The DNA-binding protein HTa from


Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
11 11 2019
Historique:
received: 07 10 2019
accepted: 10 11 2019
pubmed: 12 11 2019
medline: 12 5 2020
entrez: 12 11 2019
Statut: epublish

Résumé

Histones are a principal constituent of chromatin in eukaryotes and fundamental to our understanding of eukaryotic gene regulation. In archaea, histones are widespread but not universal: several lineages have lost histone genes. What prompted or facilitated these losses and how archaea without histones organize their chromatin remains largely unknown. Here, we elucidate primary chromatin architecture in an archaeon without histones,

Identifiants

pubmed: 31710291
doi: 10.7554/eLife.52542
pii: 52542
pmc: PMC6877293
doi:
pii:

Substances chimiques

Archaeal Proteins 0
Chromatin 0
DNA-Binding Proteins 0
Histones 0

Banques de données

GEO
['GSE127728', 'GSE127678']
SRA
['SRR495445', 'SRR574592']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MC_UP_1102/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_A658_5TY40
Pays : United Kingdom

Informations de copyright

© 2019, Hocher et al.

Déclaration de conflit d'intérêts

AH, MR, JS, AE, TW No competing interests declared

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Auteurs

Antoine Hocher (A)

MRC London Institute of Medical Sciences (LMS), London, United Kingdom.
Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College, London, United Kingdom.

Maria Rojec (M)

MRC London Institute of Medical Sciences (LMS), London, United Kingdom.
Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College, London, United Kingdom.

Jacob B Swadling (JB)

MRC London Institute of Medical Sciences (LMS), London, United Kingdom.
Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College, London, United Kingdom.

Alexander Esin (A)

MRC London Institute of Medical Sciences (LMS), London, United Kingdom.
Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College, London, United Kingdom.

Tobias Warnecke (T)

MRC London Institute of Medical Sciences (LMS), London, United Kingdom.
Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College, London, United Kingdom.

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Classifications MeSH