'alimentation affecte-t-elle les JNK ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en graisses saturées peut augmenter l'activation des JNK."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il les JNK ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme est un facteur de risque qui peut activer les JNK."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines affecte-t-elle les JNK ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines environnementales peut activer les JNK."
}
},
{
"@type": "Question",
"name": "Le manque d'exercice est-il un facteur de risque pour les JNK ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire peut augmenter le risque d'activation des JNK."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 04/02/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
From the Division of Pharmacology (M.S., K.J., K.H.), CSIR-Central Drug Research Institute, Lucknow, India.
Academy of Scientific and Innovative Research, Ghaziabad, India (M.S., K.J., K.H.).
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
From the Division of Pharmacology (M.S., K.J., K.H.), CSIR-Central Drug Research Institute, Lucknow, India.
Academy of Scientific and Innovative Research, Ghaziabad, India (M.S., K.J., K.H.).
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Division of Molecular and Structural Biology (N.K.V., J.K.G.), CSIR-Central Drug Research Institute, Lucknow, India.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Division of Molecular and Structural Biology (N.K.V., J.K.G.), CSIR-Central Drug Research Institute, Lucknow, India.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Institute for Zellbiochemie, Medizinische Hochschule Hannover (MHH), Hanover, Germany (M.G.).
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
From the Division of Pharmacology (M.S., K.J., K.H.), CSIR-Central Drug Research Institute, Lucknow, India.
Academy of Scientific and Innovative Research, Ghaziabad, India (M.S., K.J., K.H.).
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
College of Life Sciences and National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Department of Radiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Laboratório Especial de Dor e Sinalização, Instituto Butantan, São Paulo, Brazil.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Laboratório Especial de Dor e Sinalização, Instituto Butantan, São Paulo, Brazil.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
2 publications dans cette catégorie
Affiliations :
Laboratório Especial de Dor e Sinalização, Instituto Butantan, São Paulo, Brazil.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
Department of Life Science (BK21 program), Chung-Ang University, Seoul, South Korea.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
Department of Life Science (BK21 program), Chung-Ang University, Seoul, South Korea.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
Department of Life Science (BK21 program), Chung-Ang University, Seoul, South Korea.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
Department of Life Science (BK21 program), Chung-Ang University, Seoul, South Korea.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
College of Horticulture, Northwest A&F University, Yangling 712100, China. tayebmuhammad@nwsuaf.edu.cn.
State Key Laboratory of Crop Stress Biology in Arid Regions, Northwest A&F University, Yangling 712100, China. tayebmuhammad@nwsuaf.edu.cn.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
College of Horticulture, Northwest A&F University, Yangling 712100, China. 15591858981@163.com.
State Key Laboratory of Crop Stress Biology in Arid Regions, Northwest A&F University, Yangling 712100, China. 15591858981@163.com.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
College of Horticulture, Northwest A&F University, Yangling 712100, China. 15891785931@163.com.
State Key Laboratory of Crop Stress Biology in Arid Regions, Northwest A&F University, Yangling 712100, China. 15891785931@163.com.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
College of Horticulture, Northwest A&F University, Yangling 712100, China. liyushunaf@163.com.
State Key Laboratory of Crop Stress Biology in Arid Regions, Northwest A&F University, Yangling 712100, China. liyushunaf@163.com.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
1 publication dans cette catégorie
Affiliations :
College of Horticulture, Northwest A&F University, Yangling 712100, China. feizhang@nwsuaf.edu.cn.
Publications dans "JNK Mitogen-Activated Protein Kinases" :
In occupational therapy and -science positive aspects of occupation are highlighted. Recently, this discourse has been questioned, as it might leave out occupations - referred to as unilluminated occu...
To translate UO into Danish and to examine how occupational therapists (OTs) view and address UO....
A survey developed in USA was translated into Danish and distributed to OTs across Denmark. We added questions on the Danish wording of the concepts, including a content validity index (CVI). Data was...
The respondents agreed that OTs must include examining the purpose and meaning of UO, however without having a responsibility to support performing these UO. The applied translation: high risk (risika...
Although most respondents were positive towards examining and acknowledging clients' purpose and meaning of UO, no clear consensus when addressing UO in interventions was seen. Further research might ...
