questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines et peptides de signalisation intracellulaire
Phosphatidylinositol 3-kinases
Phosphatidylinositol-4-phosphate 3-kinase
Phosphatidylinositol-4-phosphate 3-kinase : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Kinases
Diagnostic médical
Tests de laboratoire
Phosphatidylinositols
Biopsie
Phosphatidylinositols
Symptômes
Phosphatidylinositols
Marqueurs biologiques
Phosphatidylinositols
Symptômes
5
Symptômes
Phosphatidylinositols
Troubles neurologiques
Phosphatidylinositols
Anomalies cutanées
Phosphatidylinositols
Douleurs articulaires
Phosphatidylinositols
Prévention
5
Prévention
Mode de vie sain
Dépistage
Tests génétiques
Habitudes alimentaires
Phosphatidylinositols
Exercice physique
Métabolisme
Facteurs environnementaux
Phosphatidylinositols
Traitements
5
Inhibiteurs
Traitement du cancer
Thérapie génique
Phosphatidylinositols
Effets secondaires
Inhibiteurs
Médecine personnalisée
Phosphatidylinositols
Complications
5
Complications
Phosphatidylinositols
Maladies cardiovasculaires
Phosphatidylinositols
Cancer
Phosphatidylinositols
Résistance aux traitements
Phosphatidylinositols
Troubles métaboliques
Phosphatidylinositols
Facteurs de risque
5
Facteurs de risque
Obésité
Âge
Phosphatidylinositols
Stress
Phosphatidylinositols
Antécédents familiaux
Phosphatidylinositols
Alimentation
Phosphatidylinositols
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"description": "Comment diagnostiquer une dysfonction de PI3K ?\nQuels tests sont utilisés pour évaluer PI3K ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec PI3K ?\nY a-t-il des marqueurs spécifiques pour PI3K ?",
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction de PI3K ?",
"position": 1,
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"text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer les anomalies de PI3K."
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer PI3K ?",
"position": 2,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec PI3K ?",
"position": 4,
"acceptedAnswer": {
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"text": "Des symptômes variés comme des troubles métaboliques ou des anomalies de croissance peuvent survenir."
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"@type": "Question",
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"@type": "Question",
"name": "Quels sont les symptômes d'une activation anormale de PI3K ?",
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"@type": "Question",
"name": "Comment PI3K affecte-t-il le métabolisme ?",
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"@type": "Question",
"name": "Les troubles neurologiques sont-ils liés à PI3K ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dysfonctionnements de PI3K peuvent être associés à des troubles neurologiques."
}
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{
"@type": "Question",
"name": "Y a-t-il des signes cutanés associés à PI3K ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies cutanées peuvent apparaître, notamment dans des syndromes génétiques liés à PI3K."
}
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{
"@type": "Question",
"name": "Les douleurs articulaires peuvent-elles être liées à PI3K ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles inflammatoires peuvent être exacerbés par des anomalies de PI3K."
}
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{
"@type": "Question",
"name": "Peut-on prévenir les troubles liés à PI3K ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation saine et un mode de vie actif peuvent réduire les risques associés à PI3K."
}
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{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour PI3K ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être recommandés pour les personnes à risque de troubles liés à PI3K."
}
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{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles PI3K ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en acides gras oméga-3 peut moduler l'activité de PI3K."
}
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{
"@type": "Question",
"name": "L'exercice physique aide-t-il à réguler PI3K ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la signalisation de PI3K et la santé métabolique."
}
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"@type": "Question",
"name": "Les facteurs environnementaux affectent-ils PI3K ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains toxiques peut influencer l'activité de PI3K et le risque de maladies."
}
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{
"@type": "Question",
"name": "Quels traitements ciblent PI3K ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de PI3K sont utilisés dans le traitement de certains cancers et maladies métaboliques."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique peut corriger des mutations dans les gènes codant pour PI3K."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires des inhibiteurs de PI3K ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure des troubles gastro-intestinaux et des infections."
}
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{
"@type": "Question",
"name": "Comment la nutrition influence-t-elle PI3K ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut moduler l'activité de PI3K et améliorer la santé métabolique."
}
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour PI3K ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques de PI3K."
}
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{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec PI3K ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles métaboliques et des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées à PI3K ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies de PI3K peuvent contribuer à des maladies cardiovasculaires par des mécanismes inflammatoires."
