Endoscopic submucosal dissection: Italian national survey on current practices, training and outcomes.


Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385

Informations de publication

Date de publication:
01 2020
Historique:
received: 29 12 2018
revised: 05 09 2019
accepted: 11 09 2019
pubmed: 21 10 2019
medline: 11 11 2020
entrez: 21 10 2019
Statut: ppublish

Résumé

Most of the evidence supporting endoscopic submucosal dissection (ESD) comes from Asia. European data are primarily reported by specialized referral centers and thus may not be representative of common European ESD practice. The aim of this study is to understand the current state of ESD practice across Italian endoscopy centers. All Italian endoscopists who were known to perform ESD were invited to complete a structured questionnaire including: operator features and competencies, ESD training details and clinical outcomes over a 2-year period. Twenty-nine operators from 23 centers (69% response rate) completed the questionnaire: 18 (62%) were <50 years old; 7 (24%) were female; 16 (70%) were located in Northern Italy. Overall ESD volume was <40 cases in 9 (31%) operators, 40-80 in 8 (27.5%), 80-150 in 4 (13.8%) and >150 in 8 (27.5%). Colorectal ESD was predominant for operators with an experience >80 cases. En-bloc resection rates ranged from 77.2 to 97.2% depending on the anatomic location with an R0 resection rate range of 75.3-93.6%. ESD perforation rates in the colon and rectum were significantly lower when experience was >150 compared to 80-150 cases (p < 0.0001 and p = 0.006 for colon and rectum, respectively). ESD in Italy is performed by a significant number of operators. Overall, Italian endoscopists performing ESD have achieved a good competence level. However, there is much variability in training protocols, initial supervision of procedures, practice settings, case mix and procedural volume/year that are likely responsible for some of the suboptimal resectional outcomes and increased perforation risk, mainly in the colon. Standardized training programs, practice parameters and auditing of outcomes are required.

Sections du résumé

BACKGROUND AND AIMS
Most of the evidence supporting endoscopic submucosal dissection (ESD) comes from Asia. European data are primarily reported by specialized referral centers and thus may not be representative of common European ESD practice. The aim of this study is to understand the current state of ESD practice across Italian endoscopy centers.
METHODS
All Italian endoscopists who were known to perform ESD were invited to complete a structured questionnaire including: operator features and competencies, ESD training details and clinical outcomes over a 2-year period.
RESULTS
Twenty-nine operators from 23 centers (69% response rate) completed the questionnaire: 18 (62%) were <50 years old; 7 (24%) were female; 16 (70%) were located in Northern Italy. Overall ESD volume was <40 cases in 9 (31%) operators, 40-80 in 8 (27.5%), 80-150 in 4 (13.8%) and >150 in 8 (27.5%). Colorectal ESD was predominant for operators with an experience >80 cases. En-bloc resection rates ranged from 77.2 to 97.2% depending on the anatomic location with an R0 resection rate range of 75.3-93.6%. ESD perforation rates in the colon and rectum were significantly lower when experience was >150 compared to 80-150 cases (p < 0.0001 and p = 0.006 for colon and rectum, respectively).
CONCLUSION
ESD in Italy is performed by a significant number of operators. Overall, Italian endoscopists performing ESD have achieved a good competence level. However, there is much variability in training protocols, initial supervision of procedures, practice settings, case mix and procedural volume/year that are likely responsible for some of the suboptimal resectional outcomes and increased perforation risk, mainly in the colon. Standardized training programs, practice parameters and auditing of outcomes are required.

Identifiants

pubmed: 31629705
pii: S1590-8658(19)30827-8
doi: 10.1016/j.dld.2019.09.009
pii:
doi:

Types de publication

Evaluation Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

64-71

Informations de copyright

Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Auteurs

Roberta Maselli (R)

Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Humanitas University, Milan, Italy. Electronic address: roberta.maselli@humanitas.it.

Federico Iacopini (F)

Gastroenterology Endoscopy Unit, S. Giuseppe Hospital, Rome, Italy.

Francesco Azzolini (F)

Division of Gastroenterology & G.I. Endoscopy, Vita Salute San Raffaele University, Milan, Italy.

