Anti-tumour immunity induces aberrant peptide presentation in melanoma.
Antigen Presentation
Cell Line
Codon
/ genetics
Frameshift Mutation
Frameshifting, Ribosomal
/ drug effects
Histocompatibility Antigens Class I
/ immunology
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
/ antagonists & inhibitors
Interferon-gamma
/ immunology
Melanoma
/ immunology
Peptides
/ chemistry
Protein Biosynthesis
/ drug effects
Proteome
Ribosomes
/ drug effects
T-Lymphocytes
/ immunology
Tryptophan
/ deficiency
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
09
01
2020
accepted:
30
10
2020
pubmed:
18
12
2020
medline:
10
3
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
Extensive tumour inflammation, which is reflected by high levels of infiltrating T cells and interferon-γ (IFNγ) signalling, improves the response of patients with melanoma to checkpoint immunotherapy
Identifiants
pubmed: 33328638
doi: 10.1038/s41586-020-03054-1
pii: 10.1038/s41586-020-03054-1
doi:
Substances chimiques
Codon
0
Histocompatibility Antigens Class I
0
IDO1 protein, human
0
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
Peptides
0
Proteome
0
Interferon-gamma
82115-62-6
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-337Subventions
Organisme : European Research Council
Pays : International
Commentaires et corrections
Type : CommentIn
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