Ion mobility-high resolution mass spectrometry in anti-doping analysis. Part I: Implementation of a screening method with the assessment of a library of substances prohibited in sports.

Anabolic Agents Chromatography, High Pressure Liquid Doping in Sports Ion Mobility Spectrometry Mass Spectrometry Substance Abuse Detection
Collision cross section Doping analysis High resolution mass spectrometry Ion mobility spectrometry Ultra-high performance liquid chromatography

Journal

Analytica chimica acta
ISSN: 1873-4324
Titre abrégé: Anal Chim Acta
Pays: Netherlands
ID NLM: 0370534

Informations de publication

Date de publication:
01 Apr 2021
Historique:
received: 23 09 2020
revised: 22 01 2021
accepted: 25 01 2021
entrez: 2 3 2021
pubmed: 3 3 2021
medline: 15 5 2021
Statut: ppublish

Résumé

In this series of two papers, 192 doping agents belonging to the classes of stimulants, narcotics, cannabinoids, diuretics, β2-agonists, β-blockers, anabolic agents, and hormone and metabolic modulators were investigated, with the aim to assess the benefits and limitations of ion mobility spectrometry (IMS) in combination with ultra-high performance liquid chromatography (UHPLC) and high resolution mass spectrometry (HRMS) in anti-doping analysis. In this first part, a generic UHPLC-IM-HRMS method was successfully developed to analyze these 192 doping agents in standard solutions and urine samples, and an exhaustive database including retention times,

Identifiants

DOI: 10.1016/j.aca.2021.338257 PMID: 33648637
pubmed: 33648637
pii: S0003-2670(21)00083-0
doi: 10.1016/j.aca.2021.338257
pii:
doi:

Substances chimiques

Anabolic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

338257

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Kateřina Plachká (K)

Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.

Julian Pezzatti (J)

School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland.

Alessandro Musenga (A)

Swiss Laboratory for Doping Analyses, University Center of Legal Medicine Lausanne and Geneva, Lausanne University Hospital and University of Lausanne, Switzerland.

Raul Nicoli (R)

Swiss Laboratory for Doping Analyses, University Center of Legal Medicine Lausanne and Geneva, Lausanne University Hospital and University of Lausanne, Switzerland.

Tiia Kuuranne (T)

Swiss Laboratory for Doping Analyses, University Center of Legal Medicine Lausanne and Geneva, Lausanne University Hospital and University of Lausanne, Switzerland.

Serge Rudaz (S)

School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland.

Lucie Nováková (L)

Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.

Davy Guillarme (D)

School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland. Electronic address: Davy.Guillarme@unige.ch.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Anabolisants › Ion mobility-high resolution mass spectrometry...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Ion mobility-high resolution mass spectrometry...
questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Dopage sportif › Ion mobility-high resolution mass spectrometry...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrométrie de mobilité ionique › Ion mobility-high resolution mass spectrometry...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Ion mobility-high resolution mass spectrometry...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Détection d'abus de substances › Ion mobility-high resolution mass spectrometry...