GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope.
Clone Cells
Combinatorial Chemistry Techniques
Computational Biology
Cross Reactions
Epitope Mapping
Epitopes, T-Lymphocyte
/ genetics
High-Throughput Nucleotide Sequencing
Host-Pathogen Interactions
Insulin
/ immunology
Molecular Mimicry
Pathogen-Associated Molecular Pattern Molecules
/ immunology
Peptide Library
Receptors, Antigen, T-Cell
/ metabolism
T-Cell Antigen Receptor Specificity
T-Lymphocytes
/ immunology
Compute Unified Device Architecture (CUDA)
Nvidia
T-cell receptor
general-purpose computing on graphics processing units (GP-GPU)
insulin
molecular mimicry
peptide-HLA
type 1 diabetes
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
09
2019
accepted:
05
02
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
5
3
2021
Statut:
epublish
Résumé
The strong links between (Human Leukocyte Antigen) HLA, infection and autoimmunity combine to implicate T-cells as primary triggers of autoimmune disease (AD). T-cell crossreactivity between microbially-derived peptides and self-peptides has been shown to break tolerance and trigger AD in experimental animal models. Detailed examination of the potential for T-cell crossreactivity to trigger human AD will require means of predicting which peptides might be recognised by autoimmune T-cell receptors (TCRs). Recent developments in high throughput sequencing and bioinformatics mean that it is now possible to link individual TCRs to specific pathologies for the first time. Deconvolution of TCR function requires knowledge of TCR specificity. Positional Scanning Combinatorial Peptide Libraries (PS-CPLs) can be used to predict HLA-restriction and define antigenic peptides derived from self and pathogen proteins.
Identifiants
pubmed: 32184781
doi: 10.3389/fimmu.2020.00296
pmc: PMC7058665
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Insulin
0
Pathogen-Associated Molecular Pattern Molecules
0
Peptide Library
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
296Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT100327MA
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H001085/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Whalley, Dolton, Brown, Wall, Wooldridge, van den Berg, Fuller, Hopkins, Crowther, Attaf, Knight, Cole, Peakman, Sewell and Szomolay.
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