Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways.
ADAMTS1 Protein
/ metabolism
Animals
Animals, Suckling
Association Learning
/ physiology
Cerebral Cortex
/ metabolism
Complement Activation
Complement C5a
/ physiology
Cronobacter sakazakii
/ pathogenicity
Enterobacteriaceae Infections
/ complications
Escherichia coli Infections
/ complications
Gene Expression Regulation
/ immunology
Inflammation
Interferon-alpha
/ metabolism
Interleukin-6
/ metabolism
Janus Kinases
/ metabolism
Learning Disabilities
/ etiology
MAP Kinase Kinase Kinase 1
/ metabolism
MAP Kinase Kinase Kinase 5
/ physiology
Memory Disorders
/ etiology
NF-kappa B
/ physiology
Nerve Tissue Proteins
/ biosynthesis
Proto-Oncogene Proteins c-akt
/ metabolism
Rats
Serotonin
/ metabolism
Serotonin Plasma Membrane Transport Proteins
/ metabolism
Signal Transduction
/ physiology
ADAMTS
Contextual-associated learning
Cronobacter sakazakii
IL-6
NF-κB
SERT
Sepsis
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
17
10
2019
accepted:
08
06
2020
pubmed:
23
6
2020
medline:
28
8
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
This study was designed to test whether the Cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat pups (postnatal day, PND 15) were treated with either C. sakazakii (10
Identifiants
pubmed: 32567007
doi: 10.1007/s12031-020-01622-8
pii: 10.1007/s12031-020-01622-8
doi:
Substances chimiques
Il6 protein, rat
0
Interferon-alpha
0
Interleukin-6
0
NF-kappa B
0
Nerve Tissue Proteins
0
Serotonin Plasma Membrane Transport Proteins
0
Slc6a4 protein, rat
0
Serotonin
333DO1RDJY
Complement C5a
80295-54-1
Janus Kinases
EC 2.7.10.2
Akt3 protein, rat
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
MAP Kinase Kinase Kinase 1
EC 2.7.11.25
MAP Kinase Kinase Kinase 5
EC 2.7.11.25
ADAMTS1 Protein
EC 3.4.24.-
Adamts1 protein, rat
EC 3.4.24.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-41Subventions
Organisme : Department of Biotechnology , Ministry of Science and Technology
ID : BT/PR17367/MED/122/44/2016
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