}
},
{
"@type": "Question",
"name": "Comment PI3K influence-t-il le cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "PI3K est souvent activé dans divers cancers, favorisant la croissance tumorale et la survie cellulaire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de résistance aux traitements ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations dans PI3K peuvent entraîner une résistance aux inhibiteurs de PI3K."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains troubles métaboliques liés à PI3K peuvent être gérés par des changements de mode de vie."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles de PI3K ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques, l'obésité et un mode de vie sédentaire."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque lié à PI3K ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de troubles liés à PI3K augmente avec l'âge en raison de l'accumulation de mutations."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur PI3K ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la signalisation de PI3K et contribuer à des maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers ou de troubles métaboliques augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le risque de troubles de PI3K ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en sucres et graisses saturées peut augmenter le risque."
}
}
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 27/02/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Cellular Organization and Signaling, National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore, 560065, India. Electronic address: praghu@ncbs.res.in.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA ballat@mail.nih.gov.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. haucke@fmp-berlin.de.
Departments of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany. haucke@fmp-berlin.de.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Medical Research Institute, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan. Electronic address: afujita@vet.kagoshima-u.ac.jp.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry, University of Toronto, ON, M5S 1A8, Toronto, Canada. greg.fairn@unityhealth.to.
Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada. greg.fairn@unityhealth.to.
Department of Surgery, University of Toronto, Toronto, ON, M5T 1P5, Canada. greg.fairn@unityhealth.to.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
Ultrasound of the elbow can be incorporated into routine pediatric practice in the radiology department, emergency department, orthopedic clinic, and interventional suite. Ultrasound is complementary ...
We aim to asses the diagnostic performance of ankle ultrasonography in patients presenting with acute ankle sprain injury, with comparison to MRI (Manyetik Rezonans İmaging)....
The study included patients who applied to the hospital within 48 h after an ankle sprain, and who presented with signs of pain, swelling, and tenderness in the ankle. Ankle ultrasonography examinatio...
30 patients were included in the study. 53.3% (n = 16) were female. The mean age was 30 ± 6.4 years. The ultrasonography examination determined 76.6% (n = 23) of the patients to have anterior talofibu...
Findings on all types of ATFL, CFL and AITFL appear to have a higher degree of correlation. Ultrasonography could have an added role as a triaging tool, to fast-track MRI....
We aimed to evaluate ultrasonography (US), colour Doppler US (CDUS) and sonoelastography (SEL) findings of histopathologically proven abdominal wall scar endometriosis in comparison with menstrual pha...
Artificial intelligence (AI) continues to change paradigms in the field of medicine with new applications that are applicable to daily life. The field of ultrasonography, which has been developing sin...
Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense system...
Rapid diagnostic tools available to the emergency physician caring for cardiac arrest patients are limited. Focused ultrasound (US), and in particular, focused echocardiography, is a useful tool in th...
This case image demonstrates the usefulness of vulvar ultrasound in the diagnosis of vulvar abscess....
Levator ani defect (LAD) closely correlates with pelvic floor disorders (PFD). In general, LAD was graded by three-dimensional ultrasonography (3D-US) and MRI, which could be used hardly in some devel...
Chronic trigonitis (CT) is usually diagnosed through cystoscopy which is invasive and expensive. Thus, an accurate non-invasive diagnostic method is necessary. The objective of this study is to determ...
Between 2012 and 2021, 114 women (17-76 years old) with recurrent urinary tract infection (RUTI) and history of antibiotic resistance were evaluated with TBU by a single ultrasonographer. As a control...
Thickening of trigone mucosa (>3 mm) was detected in all patients with RUTI and represented the most relevant criteria for trigonitis diagnosis on TBU. Other TBU findings in CT are: irregular and inte...
TBU proved to be an efficient, inexpensive and minimally invasive method to diagnose CT. To our knowledge, this is the first article that reports the use of transvaginal ultrasound as an alternative m...
Gastric tubes are commonly used for the administration of drugs and tube feeding for people who are unable to swallow. Feeding via a tube misplaced in the trachea can result in severe pneumonia. There...
To assess the diagnostic accuracy of ultrasound alone or in combination with other methods for gastric tube placement confirmation in children and adults....
This systematic review is an update of a previously published Cochrane review. For this update, we searched the Cochrane Library (2021, Issue 6), MEDLINE (to April 2023), Embase (to April 2023), five ...
We included studies that evaluated the diagnostic accuracy of naso- and orogastric tube placement confirmed by ultrasound visualization using X-ray visualization as the reference standard. We included...
Two review authors independently assessed the methodological quality and extracted data from each of the included studies. We contacted the authors of the included studies to obtain missing data. Ther...
We identified 12 new studies in addition to 10 studies included in the earlier version of this review, totalling 1939 participants and 1944 tube insertions. Overall, we judged the risk of bias in the ...
Of 22 studies that assessed the diagnostic accuracy of gastric tube placement, few studies had a low risk of bias. Based on limited evidence, ultrasound does not have sufficient accuracy as a single t...