Contribution of proteasome-catalyzed peptide
AIDS Vaccines
/ immunology
Antigens, Viral
/ genetics
CD8-Positive T-Lymphocytes
/ immunology
Cell Line
Cohort Studies
Cross Reactions
/ immunology
Cross-Priming
/ genetics
Datasets as Topic
Epitopes, T-Lymphocyte
/ genetics
HIV Infections
/ blood
HIV-1
/ genetics
Histocompatibility Antigens Class I
/ immunology
Humans
Immune Evasion
Peptides
/ genetics
Proteasome Endopeptidase Complex
/ immunology
RNA Splicing
/ immunology
RNA, Viral
/ blood
RNA-Seq
Viral Proteins
/ genetics
T cell epitope
human immunodeficiency virus
immunopeptidome
peptide splicing
proteasome
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
pubmed:
22
11
2019
medline:
14
4
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Peptides generated by proteasome-catalyzed splicing of noncontiguous amino acid sequences have been shown to constitute a source of nontemplated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8
Identifiants
pubmed: 31748275
pii: 1911622116
doi: 10.1073/pnas.1911622116
pmc: PMC6900506
doi:
Substances chimiques
AIDS Vaccines
0
Antigens, Viral
0
Epitopes, T-Lymphocyte
0
Histocompatibility Antigens Class I
0
Peptides
0
RNA, Viral
0
Viral Proteins
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24748-24759Subventions
Organisme : Medical Research Council
ID : MC_UU_12009
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 097813/Z/11/B#
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M00919X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K012037
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118549
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI144371
Pays : United States
Organisme : Medical Research Council
ID : G0902418
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K012037/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : UM1 AI100645
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12025
Pays : United Kingdom
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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