questionsmedicales.fr
Phénomènes génétiques
Régulation de l'expression des gènes
Modification traductionnelle des protéines
Maturation post-traductionnelle des protéines
Réponse aux protéines mal repliées
Réponse aux protéines mal repliées : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Réponse aux protéines mal repliées
Stress cellulaire
Biopsie
Analyse protéomique
Imagerie médicale
Complications
Biomarqueurs
Protéines chaperonnes
Antécédents médicaux
Maladies métaboliques
Symptômes
5
Fatigue
Troubles métaboliques
Douleur musculaire
Douleur articulaire
Troubles cognitifs
Céphalée
Métabolisme
Résistance à l'insuline
Nausées
Troubles gastro-intestinaux
Prévention
5
Mode de vie sain
Gestion du stress
Bilan de santé
Prévention
Éducation à la santé
Sensibilisation
Soutien psychologique
Santé mentale
Traitements
5
Thérapies ciblées
Médicaments anti-inflammatoires
Exercice physique
Stress cellulaire
Inhibiteurs de protéase
Médicaments
Thérapie génique
Recherche
Complications
5
Maladies métaboliques
Cancers
Troubles cardiovasculaires
Inflammation
Facteurs de risque
5
Stress oxydatif
Prédispositions génétiques
Vieillissement
Dysfonctionnement
Mode de vie sédentaire
Alimentation
Maladies auto-immunes
Exacerbation
Tabagisme
Stress cellulaire
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"@type": "Question",
"name": "L'évitement de toxines est-il important ?",
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"@type": "Question",
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"position": 13,
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"name": "L'alimentation influence-t-elle l'UPR ?",
"position": 17,
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}
},
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"@type": "Question",
"name": "Les exercices physiques sont-ils bénéfiques ?",
"position": 18,
"acceptedAnswer": {
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"text": "Oui, l'exercice modéré peut améliorer la réponse au stress cellulaire."
}
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"@type": "Question",
"name": "Des médicaments spécifiques sont-ils prescrits ?",
"position": 19,
"acceptedAnswer": {
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"text": "Des médicaments comme les inhibiteurs de la protéase peuvent être utilisés."
}
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"@type": "Question",
"name": "La thérapie génique est-elle une option ?",
"position": 20,
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"text": "La thérapie génique est en recherche pour corriger des défauts liés à l'UPR."
}
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"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies métaboliques, des troubles neurologiques et des cancers peuvent survenir."
}
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"@type": "Question",
"name": "L'UPR peut-elle entraîner des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
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"text": "Oui, l'UPR est liée à des maladies chroniques comme le diabète et l'obésité."
}
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{
"@type": "Question",
"name": "Y a-t-il un risque accru de cancer ?",
"position": 23,
"acceptedAnswer": {
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"text": "Oui, l'UPR est associée à un risque accru de certains types de cancer."
}
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"@type": "Question",
"name": "Des troubles cardiovasculaires sont-ils possibles ?",
"position": 24,
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"text": "Oui, l'UPR peut contribuer à des troubles cardiovasculaires et à l'inflammation."
}
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"@type": "Question",
"name": "L'UPR affecte-t-elle la longévité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent que l'UPR peut influencer la longévité et la santé globale."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de l'UPR ?",
"position": 26,
"acceptedAnswer": {
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"text": "Les facteurs incluent le stress oxydatif, l'inflammation et des prédispositions génétiques."
}
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{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
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"text": "Oui, le vieillissement augmente le risque de dysfonctionnement de l'UPR."
}
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{
"@type": "Question",
"name": "Le mode de vie influence-t-il l'UPR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
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{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles un risque ?",
"position": 29,
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"text": "Oui, les maladies auto-immunes peuvent exacerber la réponse aux protéines mal repliées."
}
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"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 30,
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 08/04/2025
Contenu vérifié selon les dernières recommandations médicales
9 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.
3 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
MSU-DOE Plant Research Lab and Plant Biology Department Michigan State University, East Lansing, MI, USA. fb@msu.edu.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Neuroscience; Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Orthopedics, University of Colorado Anschutz Medical Campus, 12800 E 19th Ave, Mailstop:8343, Aurora, CO, 80045, USA. Srividhya.Iyer@cuanschutz.edu.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. chetz@med.uchile.cl.
FONDAP Center for Geroscience Brain Health and Metabolism (GERO), Santiago, Chile. chetz@med.uchile.cl.
Program of Cellular and Molecular Biology, Institute of Biomedical Science, University of Chile, Santiago, Chile. chetz@med.uchile.cl.
Buck Institute for Research on Aging, Novato, CA, USA. chetz@med.uchile.cl.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Medical Biochemistry and Molecular Biology, Medical Faculty, Saarland University, 66421 Homburg, Germany.
Preclinical Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, 66421 Homburg, Germany.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Milano 20133, Italy.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Milano 20133, Italy.
Publications dans "Réponse aux protéines mal repliées" :
1 publication dans cette catégorie
Affiliations :
Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.
Biophysical Sciences Institute, Durham University, South Road, Durham DH1 3LE, UK.
