Intrathymic differentiation of natural antibody-producing plasma cells in human neonates.
Adult
Antigens, CD
/ metabolism
B-Lymphocytes
/ cytology
Cell Differentiation
Fetal Blood
/ cytology
Gene Expression Profiling
Humans
Immunity, Innate
Immunoglobulin G
/ metabolism
Immunoglobulin Heavy Chains
/ immunology
Immunoglobulin Variable Region
/ immunology
Infant, Newborn
Lymphocyte Subsets
/ cytology
Plasma Cells
/ cytology
Principal Component Analysis
RNA-Seq
Single-Cell Analysis
Somatic Hypermutation, Immunoglobulin
/ genetics
Thymus Gland
/ cytology
Transcriptome
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
13
08
2020
accepted:
14
09
2021
entrez:
2
10
2021
pubmed:
3
10
2021
medline:
8
2
2023
Statut:
epublish
Résumé
The thymus is a central lymphoid organ primarily responsible for the development of T cells. A small proportion of B cells, however, also reside in the thymus to assist negative selection of self-reactive T cells. Here we show that the thymus of human neonates contains a consistent contingent of CD138
Identifiants
pubmed: 34599177
doi: 10.1038/s41467-021-26069-2
pii: 10.1038/s41467-021-26069-2
pmc: PMC8486820
doi:
Substances chimiques
Antigens, CD
0
Immunoglobulin G
0
Immunoglobulin Heavy Chains
0
Immunoglobulin Variable Region
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5761Subventions
Organisme : NIAID NIH HHS
ID : U01 AI131339
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100005
Pays : United States
Organisme : NIH HHS
ID : S10 OD020056
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIH HHS
ID : S10 OD016214
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI100005
Pays : United States
Informations de copyright
© 2021. The Author(s).
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