Myeloid ALX/FPR2 regulates vascularization following tissue injury.
Animals
Cells, Cultured
Disease Models, Animal
Docosahexaenoic Acids
/ metabolism
Female
Gene Knockout Techniques
Humans
Ischemia
/ immunology
Macrophages
/ immunology
Male
Mice
Mice, Knockout
Muscle, Skeletal
/ blood supply
Neovascularization, Physiologic
/ immunology
Primary Cell Culture
RNA-Seq
Receptors, Formyl Peptide
/ genetics
Receptors, Lipoxin
/ genetics
Signal Transduction
/ immunology
Skin
/ blood supply
Transcription, Genetic
/ immunology
Wound Healing
/ immunology
ischemia
macrophages
resolvins
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
pubmed:
10
6
2020
medline:
29
8
2020
entrez:
10
6
2020
Statut:
ppublish
Résumé
Ischemic injury initiates a sterile inflammatory response that ultimately participates in the repair and recovery of tissue perfusion. Macrophages are required for perfusion recovery during ischemia, in part because they produce growth factors that aid in vascular remodeling. The input signals governing this pro-revascularization phenotype remain of interest. Here we found that hindlimb ischemia increases levels of resolvin D1 (RvD1), an inflammation-resolving lipid mediator that targets macrophages via its receptor, ALX/FPR2. Exogenous RvD1 enhances perfusion recovery during ischemia, and mice deficient in
Identifiants
pubmed: 32513697
pii: 1918163117
doi: 10.1073/pnas.1918163117
pmc: PMC7321964
doi:
Substances chimiques
FPR2 protein, human
0
Receptors, Formyl Peptide
0
Receptors, Lipoxin
0
formyl peptide receptor 2, mouse
0
resolvin D1
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14354-14364Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM095467
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124782
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL106173
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18232-7
pubmed: 24108355
J Exp Med. 1994 Jul 1;180(1):253-60
pubmed: 8006586
Circ Res. 2004 Mar 19;94(5):671-7
pubmed: 14963007
Nat Protoc. 2009;4(12):1737-46
pubmed: 19893509
Circulation. 2016 Aug 30;134(9):666-680
pubmed: 27507404
Int Immunopharmacol. 2015 Sep;28(1):322-7
pubmed: 26118631
Pharmacol Rev. 2009 Jun;61(2):119-61
pubmed: 19498085
Methods Mol Biol. 2018;1730:59-72
pubmed: 29363065
Nat Immunol. 2019 May;20(5):626-636
pubmed: 30936495
FASEB J. 2007 Feb;21(2):325-32
pubmed: 17267386
Circ Res. 2015 Jan 16;116(2):307-11
pubmed: 25593275
Diabetes. 2013 Feb;62(2):618-27
pubmed: 23043160
Am J Pathol. 2010 Oct;177(4):2116-23
pubmed: 20709806
Circ Res. 2019 Apr 12;124(8):1166-1168
pubmed: 30973815
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
Science. 2017 Jun 9;356(6342):1026-1030
pubmed: 28596335
Surgery. 2010 Aug;148(2):436-43
pubmed: 20434187
Circulation. 2016 May 31;133(22):2169-79
pubmed: 27154726
Curr Protoc Immunol. 2008 Nov;Chapter 14:Unit 14.1
pubmed: 19016445
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):594-602
pubmed: 24407030
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1970-8
pubmed: 22499990
J Immunol. 2011 Nov 15;187(10):5408-18
pubmed: 22013115
Circ Res. 2015 Apr 24;116(9):1561-78
pubmed: 25908729
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5
pubmed: 20080636
JCI Insight. 2016 Apr 21;1(5):e85922
pubmed: 27158677
Am J Pathol. 2012 May;180(5):2018-27
pubmed: 22449948
PLoS One. 2012;7(9):e43568
pubmed: 23049737
Development. 2013 Apr;140(8):1720-9
pubmed: 23533173
J Mol Cell Cardiol. 2015 Jul;84:24-35
pubmed: 25870158
J Immunol. 2008 Dec 15;181(12):8677-87
pubmed: 19050288
Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L888-901
pubmed: 26301452
EMBO J. 2018 Jul 2;37(13):
pubmed: 29866703
J Exp Med. 2000 Apr 3;191(7):1197-208
pubmed: 10748237
J Leukoc Biol. 2018 Jan 29;:
pubmed: 29377345
Circ Res. 2015 Apr 24;116(9):1509-26
pubmed: 25908725
Nat Commun. 2016 Sep 23;7:12859
pubmed: 27659679
J Exp Med. 2002 Oct 21;196(8):1025-37
pubmed: 12391014
Immunity. 2019 May 21;50(5):1149-1162
pubmed: 31117011
PLoS One. 2013 Jul 24;8(7):e68811
pubmed: 23894348
J Clin Invest. 2018 Jul 2;128(7):2657-2669
pubmed: 29757195
J Clin Invest. 2017 Jan 3;127(1):83-93
pubmed: 28045401
Blood. 2012 Oct 11;120(15):e60-72
pubmed: 22904297
J Immunol. 2018 Apr 15;200(8):2757-2766
pubmed: 29523657
JAAPA. 2018 Aug;31(8):1-5
pubmed: 30048362
Methods Mol Biol. 2017;1668:93-103
pubmed: 28842904
Innate Immun. 2016 Apr;22(3):186-95
pubmed: 26878867
Science. 2013 Jan 11;339(6116):161-6
pubmed: 23307733
Science. 2013 Jan 11;339(6116):166-72
pubmed: 23307734
Nat Med. 2007 Jul;13(7):868-873
pubmed: 17589522
J Immunol. 2016 Jun 1;196(11):4771-82
pubmed: 27183604
PLoS One. 2014 Sep 09;9(9):e106987
pubmed: 25202910
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4743-52
pubmed: 19407006
J Biol Chem. 2007 Mar 30;282(13):9323-34
pubmed: 17244615
J Invest Dermatol. 2018 Sep;138(9):2051-2060
pubmed: 29559341
J Vasc Surg. 2018 Dec;68(6S):188S-200S.e4
pubmed: 30064835
J Cardiovasc Pharmacol. 2015 Jul;66(1):72-9
pubmed: 25806690