Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
06
02
2020
accepted:
14
02
2020
revised:
13
02
2020
pubmed:
7
3
2020
medline:
29
12
2020
entrez:
7
3
2020
Statut:
ppublish
Résumé
We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibitor. The biosynthetic gene cluster consisted of four genes, one of which was involved in conferring self-resistance to 1233A.
Identifiants
pubmed: 32139880
doi: 10.1038/s41429-020-0295-4
pii: 10.1038/s41429-020-0295-4
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Furans
0
Lactones
0
Naphthoquinones
0
Pyrroles
0
fusarubin
0
lucilactaene
0
antibiotic 1233A
29066-42-0
Hygromycin B
3XQ2233B0B
Hydroxymethylglutaryl-CoA Synthase
EC 2.3.3.10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
475-479Références
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