A comparative genomics study of 23 Aspergillus species from section Flavi.

Aspergillus flavus / classification Aspergillus oryzae / classification Bioreactors Carbohydrate Metabolism / genetics Crops, Agricultural / microbiology DNA, Fungal / genetics Fermentation Fermented Foods Fungal Proteins / genetics Genome, Fungal / genetics Genomics Metabolic Networks and Pathways / genetics Multigene Family Phenotype Phylogeny Plant Diseases / prevention & control Secondary Metabolism / genetics

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
27 02 2020

Historique:

received: 16 04 2019

accepted: 02 12 2019

entrez: 29 2 2020

pubmed: 29 2 2020

medline: 6 5 2020

Statut: epublish

Résumé

Section Flavi encompasses both harmful and beneficial Aspergillus species, such as Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food spoiler and mycotoxin producer. Here, we sequence 19 genomes spanning section Flavi and compare 31 fungal genomes including 23 Flavi species. We reassess their phylogenetic relationships and show that the closest relative of A. oryzae is not A. flavus, but A. minisclerotigenes or A. aflatoxiformans and identify high genome diversity, especially in sub-telomeric regions. We predict abundant CAZymes (598 per species) and prolific secondary metabolite gene clusters (73 per species) in section Flavi. However, the observed phenotypes (growth characteristics, polysaccharide degradation) do not necessarily correlate with inferences made from the predicted CAZyme content. Our work, including genomic analyses, phenotypic assays, and identification of secondary metabolites, highlights the genetic and metabolic diversity within section Flavi.

Identifiants

DOI: 10.1038/s41467-019-14051-y PMID: 32107379 PMC: PMC7046712

pubmed: 32107379

doi: 10.1038/s41467-019-14051-y

pii: 10.1038/s41467-019-14051-y

pmc: PMC7046712

doi:

Substances chimiques

DNA, Fungal 0

Fungal Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

Pagination

1106

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