Lucio Petruzziello (L)

Digestive Endoscopy Unit, Division of Gastroenterology Fondazione A. Gemelli-Università Cattolica del Sacro Cuore Hospital, IRCCS, Rome, Italy.

Mauro Manno (M)

Digestive Endoscopy Unit, USL Modena, Carpi Hospital, Italy.

Luca De Luca (L)

Division of Gastroenterology & G.I. Endoscopy, Ospedali Riuniti Marche Nord Hospital, Pesaro, Italy.

Paolo Cecinato (P)

Unit of Gastroenterology and Digestive Endoscopy, USL-IRCCS Reggio Emilia Hospital, Reggio Emilia,Italy.

Giancarla Fiori (G)

IEO, Digestive Endoscopy Unit, Istituto Europeo di Oncologia IRCCS Hospital, Milano, Italy.

Teresa Staiano (T)

Digestive Endoscopy Unit, FPO-IRCCS Candiolo Cancer Institute, Candiolo, TO, Italy.

Erik Rosa Rizzotto (E)

Division of Gastroenterology & G.I. Endoscopy, S. Antonio Hospital, Padova, Italy.

Stefano Angeletti (S)

Digestive Endoscopy Unit, Sant'Andrea Hospital, a Sapienza university, Roma, Italy.

Angelo Caruso (A)

Division of Gastroenterology & G.I. Endoscopy, Baggiovara Hospital, AOU di Modena, Italy.

Franco Coppola (F)

Digestive Endoscopy Unit, Division of Gastroenterology, ASLTO4, Turin, Italy.

Gianluca Andrisani (G)

Digestive Endoscopy Unit, Campus Biomedico Hospital, Rome, Italy.

Edi Viale (E)

Division of Gastroenterology & G.I. Endoscopy, Vita Salute San Raffaele University, Milan, Italy.

Guido Missale (G)

Digestive Endoscopy Unit, ASST Spedali Civili, Brescia University, Italy.

Alba Panarese (A)

Department of Gastroenterology and Digestive Endoscopy, National Research Institute specialized in Gastroenterology ¨S. De Bellis¨ , Castellana Grotte, BA, Italy.

Alessandro Mazzocchi (A)

Gastroenterology Endoscopy Unit, San Giovanni Battista Hospital, San Giovanni battista, Italy.

Paola Cesaro (P)

Endoscopy Unit, Fondazione Poliambulanza, Brescia, Italy.

Mariachiara Campanale (M)

Digestive Endoscopy Unit, Division of Gastroenterology Fondazione A. Gemelli-Università Cattolica del Sacro Cuore Hospital, IRCCS, Rome, Italy.

Pietro Occhipinti (P)

Division of Gastroenterology, ¨ Maggiore della CaritਠHospital and University, Novara, Italy.

Ottaviano Tarantino (O)

Division of Gastroenterology & G.I. Endoscopy, San Giuseppe Hospital, ASL Toscana centro, Empoli, Italy.

Cristiano Crosta (C)

IEO, Digestive Endoscopy Unit, Istituto Europeo di Oncologia IRCCS Hospital, Milano, Italy.

Piero Brosolo (P)

Division of Gastroenterology, Hospital of Pordenone, Pordenone, Italy.

Sandro Sferrazza (S)

Gastroenterology and Endoscopy Unit, Santa Chiara Hospital, APSS, Trento, Italy.

Emanuele Rondonotti (E)

Gastroenterology and Digestive Endoscopy Unit, Valduce Hospital, Como, Italy.

Arnaldo Amato (A)

Gastroenterology and Digestive Endoscopy Unit, Valduce Hospital, Como, Italy.

Lorenzo Fuccio (L)

Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Guido Costamagna (G)

Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy; Cattolica del Sacro CuoreUniversity, Centre for Endoscopic Research Therapeutics and Training CERTT, Roma, Italy; Université de Strasbourg Institut d'Etudes Avancées USIAS, Strasbourg, France.

Alessandro Repici (A)

Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Humanitas University, Milan, Italy; Humanitas University, Department of Biomedical Science, Milan, Italy.

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