Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy.
Break-induced replication
CRISPR-Cas9
Gene conversion
Single-strand annealing
TALEN
ZFN
Journal
Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
30
04
2018
accepted:
01
07
2018
revised:
25
06
2018
pubmed:
6
7
2018
medline:
28
5
2019
entrez:
6
7
2018
Statut:
ppublish
Résumé
Trinucleotide repeats are a particular class of microsatellites whose large expansions are responsible for at least two dozen human neurological and developmental disorders. Slippage of the two complementary DNA strands during replication, homologous recombination or DNA repair is generally accepted as a mechanism leading to repeat length changes, creating expansions and contractions of the repeat tract. The present review focuses on recent developments on double-strand break repair involving trinucleotide repeat tracts. Experimental evidences in model organisms show that gene conversion and break-induced replication may lead to large repeat tract expansions, while frequent contractions occur either by single-strand annealing between repeat ends or by gene conversion, triggering near-complete contraction of the repeat tract. In the second part of this review, different therapeutic approaches using highly specific single- or double-strand endonucleases targeted to trinucleotide repeat loci are compared. Relative efficacies and specificities of these nucleases will be discussed, as well as their potential strengths and weaknesses for possible future gene therapy of these dramatic disorders.
Identifiants
pubmed: 29974202
doi: 10.1007/s00294-018-0865-1
pii: 10.1007/s00294-018-0865-1
doi:
Substances chimiques
DNA
9007-49-2
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-28Références
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