Inherited IL-18BP deficiency in human fulminant viral hepatitis.


Journal

The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R

Informations de publication

Date de publication:
05 08 2019
Historique:
received: 12 04 2019
revised: 14 05 2019
accepted: 15 05 2019
pubmed: 20 6 2019
medline: 20 6 2020
entrez: 20 6 2019
Statut: ppublish

Résumé

Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in

Identifiants

pubmed: 31213488
pii: jem.20190669
doi: 10.1084/jem.20190669
pmc: PMC6683989
doi:

Substances chimiques

IL18 protein, human 0
Intercellular Signaling Peptides and Proteins 0
Interleukin-18 0
interleukin-18 binding protein 0

Types de publication

Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1777-1790

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI091707
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM066699
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2019 Belkaya et al.

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Auteurs

Serkan Belkaya (S)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.

Eleftherios Michailidis (E)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.

Cecilia B Korol (CB)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Mohammad Kabbani (M)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.

Aurélie Cobat (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Paul Bastard (P)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.

Yoon Seung Lee (YS)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.

Nicholas Hernandez (N)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.

Scott Drutman (S)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.

Ype P de Jong (YP)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY.

Eric Vivier (E)

Aix Marseille Université, INSERM, Centre National de la Recherche Scientifique, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Service d'Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.

Julie Bruneau (J)

Paris Descartes University, Imagine Institute, Paris, France.
Department of Pathology, Assistance Publique-Hôpitaux de Paris, Necker Hospital for Sick Children, Paris, France.

Vivien Béziat (V)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Bertrand Boisson (B)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Lazaro Lorenzo-Diaz (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Soraya Boucherit (S)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Mylène Sebagh (M)

Department of Pathology, Hepato-biliary Center, Assistance Publique-Hôpitaux de Paris, Paul Brousse Hospital, Villejuif, France.

Emmanuel Jacquemin (E)

Pediatric Hepatology and Liver Transplantation Unit, National Reference Centre for Rare Pediatric Liver Diseases, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, University of Paris Sud-Saclay, Le Kremlin Bicêtre, France.
INSERM U1174, University of Paris Sud-Saclay, Hepatinov, Orsay, France.

Jean-François Emile (JF)

Department of Pathology, Assistance Publique-Hôpitaux de Paris, Ambroise Paré Hospital, Boulogne-Billancourt, France.

Laurent Abel (L)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Charles M Rice (CM)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.

Emmanuelle Jouanguy (E)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.

Jean-Laurent Casanova (JL)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY jean-laurent.casanova@rockefeller.edu.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Paris Descartes University, Imagine Institute, Paris, France.
Pediatric Immunology-Hematology Unit, Necker Hospital for Sick Children, Paris, France.
Howard Hughes Medical Institute, New York, NY.

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Classifications MeSH