Terminally Differentiated CD4
Aging
/ genetics
Animals
CD4-Positive T-Lymphocytes
/ immunology
Cell Differentiation
/ genetics
Cells, Cultured
Gene Expression
/ immunology
HLA-DRB1 Chains
/ genetics
Heart Diseases
/ genetics
Humans
Immunologic Memory
/ genetics
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Mice, Transgenic
Myocardium
/ immunology
RNA-Seq
/ methods
Transplantation, Heterologous
CD4+ T-cells
NSG animals
immunosenescence
inflammaging
lymphocytes
myocardial aging
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
07
2020
accepted:
04
01
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
29
6
2021
Statut:
epublish
Résumé
The cardiovascular and immune systems undergo profound and intertwined alterations with aging. Recent studies have reported that an accumulation of memory and terminally differentiated T cells in elderly subjects can fuel myocardial aging and boost the progression of heart diseases. Nevertheless, it remains unclear whether the immunological senescence profile is sufficient to cause age-related cardiac deterioration or merely acts as an amplifier of previous tissue-intrinsic damage. Herein, we sought to decompose the causality in this cardio-immune crosstalk by studying young mice harboring a senescent-like expanded CD4
Identifiants
pubmed: 33679735
doi: 10.3389/fimmu.2021.584538
pmc: PMC7935504
doi:
Substances chimiques
HLA-DRB1 Chains
0
HLA-DRB1*01:01 antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
584538Informations de copyright
Copyright © 2021 Delgobo, Heinrichs, Hapke, Ashour, Appel, Srivastava, Heckel, Spyridopoulos, Hofmann, Frantz and Ramos.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Clin Immunol. 2018 Jul;192:20-29
pubmed: 29608971
Nat Rev Immunol. 2009 Apr;9(4):271-85
pubmed: 19319144
Front Pharmacol. 2017 Jun 13;8:363
pubmed: 28659798
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W193-200
pubmed: 17478515
Physiology (Bethesda). 2013 Nov;28(6):391-403
pubmed: 24186934
JCI Insight. 2019 Nov 14;4(22):
pubmed: 31723062
Cell Mol Immunol. 2016 Sep;13(5):669-77
pubmed: 26189367
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65
pubmed: 15972602
J Virol. 2018 Mar 14;92(7):
pubmed: 29343582
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2420-E2429
pubmed: 28255084
Cell Mol Immunol. 2020 Jan;17(1):27-35
pubmed: 31853000
J Immunol. 2005 May 15;174(10):6039-44
pubmed: 15879097
Exp Gerontol. 2014 Jun;54:1-5
pubmed: 24291068
JCI Insight. 2016 Jul 21;1(11):e87680
pubmed: 27699223
Ecol Lett. 2019 Oct;22(10):1709-1722
pubmed: 31321874
Nat Immunol. 2011 Jun;12(6):492-9
pubmed: 21739672
Circ Res. 2018 Sep 14;123(7):773-786
pubmed: 30355081
Dev Reprod. 2019 Jun;23(2):79-92
pubmed: 31321348
Aging Cell. 2016 Apr;15(2):389-92
pubmed: 26696322
Sci Rep. 2019 Mar 1;9(1):3304
pubmed: 30824797
J Immunol. 2005 May 15;174(10):6477-89
pubmed: 15879151
J Mol Cell Cardiol. 2016 Apr;93:175-85
pubmed: 26578393
J Clin Invest. 2011 Aug;121(8):3109-19
pubmed: 21785218
Immunity. 2018 Feb 20;48(2):214-226
pubmed: 29466754
Lab Invest. 2020 Jan;100(1):27-37
pubmed: 31409886
Nature. 2020 Jul;583(7817):590-595
pubmed: 32669714
Circ Res. 2020 Sep 25;127(8):1115-1117
pubmed: 32806992
J Clin Invest. 2016 Dec 1;126(12):4626-4639
pubmed: 27820698
Science. 2019 Nov 15;366(6467):881-886
pubmed: 31727837
NPJ Genom Med. 2019 Sep 20;4:23
pubmed: 31552141
FASEB J. 2019 Mar;33(3):3137-3151
pubmed: 30383447
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Med. 2019 Mar;25(3):487-495
pubmed: 30842675
BMC Bioinformatics. 2018 Oct 4;19(1):366
pubmed: 30286710
Mech Ageing Dev. 1998 May 15;102(2-3):187-98
pubmed: 9720651
NPJ Aging Mech Dis. 2020 Jan 21;6:3
pubmed: 31993214
Immunity. 2013 Jan 24;38(1):187-97
pubmed: 23260195
Cell Metab. 2014 Oct 7;20(4):555-7
pubmed: 25295782
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13306-11
pubmed: 10557316
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1883-1888
pubmed: 29432166
JAMA Cardiol. 2019 Jan 1;4(1):25-33
pubmed: 30566180
Bioinformatics. 2009 Apr 1;25(7):875-81
pubmed: 19189975
N Engl J Med. 2017 Jul 13;377(2):111-121
pubmed: 28636844
J Clin Invest. 2019 Aug 13;129(11):4922-4936
pubmed: 31408441
Front Immunol. 2019 Jul 10;10:1614
pubmed: 31354744
Sci Adv. 2019 Aug 21;5(8):eaaw8330
pubmed: 31457092
Mech Ageing Dev. 2020 Oct;191:111351
pubmed: 32910956
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
J Exp Med. 2006 Jul 10;203(7):1701-11
pubmed: 16818678
J Immunol. 2008 Mar 15;180(6):3910-8
pubmed: 18322199
Mol Cell. 2018 Sep 20;71(6):882-895
pubmed: 30241605
J Immunol. 2013 Aug 15;191(4):1753-64
pubmed: 23833235
Immun Ageing. 2019 Sep 11;16:24
pubmed: 31528179
Science. 2020 Jun 19;368(6497):1371-1376
pubmed: 32439659
Nature. 2019 Jul;571(7764):205-210
pubmed: 31270459
Aging Cell. 2019 Oct;18(5):e13015
pubmed: 31353772
NPJ Aging Mech Dis. 2015 Sep 28;1:15005
pubmed: 28721254