Tunicamycin: chemical synthesis and biosynthesis.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
03
2019
accepted:
27
05
2019
revised:
20
05
2019
pubmed:
27
6
2019
medline:
28
4
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
Tunicamycins are nucleoside natural products and show antibacterial, antiviral and antitumor activities, which are attributed to their inhibition of enzymatic reactions between polyisoprenyl phosphate and UDP-GlcNAc or UDP-MurNAc-pentapeptide. Because of their various intriguing biological activities, tunicamycins have potential as therapeutic agents for infectious diseases or cancers. Structurally, tunicamycins have a unique structure composed of an undecodialdose skeleton, a lipid chain and a GlcNAc fragment linked by a 1,1-β,α-trehalose-type glycosidic bond. In this mini review, we summarize the total chemical syntheses and biosynthetic studies of tunicamycins.
Identifiants
pubmed: 31235901
doi: 10.1038/s41429-019-0200-1
pii: 10.1038/s41429-019-0200-1
doi:
Substances chimiques
Tunicamycin
11089-65-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
924-933Références
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