An ancestral NB-LRR with duplicated 3'UTRs confers stripe rust resistance in wheat and barley.
3' Untranslated Regions
/ genetics
Alleles
Basidiomycota
/ physiology
Chromosome Mapping
Disease Resistance
/ genetics
Gene Duplication
Gene Expression Regulation, Plant
Genes, Plant
/ genetics
Hordeum
/ classification
Mutation
Phylogeny
Plant Diseases
/ genetics
Plants, Genetically Modified
Triticum
/ classification
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 09 2019
06 09 2019
Historique:
received:
15
01
2019
accepted:
05
08
2019
entrez:
8
9
2019
pubmed:
8
9
2019
medline:
31
12
2019
Statut:
epublish
Résumé
Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a global threat to wheat production. Aegilops tauschii, one of the wheat progenitors, carries the YrAS2388 locus for resistance to Pst on chromosome 4DS. We reveal that YrAS2388 encodes a typical nucleotide oligomerization domain-like receptor (NLR). The Pst-resistant allele YrAS2388R has duplicated 3' untranslated regions and is characterized by alternative splicing in the nucleotide-binding domain. Mutation of the YrAS2388R allele disrupts its resistance to Pst in synthetic hexaploid wheat; transgenic plants with YrAS2388R show resistance to eleven Pst races in common wheat and one race of P. striiformis f. sp. hordei in barley. The YrAS2388R allele occurs only in Ae. tauschii and the Ae. tauschii-derived synthetic wheat; it is absent in 100% (n = 461) of common wheat lines tested. The cloning of YrAS2388R will facilitate breeding for stripe rust resistance in wheat and other Triticeae species.
Identifiants
pubmed: 31492844
doi: 10.1038/s41467-019-11872-9
pii: 10.1038/s41467-019-11872-9
pmc: PMC6731223
doi:
Substances chimiques
3' Untranslated Regions
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4023Références
Nat Genet. 2015 Dec;47(12):1494-8
pubmed: 26551671
New Phytol. 2013 May;198(3):925-37
pubmed: 23374069
Nat Plants. 2018 Sep;4(9):662-668
pubmed: 30150615
Plant Dis. 2014 Nov;98(11):1534-1542
pubmed: 30699782
J Biol Chem. 2013 Dec 13;288(50):35868-76
pubmed: 24194517
J Genet Genomics. 2012 Nov 20;39(11):587-92
pubmed: 23177146
Mol Plant Pathol. 2018 May;19(5):1267-1281
pubmed: 28834153
Plant J. 2014 Sep;79(6):893-903
pubmed: 24942051
Nature. 2017 Nov 23;551(7681):498-502
pubmed: 29143815
Nat Rev Genet. 2003 Aug;4(8):626-37
pubmed: 12897774
Genome Res. 1998 Mar;8(3):175-85
pubmed: 9521921
PLoS One. 2014 Apr 09;9(4):e94171
pubmed: 24718312
Yi Chuan. 2008 Apr;30(4):491-4
pubmed: 18424421
Plant Physiol. 2007 Dec;145(4):1577-87
pubmed: 17951452
Nat Genet. 2008 Dec;40(12):1413-5
pubmed: 18978789
Nat Rev Mol Cell Biol. 2013 Mar;14(3):153-65
pubmed: 23385723
Plant Dis. 2019 Jun;103(6):1166-1171
pubmed: 30998448
Nat Immunol. 2011 Aug 18;12(9):817-26
pubmed: 21852785
Genes Dev. 2013 Nov 1;27(21):2380-96
pubmed: 24145798
Mol Plant Microbe Interact. 2008 May;21(5):507-17
pubmed: 18393610
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7940-5
pubmed: 23610408
Nat Commun. 2017 Apr 28;8:15121
pubmed: 28452349
Mol Plant Pathol. 2014 Jun;15(5):433-46
pubmed: 24373199
PLoS One. 2018 Oct 24;13(10):e0204972
pubmed: 30356268
Genome Biol. 2015 Jan 31;16:26
pubmed: 25637298
J Hered. 1946 Mar;37:81 107
pubmed: 20985728
Front Plant Sci. 2017 Jun 20;8:1057
pubmed: 28676811
Methods Mol Biol. 2003;236:3-20
pubmed: 14501055
Science. 2009 Mar 6;323(5919):1360-3
pubmed: 19229000
Science. 2017 Mar 3;355(6328):962-965
pubmed: 28154240
Food Energy Secur. 2015 Oct;4(3):178-202
pubmed: 27610232
Plant Dis. 2019 Jan;103(1):51-58
pubmed: 30387683
Plant J. 1998 May;14(3):387-92
pubmed: 9628033
Mol Genet Genomics. 2007 Mar;277(3):301-13
pubmed: 17123111
Nat Commun. 2018 Oct 3;9(1):3735
pubmed: 30282993
Plant Dis. 2012 Jan;96(1):131-140
pubmed: 30731861
Science. 2018 Aug 17;361(6403):
pubmed: 30115783
Planta. 2017 Dec;246(6):1097-1107
pubmed: 28801748
PLoS One. 2013 Oct 01;8(10):e74183
pubmed: 24098335
Science. 2009 Mar 6;323(5919):1357-60
pubmed: 19228999
Phytopathology. 2019 Jan;109(1):120-126
pubmed: 30070970
Plant J. 2014 Sep;79(6):904-13
pubmed: 24942074
Plant Mol Biol. 1992 Feb;18(4):675-89
pubmed: 1313711