Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 2019
Historique:
received: 28 10 2018
accepted: 28 06 2019
pubmed: 2 8 2019
medline: 22 1 2020
entrez: 2 8 2019
Statut: ppublish

Résumé

Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants. Central to the stress response are dynamic changes in metabolism, such as the transition from the glycolysis to the pentose phosphate pathway-a conserved first-line response to oxidative insults

Identifiants

pubmed: 31367038
doi: 10.1038/s41586-019-1442-6
pii: 10.1038/s41586-019-1442-6
pmc: PMC6774798
mid: EMS83570
doi:

Substances chimiques

Antioxidants 0
Antiporters 0
Organic Cation Transport Proteins 0
Oxidants 0
Polyamines 0
Reactive Oxygen Species 0
Saccharomyces cerevisiae Proteins 0
TPO1 protein, S cerevisiae 0
Glutamine 0RH81L854J
NADP 53-59-8
Ornithine Decarboxylase EC 4.1.1.17
SPE1 protein, S cerevisiae EC 4.1.1.17
Glutathione GAN16C9B8O
Lysine K3Z4F929H6
Cadaverine L90BEN6OLL

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

249-253

Subventions

Organisme : Wellcome Trust
ID : 200829
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001134
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001134
Pays : United Kingdom
Organisme : Austrian Science Fund FWF
ID : W 1224
Pays : Austria
Organisme : European Research Council
ID : 260809
Pays : International
Organisme : Wellcome Trust
ID : FC001134
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

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Auteurs

Viridiana Olin-Sandoval (V)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
Department of Nutrition Physiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Jason Shu Lim Yu (JSL)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.

Leonor Miller-Fleming (L)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

Mohammad Tauqeer Alam (MT)

Warwick Medical School, University of Warwick, Coventry, UK.

Stephan Kamrad (S)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Department of Genetics, Evolution & Environment, University College London, London, UK.

Clara Correia-Melo (C)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.

Robert Haas (R)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.

Joanna Segal (J)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.

David Alejandro Peña Navarro (DA)

Department of Biotechnology, BOKU - University of Natural Resources and Life Sciences, Vienna, Austria.

Lucia Herrera-Dominguez (L)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.

Oscar Méndez-Lucio (O)

Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Jakob Vowinckel (J)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
Biognosys AG, Schlieren, Switzerland.

Michael Mülleder (M)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Department of Biochemistry, Charité University Medicine, Berlin, Germany.

Markus Ralser (M)

Department of Biochemistry, University of Cambridge, Cambridge, UK. markus.ralser@crick.ac.uk.
The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK. markus.ralser@crick.ac.uk.
Department of Biochemistry, Charité University Medicine, Berlin, Germany. markus.ralser@crick.ac.uk.

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Classifications MeSH