There is a lack of evidence-based knowledge in paediatric occupational therapy about the effectiveness of interventions using daily activities as a treatment modality in improving children's participa...
This study aimed to evaluate the effectiveness of occupation-based and occupation-focused interventions in improving participation in everyday occupations for young children with a disability....
A systematic review based on Joanna Briggs Institute methodology and critical appraisal tools was conducted. Six databases were searched for quantitative intervention studies aimed at improving partic...
The search yielded 3732 records, of which 13 studies met inclusion criteria. Ten studies met methodological quality criteria and were included in the synthesis, five randomised controlled trials and f...
Occupation-based and occupation-focused interventions may have a positive effect on participation in everyday occupations for young children with a disability, but study design, risk of bias and insuf...
Occupation-centred practice is core to contemporary occupational therapy; however, knowledge and implementation of occupation in practice vary. New graduate occupational therapists find implementing o...
Interpretative phenomenology was used as the research design. Ten senior occupational therapists in Australia were purposively recruited to participate in semi-structured interviews, which we transcri...
Five themes were discovered from the data: together, but apart; a link between knowledge and identity; navigating different cultures; making up for what is missing; and good supervisors. The themes re...
Senior occupational therapists valued occupation-centred practice, but their understanding and implementation of it varied. Participants acknowledged that they held great power to influence new gradua...
In many countries, labor markets are still highly gender segregated, with very few men working in communal occupations such as nursing. Because occupational aspirations start to develop during early c...
A substantial proportion of all reported occupational illnesses are constituted by skin cancer, making this disease a serious public health issue. Solar ultra-violet radiation (UVR) exposure is the mo...
To describe the association between occupations and suicide, and to explore the effect of gender dominance in the occupation and in the workplace on the risk of suicide....
Register-based cohort study....
3 318 050 workers in Sweden in 2005 and followed up until 2010. Exclusion criteria for the study were: missing information in the occupational codes, yearly income of <100 Swedish krona, missing infor...
Suicides occurring during 2006-2010 identified in the cause of death register by the International Classification of Diagnoses-10 codes X60-84 and Y10-34....
Occupations with increased suicide were life science and health professionals (OR: 2.8, 95% CI: 1.50 to 5.26) among women. In men, these were metal, machinery and related workers (OR: 1.5, 95% CI: 1.0...
This study found that women in the 'life science and health professionals' group and men in the 'metal, machinery and related workers' as well as 'personal and protective service workers' groups have ...
The aim of the study is to analyze the epidemiological situation regarding the occurrence of occupational diseases in Poland in 2020 and to define possible directions for recommendations regarding pre...
The cases of occupational diseases identified in accordance with the Polish judicial system and reported to the Central Register of Occupational Diseases in 2020 were analyzed. The analysis took into ...
In 2020, 1850 cases of occupational diseases were diagnosed in Poland (11.5 cases per 100 000 employees). The disease entities with the highest incidence were infectious or parasitic diseases, pneumoc...
The epidemiological situation in the field of occupational diseases in our country indicates a disturbing phenomenon, which is the persistence of a high level of pneumoconiosis of hard coal miners. Th...
This study describes the characteristics of workers experiencing occupational heat-related injuries/illnesses in the United States and explores the associations between states' average annual temperat...
The number and rate of occupational environmental heat injuries/illnesses were calculated according to age group, gender, race/ethnicity, occupation group, and state from 2011 to 2019....
Injury/illness rates were higher among Black and Hispanic workers. Workers in farming, fishing, and forestry; installation, maintenance, and repair; and construction/extraction occupations had the hig...
There are demographic and occupational disparities in occupational environmental heat-related injuries/illnesses in the United States and a correlation between these injuries/illnesses and state avera...
Science and scientists are among the key drivers of societal progress and technological developments. While research has demonstrated that science is perceived as heterogeneous, work on perceptions of...
We examined whether low literacy skills are a risk factor for occupational injury during a 5.3-year follow-up period....
The study population was taken from the Danish participants in the Programme for the International Assessment of Adult Competencies (PIAAC) in 2011/2012. Literacy skills were based on the PIAAC survey...
Literacy skills were divided into four categories based on the six levels of skills in PIAAC. With the highest level of literacy skills as the reference (level 4/5), the hazard ratios for occupational...
Employees with a low level of literacy skills are at a higher risk of occupational injury than employees with a high level of literacy skills....