The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia.


Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
11 05 2021
Historique:
entrez: 12 5 2021
pubmed: 13 5 2021
medline: 25 5 2021
Statut: epublish

Résumé

The spike (S) polypeptide of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) consists of the S1 and S2 subunits and is processed by cellular proteases at the S1/S2 boundary that contains a furin cleavage site (FCS),

Identifiants

pubmed: 33975939
pii: mBio.01006-21
doi: 10.1128/mBio.01006-21
pmc: PMC8262919
pii:
doi:

Substances chimiques

Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0
Furin EC 3.4.21.75

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK054759
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150877
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139365
Pays : United States

Informations de copyright

Copyright © 2021 Zou et al.

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Auteurs

Wei Zou (W)

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.

Min Xiong (M)

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Siyuan Hao (S)

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Elizabeth Yan Zhang (EY)

GeneGoCell Inc., San Diego, California, USA.

Nathalie Baumlin (N)

Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Michael D Kim (MD)

Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Matthias Salathe (M)

Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Ziying Yan (Z)

Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA ziying-yan@uiowa.edu jqiu@kumc.edu.

Jianming Qiu (J)

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA ziying-yan@uiowa.edu jqiu@kumc.edu.

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