Beyond Toxin Transport: Novel Role of ABC Transporter for Enzymatic Machinery of Cereulide NRPS Assembly Line.

ATP-Binding Cassette Transporters / genetics Bacillus cereus / enzymology Depsipeptides / metabolism Genes, Bacterial Multigene Family Peptide Biosynthesis, Nucleic Acid-Independent Peptide Synthases / genetics Secondary Metabolism
ABC transporter Bacillus cereus bacterial adenylate cyclase-based two-hybrid system (BACTH) cereulide nonribosomal peptide synthetases (NRPS)

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
29 09 2020
Historique:
entrez: 30 9 2020
pubmed: 1 10 2020
medline: 21 7 2021
Statut: epublish

Résumé

Nonribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs) play a pivotal role in the production of bioactive natural products, such as antibiotics and cytotoxins. Despite biomedical and pharmaceutical importance, the molecular mechanisms and architectures of these multimodular enzyme complexes are not fully understood. Here, we report on an ABC transporter that forms a vital part of the nonribosomal peptide biosynthetic machinery. Emetic

Identifiants

DOI: 10.1128/mBio.01577-20 PMID: 32994334 PMC: PMC7527721
pubmed: 32994334
pii: mBio.01577-20
doi: 10.1128/mBio.01577-20
pmc: PMC7527721
pii:
doi:

Substances chimiques

ATP-Binding Cassette Transporters 0
Depsipeptides 0
cereulide 0
Peptide Synthases EC 6.3.2.-
non-ribosomal peptide synthase EC 6.3.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 Gacek-Matthews et al.

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Auteurs

A Gacek-Matthews (A)

Institute of Microbiology, Vetmeduni Vienna, Vienna, Austria.
ORCID: 0000-0001-5884-583X

Z Chromiková (Z)

Institute of Microbiology, Vetmeduni Vienna, Vienna, Austria.
Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia.

M Sulyok (M)

Institute for Bioanalytics and Agro-Metabolomics, Department IFA-Tulln, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria.

G Lücking (G)

ZIEL Institute for Food and Health, Technische Universität München, Freising, Germany.

I Barák (I)

Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia imrich.barak@savba.sk monika.ehling-schulz@vetmeduni.ac.at.

M Ehling-Schulz (M)

Institute of Microbiology, Vetmeduni Vienna, Vienna, Austria imrich.barak@savba.sk monika.ehling-schulz@vetmeduni.ac.at.
ORCID: 0000-0001-7384-0594

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Bacillus cereus › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Depsipeptides › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Gènes bactériens › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Métabolisme › Biosynthèse des peptides › Biosynthèse non ribosomique des peptides › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Beyond Toxin Transport: Novel Role of ABC...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Métabolisme secondaire › Beyond Toxin Transport: Novel Role of ABC...