PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions.
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
18 09 2020
18 09 2020
Historique:
pubmed:
18
8
2020
medline:
9
6
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of methods for the analysis of small molecule-RNA interactions. Here, we present our efforts to develop such a platform using photoaffinity labeling. This technique, termed
Identifiants
pubmed: 32804474
doi: 10.1021/acschembio.0c00357
doi:
Substances chimiques
Aptamers, Nucleotide
0
Azides
0
Ligands
0
Photoaffinity Labels
0
Diazomethane
60A625P70P
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM