Yeast Expression Systems: Overview and Recent Advances.

Expression system Hansenula polymorpha Pichia pastoris Saccharomyces cerevisiae Yarrowia lipolytica

Journal

Molecular biotechnology
ISSN: 1559-0305
Titre abrégé: Mol Biotechnol
Pays: Switzerland
ID NLM: 9423533

Informations de publication

Date de publication:
May 2019
Historique:
pubmed: 26 2 2019
medline: 26 7 2019
entrez: 27 2 2019
Statut: ppublish

Résumé

Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins' expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe. This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.

Identifiants

pubmed: 30805909
doi: 10.1007/s12033-019-00164-8
pii: 10.1007/s12033-019-00164-8
doi:

Substances chimiques

Recombinant Proteins 0

Types de publication

Journal Article Review

Langues

eng

Pagination

365-384

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Auteurs

Roghayyeh Baghban (R)

Medical Biotechnology Department, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnology Research Center, Tabriz University of Medical Sciences, Daneshgah Ave, Tabriz, Iran.

Safar Farajnia (S)

Biotechnology Research Center, Tabriz University of Medical Sciences, Daneshgah Ave, Tabriz, Iran. farajnias@tbzmed.ac.ir.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. farajnias@tbzmed.ac.ir.

Masoumeh Rajabibazl (M)

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Velenjak, Arabi Ave, Tehran, Iran. rajabi_m@sbmu.ac.ir.
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rajabi_m@sbmu.ac.ir.

Younes Ghasemi (Y)

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz, Iran.

AmirAli Mafi (A)

Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Reyhaneh Hoseinpoor (R)

Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Leila Rahbarnia (L)

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Maryam Aria (M)

Biotechnology Research Center, Tabriz University of Medical Sciences, Daneshgah Ave, Tabriz, Iran.

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Classifications MeSH