Publications dans "Réponse aux protéines mal repliées" :
1 publication dans cette catégorie
Affiliations :
Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.
Biophysical Sciences Institute, Durham University, South Road, Durham DH1 3LE, UK.
Publications dans "Réponse aux protéines mal repliées" :
Background and Objectives: Migraines are one of the most common types of primary headaches in neurology. Many studies to date have investigated cognitive impairment in migraineurs, but the results are...
Post-operative cognitive dysfunction (POCD) is a concern for clinicians that often presents post-surgery where generalized anesthesia has been used. Its prevalence ranges from 36.6% in young adults to...
The reporting of our review was guided by the PRISMA statement and the 6-step evolutionary approach to concept analysis developed by Rodgers. Three databases, including Medline, CINAHL, and Web of Sci...
POCD was defined with varying severities ranging from subtle-to-extensive cognitive changes (1) affecting single or multiple cognitive domains that manifest following major surgery (2), is transient a...
This review resulted in a refined definition and comprehensive analysis of POCD that can be useful to both researchers and clinicians. Future research is needed to refine the operational definitions o...
Hypertension affects a significant proportion of the adult and aging population and represents an important risk factor for vascular cognitive impairment and late-life dementia. Chronic high blood pre...
Microvascular function in the brain and heart may play an important role in the course of patients with heart failure (HF), but its relationship with ventricular and cognitive function is not well und...
In healthy controls and symptomatic patients with HF (New York Heart Association functional class II or III), we used oxygenation-sensitive magnetic resonance imaging during a standardized breathing m...
Twenty patients with HF (age 64.4±8.3 years; 50% female sex), and 21 healthy controls (age 55.0±5.1 years; 62% female sex) were included in the analysis. In patients with HF, cerebral oxygenation rese...
Our results indicate that heart failure is an independent predictor of coronary and cerebral microvascular dysfunction as defined by a reduced response to a vasodilatory breathing maneuver. This impai...
The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive dysfunction after basal ganglia stroke, and factors affecting total MoCA score were examined....
Data were retrospectively analyzed for 30 patients with basal ganglia intracerebral hemorrhage or basal ganglia cerebral infarction, who were admitted to The Second Affiliated Hospital of Fujian Tradi...
Univariate linear regression showed that the total MoCA score was significantly associated with sex, age, executive function, naming, attention, abstract generalization ability, memory ability, and vi...
We showed that the MoCA test can be used for patients with basal ganglia stroke. The total MoCA score of basal ganglia stroke was significantly associated with impairments in executive function, namin...
The aim of this review is to summarize the current evidence on the relationship between sleep and cognition and present available data reporting the impact that sleep alterations may have on cognitive...
Research findings support the idea that sleep is involved in cognitive processes and that altered sleep homeostasis or circadian rhythms may lead to clinical and biochemical changes associated with co...
The coronavirus (COVID-19) pandemic is still evolving, causing hundreds of millions of infections around the world. The long-term sequelae of COVID-19 and neurologic syndromes post COVID remain poorly...
Recent evidence has shown that vestibular migraine is strongly associated with cognitive difficulties. However, limited data exist on real-world effects of that dysfunction. The objective of this stud...
Randomized, population-based survey study of US adults....
We generated a case definition approximating probable vestibular migraine based on Bárány Society criteria and validated that definition in a tertiary care vestibular clinic....
Adult respondents to the 2016 NHIS, which queries a representative sample of the civilian, noninstitutionalized US population....
Diagnostic....
We evaluated incidence of self-reported cognitive dysfunction with vestibular migraine and whether individuals were more likely to have impaired mobility, falls, and work absenteeism than those withou...
Among individuals with vestibular migraine, 40% reported "some" and 12% reported "a lot" of difficulty thinking versus 13% and 2% of those without vestibular migraine, respectively. Vestibular migrain...
Our findings indicate vestibular migraine is not only associated with cognitive dysfunction, but they are together associated with mobility issues, fall risk, and work absenteeism....
With the ageing of the population, the health problems of elderly individuals have become particularly important. Through a large number of clinical studies and trials, it has been confirmed that elde...
To characterize visuospatial and nonvisuospatial cognitive domains affected by vestibular loss and determine whether patient-reported outcomes measures (PROMs) correlate with performance on neuropsych...
Cross-sectional study....
University-based tertiary medical center....
Sixty-nine age-matched subjects: 25 patients with bilateral vestibular loss (BVL), 14 patients with unilateral vestibular loss (UVL), and 30 normal controls (NC)....
Neuropsychological tests used to assess visuospatial and auditory short-term and working memory, number magnitude representation, executive function, and attention. Validated PROMs used to evaluate qu...
Performance on neuropsychological tests and scores on PROM surveys....
BVL and UVL patients performed significantly worse than NC subjects on tasks requiring visuospatial representation compared with NC subjects ( p < 0.01). BVL patients demonstrated decreased performanc...
Patients with vestibular loss exhibit impairments in tasks requiring visuospatial representation but perform similarly to NC subjects in tasks of auditory working memory, executive function, or attent...