Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.
Adenocarcinoma
/ genetics
Adenosylhomocysteinase
/ genetics
Biomarkers, Tumor
/ genetics
Gene Dosage
Gene Expression Profiling
/ methods
Gene Expression Regulation, Neoplastic
High-Throughput Nucleotide Sequencing
Humans
Methionine
/ metabolism
Methionine Adenosyltransferase
/ genetics
Mortality
Mutation
Prognosis
Sequence Analysis, RNA
Single-Cell Analysis
Stomach Neoplasms
/ genetics
Survival Analysis
Exome Sequencing
/ methods
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
25
12
2020
accepted:
21
07
2021
revised:
19
07
2021
pubmed:
31
7
2021
medline:
31
12
2021
entrez:
30
7
2021
Statut:
ppublish
Résumé
Hepatoid adenocarcinoma of the stomach (HAS), a rare subtype of gastric cancer (GC), has a low incidence but a high mortality rate. Little is known about the molecular features of HAS. Here we applied whole-exome sequencing (WES) on 58 tumours and the matched normal controls from 54 HAS patients, transcriptome sequencing on 30 HAS tumours, and single-cell RNA sequencing (scRNA-seq) on one HAS tumour. Our results reveal that the adenocarcinomatous component and hepatocellular-like component of the same HAS tumour originate monoclonally, and HAS is likely to initiate from pluripotent precursor cells. HAS has high stemness and high methionine cycle activity compared to classical GC. Two genes in the methionine cycle, MAT2A, and AHCY are potential targets for HAS treatments. We provide the first integrative genomic profiles of HAS, which may facilitate its diagnosis, prognosis, and treatment.
Identifiants
pubmed: 34326469
doi: 10.1038/s41388-021-01976-2
pii: 10.1038/s41388-021-01976-2
doi:
Substances chimiques
Biomarkers, Tumor
0
Methionine
AE28F7PNPL
MAT2A protein, human
EC 2.5.1.6
Methionine Adenosyltransferase
EC 2.5.1.6
AHCY protein, human
EC 3.3.1.1
Adenosylhomocysteinase
EC 3.3.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5705-5717Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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