Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster.

Arginine / analogs & derivatives Bacterial Proteins / genetics Biosynthetic Pathways Genomics Metabolomics Multigene Family Peptide Synthases / genetics Streptomyces / genetics

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
20 11 2020
Historique:
pubmed: 6 11 2020
medline: 28 5 2021
entrez: 5 11 2020
Statut: ppublish

Résumé

We report the metabolomics-driven genome mining of a new cyclic-guanidino incorporating non-ribosomal peptide synthetase (NRPS) gene cluster and full structure elucidation of its associated hexapeptide product, faulknamycin. Structural studies unveiled that this natural product contained the previously unknown (

Identifiants

DOI: 10.1021/acschembio.0c00663 PMID: 33151679 PMC: PMC7830813
pubmed: 33151679
doi: 10.1021/acschembio.0c00663
pmc: PMC7830813
mid: NIHMS1662462
doi:

Substances chimiques

Bacterial Proteins 0
capreomycidine 0
Arginine 94ZLA3W45F
Peptide Synthases EC 6.3.2.-
non-ribosomal peptide synthase EC 6.3.2.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

3013-3020

Subventions

Organisme : NCCIH NIH HHS
ID : R01 AT009143
Pays : United States

Références

ACS Chem Biol. 2018 Nov 16;13(11):3097-3106
pubmed: 30272441
Nat Chem Biol. 2020 Jan;16(1):60-68
pubmed: 31768033
J Ind Microbiol Biotechnol. 2014 Feb;41(2):175-84
pubmed: 24342967
J Am Chem Soc. 2016 Nov 23;138(46):15157-15166
pubmed: 27797509
Adv Mater. 2016 Dec;28(48):10630-10636
pubmed: 27862402
Nature. 2002 May 9;417(6885):141-7
pubmed: 12000953
Chembiochem. 2004 Sep 6;5(9):1278-81
pubmed: 15368581
Angew Chem Int Ed Engl. 2018 Jun 4;57(23):6780-6785
pubmed: 29633497
Nucleic Acids Res. 2019 Jul 2;47(W1):W81-W87
pubmed: 31032519
ACS Chem Biol. 2016 Dec 16;11(12):3452-3460
pubmed: 27809474
Nature. 1971 Jun 4;231(5301):301-2
pubmed: 4325287
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12175-80
pubmed: 26324907
J Antibiot (Tokyo). 2005 Jan;58(1):1-26
pubmed: 15813176
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5391-3
pubmed: 8390660
J Ind Microbiol Biotechnol. 2006 Jul;33(7):507-13
pubmed: 16418869
Genome Res. 2005 Jun;15(6):820-9
pubmed: 15930493
Nat Chem Biol. 2014 Nov;10(11):963-8
pubmed: 25262415
Experientia. 1971 May 15;27(5):501-3
pubmed: 4332116
Genome Biol. 2016 Nov 25;17(1):239
pubmed: 27887629
Appl Environ Microbiol. 2007 Jul;73(13):4162-70
pubmed: 17496129
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83
pubmed: 10811905
J Antibiot (Tokyo). 1973 Nov;26(11):625-46
pubmed: 4792111
EcoSal Plus. 2016 May;7(1):
pubmed: 27223821
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15748-53
pubmed: 14673109
ACS Chem Biol. 2019 May 17;14(5):845-849
pubmed: 30925045
Bioinformatics. 2017 Oct 15;33(20):3202-3210
pubmed: 28633438
ACS Chem Biol. 2018 Apr 20;13(4):1029-1037
pubmed: 29510029
ACS Cent Sci. 2016 Feb 24;2(2):99-108
pubmed: 27163034
J Comput Biol. 2012 May;19(5):455-77
pubmed: 22506599
J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):155-76
pubmed: 26739136
ChemMedChem. 2012 Jul;7(7):1237-44
pubmed: 22639134
Nat Prod Rep. 2016 Aug 27;33(8):988-1005
pubmed: 27272205
J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):281-299
pubmed: 30484124
Chem Pharm Bull (Tokyo). 2018;66(2):123-131
pubmed: 29386462

Auteurs

James H Tryon (JH)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

Jennifer C Rote (JC)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

Li Chen (L)

Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States.

Matthew T Robey (MT)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

Marvin M Vega (MM)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

Wan Cheng Phua (WC)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

William W Metcalf (WW)

Carl R. Woese Institute for Genomic Biology and The Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
ORCID: 0000-0002-0182-0671

Kou-San Ju (KS)

Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States.
The Division of Medicinal Chemistry and Pharmacognosy, Center for Applied Plant Sciences, and Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210, United States.
ORCID: 0000-0003-0438-6740

Neil L Kelleher (NL)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
ORCID: 0000-0002-8815-3372

Regan J Thomson (RJ)

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
ORCID: 0000-0001-5546-4038

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Arginine › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Genome Mining and Metabolomics Uncover a Rare...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Genome Mining and Metabolomics Uncover a Rare...