Speech treatment improves dysarthria in multisystemic ataxia: a rater-blinded, controlled pilot-study in ARSACS.
Acoustics
Ataxic neuropathy
Dysarthria
Rehabilitation
Speech
Voice
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
23
11
2018
accepted:
21
02
2019
revised:
14
02
2019
pubmed:
7
3
2019
medline:
14
8
2019
entrez:
7
3
2019
Statut:
ppublish
Résumé
We aimed to provide proof-of-principle evidence that intensive home-based speech treatment can improve dysarthria in complex multisystemic degenerative ataxias, exemplified by autosomal recessive spastic ataxia Charlevoix-Saguenay (ARSACS). Feasibility and piloting efficacy of speech training specifically tailored to cerebellar dysarthria was examined through a 4-week program in seven patients with rater-blinded assessment of intelligibility (primary outcome) and naturalness and acoustic measures of speech (secondary outcomes) performed 4 weeks before, immediately prior to, and directly after training (intraindividual control design). Speech intelligibility and naturalness improved post treatment. This provides piloting evidence that ataxia-tailored speech treatment might be effective in degenerative cerebellar disease.
Identifiants
pubmed: 30840144
doi: 10.1007/s00415-019-09258-4
pii: 10.1007/s00415-019-09258-4
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Pagination
1260-1266Subventions
Organisme : National Health and Medical Research Council
ID : 1082910
Organisme : H2020 Excellent Science
ID : 643578
Organisme : BMBF
ID : 01GM1607
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